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Three-dimensional hyperthermia cance...

Chen, Zong-Ping.

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Three-dimensional hyperthermia cancer treatment simulation.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Three-dimensional hyperthermia cancer treatment simulation./
Author:	Chen, Zong-Ping.
Description:	208 p.
Notes:	Source: Dissertation Abstracts International, Volume: 50-11, Section: B, page: 5191.
Contained By:	Dissertation Abstracts International50-11B.
Subject:	Engineering, Biomedical. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=9010473

Three-dimensional hyperthermia cancer treatment simulation.
Chen, Zong-Ping.

Three-dimensional hyperthermia cancer treatment simulation. - 208 p.

Source: Dissertation Abstracts International, Volume: 50-11, Section: B, page: 5191.

Thesis (Ph.D.)--The University of Arizona, 1989.

A simulation program to study the three dimensional temperature distributions produced by hyperthermia in anatomically realistic inhomogeneous tissue models has been developed. The anatomical data for the inhomogeneous tissues of the human body are entered on a digitizing tablet from serial CT scans. The program not only predicts temperature distributions in regions dominated by blood perfusion (with large number of small capillaries), but it can also predict the temperatures inside of and at the vicinity of large blood vessels. The program can be used for different power deposition patterns from various heating modalities, but they must be calculated independently. In this study, the author's attention has been focused on ferromagnetic implants.Subjects--Topical Terms:

1017684
Engineering, Biomedical.

Three-dimensional hyperthermia cancer treatment simulation.
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035 $a (UnM)AAI9010473
035 $a AAI9010473
040 $a UnM $c UnM
100 1 $a Chen, Zong-Ping. $3 1910717
245 1 0 $a Three-dimensional hyperthermia cancer treatment simulation.
300 $a 208 p.
500 $a Source: Dissertation Abstracts International, Volume: 50-11, Section: B, page: 5191.
500 $a Director: Robert B. Roemer.
502 $a Thesis (Ph.D.)--The University of Arizona, 1989.
520 $a A simulation program to study the three dimensional temperature distributions produced by hyperthermia in anatomically realistic inhomogeneous tissue models has been developed. The anatomical data for the inhomogeneous tissues of the human body are entered on a digitizing tablet from serial CT scans. The program not only predicts temperature distributions in regions dominated by blood perfusion (with large number of small capillaries), but it can also predict the temperatures inside of and at the vicinity of large blood vessels. The program can be used for different power deposition patterns from various heating modalities, but they must be calculated independently. In this study, the author's attention has been focused on ferromagnetic implants.
520 $a The program has been used to comparatively evaluate two and three dimensional simulations in a series of parametric calculations based on simple tissue models for both uniform power deposition and ferromagnetic implants. The conclusions drawn from these studies are that two dimensional simulations can lead to significant errors in many situations, and therefore three dimensional simulations will be necessary for accurate patient treatment planning. The conclusion from the geometrically simple model is substantiated by the results obtained using the full 3D model for actual patient anatomical simulations.
520 $a The program has also been used for several parametric studies. The effect of the thermal conductivity used in the models on the temperature field has been studied, and the results show that its value in the range of 0.4 to 0.6 W/m/ $\ sp\circ
520 $a Finally, the program has been used to analyze a previously performed dog experiment, and a previously performed clinical treatment. A comparison between the predicted temperatures and the measured ones show that good agreement has been achieved for the clinical treatment, but not for the dog experiment. These results are studied in detail, and the conditions under which this program can be used as a hyperthermia patient treatment planning tool is discussed.
590 $a School code: 0009.
650 4 $a Engineering, Biomedical. $3 1017684
650 4 $a Engineering, Mechanical. $3 783786
650 4 $a Health Sciences, Medicine and Surgery. $3 1017756
690 $a 0541
690 $a 0548
690 $a 0564
710 2 0 $a The University of Arizona. $3 1017508
773 0 $t Dissertation Abstracts International $g 50-11B.
790 1 0 $a Roemer, Robert B., $e advisor
790 $a 0009
791 $a Ph.D.
792 $a 1989
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=9010473