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Determinants of nonhost resistance t...

Huitema, Edgar.

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Determinants of nonhost resistance to Phytophthora infestans.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Determinants of nonhost resistance to Phytophthora infestans./
Author:	Huitema, Edgar.
Description:	256 p.
Notes:	Source: Dissertation Abstracts International, Volume: 66-08, Section: B, page: 4021.
Contained By:	Dissertation Abstracts International66-08B.
Subject:	Agriculture, Plant Pathology. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3182653
ISBN:	9780542236006

Determinants of nonhost resistance to Phytophthora infestans.
Huitema, Edgar.

Determinants of nonhost resistance to Phytophthora infestans. - 256 p.

Source: Dissertation Abstracts International, Volume: 66-08, Section: B, page: 4021.

Thesis (Ph.D.)--The Ohio State University, 2005.

Phytophthora infestans, a plant pathogenic oomycete, causes late blight on potato and tomato resulting in devastating economic losses each year. During infection, P. infestans secretes a diverse set of effector molecules that aim to reprogram the host into a susceptible state. Recognition of effector molecules however, leads to induction of the hypersensitive response (HR) a form of programmed cell death and resistance. Interestingly, both resistant host and nonhost plants display localized HR upon P. infestans ingress, indicating mechanistic similarities or overlap between resistance types. In this dissertation, I investigated the molecular determinants of nonhost resistance and cell death in plants. In order to characterize nonhost resistance, we explored Arabidopsis thaliana-P. infestans associations as a model system. Cytological investigations as well as gene expression analysis revealed that activation of HR and induction of defense responses occurs during P. infestans infection. I investigated the role of P. infestans effector proteins in nonhost resistance and cell death. I showed that INF2A and INF2B induced HR-like cell death in Nicotiana and that INF2A-induced cell death requires the ubiquitin-ligase associated protein SGT1. Consequently, I proposed a role for these genes in avirulence or incompatibility in Nicotiana. I investigated the involvement of cell death in P. infestans-host interactions. I characterized PINPP1.1 and the CRN family and speculated that they represent classes of virulence genes. Comparisons between PINPP1.1, CRN2 and INF1 induced cell death revealed that at least two multiple signaling pathways exist. These differences could reflect functional roles for the CRNs and PINPP1.1 during pathogenesis. Overall I conclude that P. infestans-plant associations are characterized by extensive cellular reprogramming. Characterizations of P. infestans effector genes and understanding the perturbations they facilitate in plants will greatly enhance our understanding of P. infestans virulence and host specificity.

ISBN: 9780542236006Subjects--Topical Terms:

1028950
Agriculture, Plant Pathology.

Determinants of nonhost resistance to Phytophthora infestans.
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100 1 $a Huitema, Edgar. $3 1912009
245 1 0 $a Determinants of nonhost resistance to Phytophthora infestans.
300 $a 256 p.
500 $a Source: Dissertation Abstracts International, Volume: 66-08, Section: B, page: 4021.
500 $a Adviser: Sophien Kamoun.
502 $a Thesis (Ph.D.)--The Ohio State University, 2005.
520 $a Phytophthora infestans, a plant pathogenic oomycete, causes late blight on potato and tomato resulting in devastating economic losses each year. During infection, P. infestans secretes a diverse set of effector molecules that aim to reprogram the host into a susceptible state. Recognition of effector molecules however, leads to induction of the hypersensitive response (HR) a form of programmed cell death and resistance. Interestingly, both resistant host and nonhost plants display localized HR upon P. infestans ingress, indicating mechanistic similarities or overlap between resistance types. In this dissertation, I investigated the molecular determinants of nonhost resistance and cell death in plants. In order to characterize nonhost resistance, we explored Arabidopsis thaliana-P. infestans associations as a model system. Cytological investigations as well as gene expression analysis revealed that activation of HR and induction of defense responses occurs during P. infestans infection. I investigated the role of P. infestans effector proteins in nonhost resistance and cell death. I showed that INF2A and INF2B induced HR-like cell death in Nicotiana and that INF2A-induced cell death requires the ubiquitin-ligase associated protein SGT1. Consequently, I proposed a role for these genes in avirulence or incompatibility in Nicotiana. I investigated the involvement of cell death in P. infestans-host interactions. I characterized PINPP1.1 and the CRN family and speculated that they represent classes of virulence genes. Comparisons between PINPP1.1, CRN2 and INF1 induced cell death revealed that at least two multiple signaling pathways exist. These differences could reflect functional roles for the CRNs and PINPP1.1 during pathogenesis. Overall I conclude that P. infestans-plant associations are characterized by extensive cellular reprogramming. Characterizations of P. infestans effector genes and understanding the perturbations they facilitate in plants will greatly enhance our understanding of P. infestans virulence and host specificity.
590 $a School code: 0168.
650 4 $a Agriculture, Plant Pathology. $3 1028950
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710 2 0 $a The Ohio State University. $3 718944
773 0 $t Dissertation Abstracts International $g 66-08B.
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