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Medical diagnostic microfluidics and...

Minerick, Adrienne Robyn.

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Medical diagnostic microfluidics and physiological blood flow dynamics.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Medical diagnostic microfluidics and physiological blood flow dynamics./
Author:	Minerick, Adrienne Robyn.
Description:	141 p.
Notes:	Source: Dissertation Abstracts International, Volume: 64-05, Section: B, page: 2285.
Contained By:	Dissertation Abstracts International64-05B.
Subject:	Engineering, Biomedical. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3090292
ISBN:	9780496380176

Medical diagnostic microfluidics and physiological blood flow dynamics.
Minerick, Adrienne Robyn.

Medical diagnostic microfluidics and physiological blood flow dynamics. - 141 p.

Source: Dissertation Abstracts International, Volume: 64-05, Section: B, page: 2285.

Thesis (Ph.D.)--University of Notre Dame, 2003.

The earliest work described uses time series analysis of a live trout cardiovascular system to examine the relationship between venous pressure and cardiac output. This led to experimental work on red blood cell (RBC) DC electrokinetic transport in a capillary system and uncovered ionic limitations inherent in the small volumes of fluid used in microdevices. Further exploration of RBC characteristics revealed a unique polarization phenomena existing in a non-uniform AC field microdevice.

ISBN: 9780496380176Subjects--Topical Terms:

1017684
Engineering, Biomedical.

Medical diagnostic microfluidics and physiological blood flow dynamics.
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020 $a 9780496380176
035 $a (UnM)AAI3090292
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100 1 $a Minerick, Adrienne Robyn. $3 1910107
245 1 0 $a Medical diagnostic microfluidics and physiological blood flow dynamics.
300 $a 141 p.
500 $a Source: Dissertation Abstracts International, Volume: 64-05, Section: B, page: 2285.
500 $a Director: Hsueh-Chia Chang.
502 $a Thesis (Ph.D.)--University of Notre Dame, 2003.
520 $a The earliest work described uses time series analysis of a live trout cardiovascular system to examine the relationship between venous pressure and cardiac output. This led to experimental work on red blood cell (RBC) DC electrokinetic transport in a capillary system and uncovered ionic limitations inherent in the small volumes of fluid used in microdevices. Further exploration of RBC characteristics revealed a unique polarization phenomena existing in a non-uniform AC field microdevice.
520 $a The interactions between venous pressure and cardiac output were examined by periodically infusing and withdrawing blood into a live trout's cardiovascular system. Time series analysis and the Hilbert transform were used to extract from raw frequency response data information that reveals that (a) cardiac output is determined by venous pressures behind the heart and (b) heart rate and stroke volume adapt through regulatory mechanisms to make minor adjustments to cardiac output. This could potentially impact our understanding of hypertension, a disease characterized by high blood pressures.
520 $a In the second phase of this research, red blood cell movement in capillaries was examined using video microscopy. Flow direction anomalies were observed experimentally and explained by the development of a pH gradient between the cathode well and the anode well due to electrode electrolysis reactions. The development of the pH gradient inside the 20 micron capillary was also imaged with a fluorescent pH indicator, Rhodol Green(TM) carboxylic acid.
520 $a A new electrokinetic technique known as dielectrophoresis (AC, non-uniform field) was utilized to further probe red blood cell characteristics. This work revealed an unexplored repulsion mechanism due to polarization of the red blood cell's Debye layer interacting with the electrode's polarized Debye layer. Cell-cell interactions also play a key role in suspension behaviors within the dielectrophoretic microdevice.
520 $a DC and AC electrokinetic research of red blood cells may lead to the development of medical diagnostic kits capable of (a) screening for a person's blood/drug compatibility before systemic administration of the medication, (b) screening blood for toxin exposure, or (c) cellular separations. Collectively, this work has explored macro and microscopic characteristics of blood ranging from the entire cardiovascular system to cellular interactions with electrically influenced surfaces.
590 $a School code: 0165.
650 4 $a Engineering, Biomedical. $3 1017684
650 4 $a Engineering, Chemical. $3 1018531
650 4 $a Biology, Animal Physiology. $3 1017835
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710 2 0 $a University of Notre Dame. $3 807615
773 0 $t Dissertation Abstracts International $g 64-05B.
790 1 0 $a Chang, Hsueh-Chia, $e advisor
790 $a 0165
791 $a Ph.D.
792 $a 2003
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3090292