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Methodological review and meta-analy...

Guggisberg, Kristin Wilson.

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Methodological review and meta-analysis of treatments for child and adolescent obsessive-compulsive disorder.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Methodological review and meta-analysis of treatments for child and adolescent obsessive-compulsive disorder./
Author:	Guggisberg, Kristin Wilson.
Description:	236 p.
Notes:	Source: Dissertation Abstracts International, Volume: 66-02, Section: B, page: 1170.
Contained By:	Dissertation Abstracts International66-02B.
Subject:	Psychology, Clinical. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3166033
ISBN:	0542014734

Methodological review and meta-analysis of treatments for child and adolescent obsessive-compulsive disorder.
Guggisberg, Kristin Wilson.

Methodological review and meta-analysis of treatments for child and adolescent obsessive-compulsive disorder. - 236 p.

Source: Dissertation Abstracts International, Volume: 66-02, Section: B, page: 1170.

Thesis (Ph.D.)--The University of Utah, 2005.

The purpose of this investigation was twofold: (a) to critically review the quality of the methodology employed in published studies of child and adolescent treatments for obsessive-compulsive disorder (OCD) and (b) to conduct a meta analysis of published and unpublished studies of pharmacological and behavioral treatments for pediatric OCD.

ISBN: 0542014734Subjects--Topical Terms:

524864
Psychology, Clinical.

Methodological review and meta-analysis of treatments for child and adolescent obsessive-compulsive disorder.
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100 1 $a Guggisberg, Kristin Wilson. $3 1908596
245 1 0 $a Methodological review and meta-analysis of treatments for child and adolescent obsessive-compulsive disorder.
300 $a 236 p.
500 $a Source: Dissertation Abstracts International, Volume: 66-02, Section: B, page: 1170.
500 $a Adviser: Elaine Clark.
502 $a Thesis (Ph.D.)--The University of Utah, 2005.
520 $a The purpose of this investigation was twofold: (a) to critically review the quality of the methodology employed in published studies of child and adolescent treatments for obsessive-compulsive disorder (OCD) and (b) to conduct a meta analysis of published and unpublished studies of pharmacological and behavioral treatments for pediatric OCD.
520 $a For the methodological review, an exhaustive literature search yielded 93 published studies of various study designs. The threats-to-validity framework was applied, with the results indicating that the treatment literature attended acceptably to some threats but insufficiently to several others. Specifically, power was adequate to detect a large treatment effect, and reliable instruments were used in half the studies. Internal validity was perhaps the most problematic; that is, only 14% of the studies used a study design employing a control group with random assignment. With regard to construct validity, most studies failed to use multimodal assessment and relied primarily on indirect forms of measurement. Demand characteristics were free to influence results in most studies, since placebo control was used in only 12% of the studies. Finally, external validity suffered from the failure to report basic subject or clinician demographics. Prescriptive suggestions for improving treatment research are offered.
520 $a Thirty-two studies, including controlled and uncontrolled trials, were included in the meta-analysis to determine the efficacy of both pharmacological and behavioral treatments. Pharmacological treatments included clomipramine, citalopram, fluoxetine, fluvoxamine, paroxetine, and sertraline. Behavioral treatments consisted of variants of cognitive-behavioral therapy (CBT) with exposure-and-response prevention (ERP). The literature was also gleaned for single-subject studies that met sufficient inclusion criteria. However, only 5 studies were found, and these were not analyzed by meta-analysis.
520 $a Hierarchical linear modeling (HLM) revealed a significant, standardized mean effect size of 1.32. The study design variable, whether a study used a control group, accounted for 77% of the reliable variance. Study design was used as a covariate. Thus, none of the other moderator variables, including type of intervention (pharmacological versus behavioral), accounted for any significant variance. Well-designed, head-to-head comparative studies are needed to compare the relative efficacy of treatments. Implications for future research and the limitations of the current study are delineated.
590 $a School code: 0240.
650 4 $a Psychology, Clinical. $3 524864
650 4 $a Health Sciences, Mental Health. $3 1017693
690 $a 0622
690 $a 0347
710 2 0 $a The University of Utah. $3 1017410
773 0 $t Dissertation Abstracts International $g 66-02B.
790 1 0 $a Clark, Elaine, $e advisor
790 $a 0240
791 $a Ph.D.
792 $a 2005
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3166033