東華大學圖書館 |

Language: English

Help

回圖書館首頁

手機版館藏查詢

Back

Switch To: Labeled | MARC Mode | ISBD

The role of cyclopentenone isoprosta...

Musiek, Erik Steven.

Linked to FindBook

Google Book

Amazon

博客來

The role of cyclopentenone isoprostanes in neurodegeneration and inflammation.

Record Type:	Electronic resources : Monograph/item
Title/Author:	The role of cyclopentenone isoprostanes in neurodegeneration and inflammation./
Author:	Musiek, Erik Steven.
Description:	143 p.
Notes:	Source: Dissertation Abstracts International, Volume: 66-04, Section: B, page: 1920.
Contained By:	Dissertation Abstracts International66-04B.
Subject:	Biology, Neuroscience. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3170649
ISBN:	0542071916

The role of cyclopentenone isoprostanes in neurodegeneration and inflammation.
Musiek, Erik Steven.

The role of cyclopentenone isoprostanes in neurodegeneration and inflammation. - 143 p.

Source: Dissertation Abstracts International, Volume: 66-04, Section: B, page: 1920.

Thesis (Ph.D.)--Vanderbilt University, 2005.

This dissertation examines the biological actions of cyclopentenone (A 2/J2) isoprostanes, reactive lipid peroxidation products formed in vivo under conditions of oxidative stress. Mass spectrometric evidence is presented demonstrating that cyclopentenone isoprostanes are formed abundantly in rodent and human brain tissue, and are increased under condition of oxidant injury. Experiments employing synthetic cyclopentenone isoprostanes (15-A2- and 15-J2-IsoPs) reveal that these compounds are highly neurotoxic, and induce neuronal apoptosis at biologically relevant concentrations via activation of discreet, redox-sensitive signaling pathways. Cyclopentenone IsoPs also potentiate neuronal death in several models of neurodegeneration. Further data is included showing that these compounds can also modulate the inflammatory response via inhibition of the NF-kappaB pathway in macrophages. This dissertation provides evidence that cyclopentenone isoprostanes are highly bioactive lipid peroxidation products, and may mediate some of the pathogenic effects of oxidative stress.

ISBN: 0542071916Subjects--Topical Terms:

1017680
Biology, Neuroscience.

The role of cyclopentenone isoprostanes in neurodegeneration and inflammation.
LDR:02010nmm 2200301 4500 001 1819188
005 20061004161524.5
008 130610s2005 eng d
020 $a 0542071916
035 $a (UnM)AAI3170649
035 $a AAI3170649
040 $a UnM $c UnM
100 1 $a Musiek, Erik Steven. $3 1908485
245 1 4 $a The role of cyclopentenone isoprostanes in neurodegeneration and inflammation.
300 $a 143 p.
500 $a Source: Dissertation Abstracts International, Volume: 66-04, Section: B, page: 1920.
500 $a Director: Jason D. Morrow.
502 $a Thesis (Ph.D.)--Vanderbilt University, 2005.
520 $a This dissertation examines the biological actions of cyclopentenone (A 2/J2) isoprostanes, reactive lipid peroxidation products formed in vivo under conditions of oxidative stress. Mass spectrometric evidence is presented demonstrating that cyclopentenone isoprostanes are formed abundantly in rodent and human brain tissue, and are increased under condition of oxidant injury. Experiments employing synthetic cyclopentenone isoprostanes (15-A2- and 15-J2-IsoPs) reveal that these compounds are highly neurotoxic, and induce neuronal apoptosis at biologically relevant concentrations via activation of discreet, redox-sensitive signaling pathways. Cyclopentenone IsoPs also potentiate neuronal death in several models of neurodegeneration. Further data is included showing that these compounds can also modulate the inflammatory response via inhibition of the NF-kappaB pathway in macrophages. This dissertation provides evidence that cyclopentenone isoprostanes are highly bioactive lipid peroxidation products, and may mediate some of the pathogenic effects of oxidative stress.
590 $a School code: 0242.
650 4 $a Biology, Neuroscience. $3 1017680
650 4 $a Biology, Cell. $3 1017686
650 4 $a Chemistry, Biochemistry. $3 1017722
650 4 $a Health Sciences, Pharmacology. $3 1017717
690 $a 0317
690 $a 0379
690 $a 0487
690 $a 0419
710 2 0 $a Vanderbilt University. $3 1017501
773 0 $t Dissertation Abstracts International $g 66-04B.
790 1 0 $a Morrow, Jason D., $e advisor
790 $a 0242
791 $a Ph.D.
792 $a 2005
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3170649