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Viscoelastic gels resistant to mucoc...

Shah, Ankur Janak.

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Viscoelastic gels resistant to mucociliary clearance: Rheological and chemical optimization for prolonged mucosal contact.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Viscoelastic gels resistant to mucociliary clearance: Rheological and chemical optimization for prolonged mucosal contact./
Author:	Shah, Ankur Janak.
Description:	138 p.
Notes:	Source: Dissertation Abstracts International, Volume: 66-08, Section: B, page: 4176.
Contained By:	Dissertation Abstracts International66-08B.
Subject:	Health Sciences, Pharmacy. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3184754
ISBN:	9780542263637

Viscoelastic gels resistant to mucociliary clearance: Rheological and chemical optimization for prolonged mucosal contact.
Shah, Ankur Janak.

Viscoelastic gels resistant to mucociliary clearance: Rheological and chemical optimization for prolonged mucosal contact. - 138 p.

Source: Dissertation Abstracts International, Volume: 66-08, Section: B, page: 4176.

Thesis (Ph.D.)--The University of Iowa, 2005.

Mucociliary clearance reduces intranasal residence time and significantly limits the time available for the absorption of drugs. The inclusion of bioadhesive polymers in nasal drug formulations can increase the residence time by altering the normal rheological properties of mucus resulting in a reduction in the mucociliary transit rate (MTR).

ISBN: 9780542263637Subjects--Topical Terms:

1017737
Health Sciences, Pharmacy.

Viscoelastic gels resistant to mucociliary clearance: Rheological and chemical optimization for prolonged mucosal contact.
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100 1 $a Shah, Ankur Janak. $3 1910040
245 1 0 $a Viscoelastic gels resistant to mucociliary clearance: Rheological and chemical optimization for prolonged mucosal contact.
300 $a 138 p.
500 $a Source: Dissertation Abstracts International, Volume: 66-08, Section: B, page: 4176.
500 $a Supervisor: Maureen D. Donovan.
502 $a Thesis (Ph.D.)--The University of Iowa, 2005.
520 $a Mucociliary clearance reduces intranasal residence time and significantly limits the time available for the absorption of drugs. The inclusion of bioadhesive polymers in nasal drug formulations can increase the residence time by altering the normal rheological properties of mucus resulting in a reduction in the mucociliary transit rate (MTR).
520 $a The clearance characteristics of bioadhesive polysaccharide and polyacrylic acid gels were assessed in vitro by measuring their transport rates across explants of ciliated bovine tracheal tissue. The viscoelastic properties of these polymer systems were measured using controlled stress rheometry in the presence of physiologically relevant concentrations of mucus at an oscillatory frequency of 3.16 Hz. Polymer class-specific thresholds, beyond which further increases in concentration did not yield any further reductions in MTR, were identified for each of the rheologic parameters. Combinations of apparent viscosity (eta) and complex modulus (G*) were found to be the most useful parameters in the identification of formulations capable of decreasing MTR and increasing intranasal residence time.
520 $a The release rate of a test compound, 6-carboxyfluorescein (6-CF), from the polysaccharide gels was measured to determine the extent of reduction in drug release with increasing viscosity. Polymer gels with >80% MTR reduction were shown to have slower 6-CF release rates than those with <40% MTR reductions.
520 $a To test whether decreases in in vitro MTR correlated with improved bioavailabilities, an in vivo rat model was used, and 6-CF was included as the model drug in each of the formulations investigated. Polymers with <40% and >80% reductions in MTR were either unable to retain a sufficient amount of formulation in the nasal cavity or posed significant administration problems. Those with 50% to 75% reductions in MTR showed a good compromise between increased intranasal residence time and adequate drug release, together which resulted in improved systemic bioavailabilities of 6-CF.
520 $a These studies demonstrated that there is a narrow range of viscoelastic characteristics unique to each polymer class that result in gels with reduced mucociliary clearance and sufficient drug release to result in increased bioavailability following intranasal administration.
590 $a School code: 0096.
650 4 $a Health Sciences, Pharmacy. $3 1017737
690 $a 0572
710 2 0 $a The University of Iowa. $3 1017439
773 0 $t Dissertation Abstracts International $g 66-08B.
790 1 0 $a Donovan, Maureen D., $e advisor
790 $a 0096
791 $a Ph.D.
792 $a 2005
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3184754