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Antibacterial effect of HVPC in vivo...

Campolo, Marc.

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Antibacterial effect of HVPC in vivo (Electrical stimulation, Wound healing).

Record Type:	Electronic resources : Monograph/item
Title/Author:	Antibacterial effect of HVPC in vivo (Electrical stimulation, Wound healing)./
Author:	Campolo, Marc.
Description:	56 p.
Notes:	Source: Dissertation Abstracts International, Volume: 61-04, Section: B, page: 1916.
Contained By:	Dissertation Abstracts International61-04B.
Subject:	Health Sciences, Rehabilitation and Therapy. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=9969970
ISBN:	0599749091

Antibacterial effect of HVPC in vivo (Electrical stimulation, Wound healing).
Campolo, Marc.

Antibacterial effect of HVPC in vivo (Electrical stimulation, Wound healing). - 56 p.

Source: Dissertation Abstracts International, Volume: 61-04, Section: B, page: 1916.

Thesis (Ph.D.)--Seton Hall University, College of Education and Human Services, 1999.

A historical review of the literature reveals that low intensity direct current (LIDC) is effective in the treatment of infected wounds. Since the 1970's, high voltage pulsed current (HVPC) stimulators have been used for the same purpose based on the assumption that they have the same physiological effects as LIDC. To date; however, there is insufficient research to support clinical use of HVPC for infected wounds. The purposed of this pilot study was to determine whether HVPC has an inhibitory effect on bacteria in vivo in order to provide evidence to support the clinical use of HVPC stimulation in the treatment of infected wounds. The subjects consisted of 12 New Zealand rabbits of equivalent size, weight and age.

ISBN: 0599749091Subjects--Topical Terms:

1017926
Health Sciences, Rehabilitation and Therapy.

Antibacterial effect of HVPC in vivo (Electrical stimulation, Wound healing).
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100 1 $a Campolo, Marc. $3 1907489
245 1 0 $a Antibacterial effect of HVPC in vivo (Electrical stimulation, Wound healing).
300 $a 56 p.
500 $a Source: Dissertation Abstracts International, Volume: 61-04, Section: B, page: 1916.
500 $a Adviser: Genevieve Pinto-Zipp.
502 $a Thesis (Ph.D.)--Seton Hall University, College of Education and Human Services, 1999.
520 $a A historical review of the literature reveals that low intensity direct current (LIDC) is effective in the treatment of infected wounds. Since the 1970's, high voltage pulsed current (HVPC) stimulators have been used for the same purpose based on the assumption that they have the same physiological effects as LIDC. To date; however, there is insufficient research to support clinical use of HVPC for infected wounds. The purposed of this pilot study was to determine whether HVPC has an inhibitory effect on bacteria in vivo in order to provide evidence to support the clinical use of HVPC stimulation in the treatment of infected wounds. The subjects consisted of 12 New Zealand rabbits of equivalent size, weight and age.
520 $a The animals were randomly assigned to either an experimental group (EXP = 7) or a control group (CON = 8). Each animal was anesthetized and a full thickness wound (2cm by 3cm) was made on their backs, which was then infected with 1 M. of 1 x 107 Staphylococcus aureus solution. The wound was then covered with a sterile dressing. Bacterial colony counts, measured in CFU's, were used to establish both the initial and final level of infection. The parameters chosen were consistent with those recommended clinically: the waveform was monophasic and twin peak in shape, the phase duration was 75 usec, the pulse rate was 7100 pps, the amplitude was the highest obtainable without causing muscular contraction (not to exceed 100V), and the current modulations was continuous.
520 $a A Mann-Whitney U test (Table 3) conducted compared the difference between the % change of the bacterial counts, revealed that there was no statistically significant difference between the EXP and CON groups from the initial to final condition. Although statistical significance was not achieved, further assessment of the data revealed to interesting trends. First, it was noted that the EXP group consistently exhibited a substantial decrease in their bacterial counts across all subjects and almost complete abolition in most subjects. Second, the mean rank of the CON group increased from 6.69 to 8.75, while that of the EXP group decreased from 9.50 to 7.14.
520 $a Although statistical significance may not have been achieved, based upon the noted trends in the data, the author suggests that HVPC may have contributed to the demonstrated positive trends of exhibiting bactericidal effects in acute wounds of animals. Further studies using human subjects are necessary to truly establish the efficacy of the antibacterial effects of HVPC. (Abstract shortened by UMI.)
590 $a School code: 1241.
650 4 $a Health Sciences, Rehabilitation and Therapy. $3 1017926
650 4 $a Engineering, Biomedical. $3 1017684
650 4 $a Health Sciences, Medicine and Surgery. $3 1017756
690 $a 0382
690 $a 0541
690 $a 0564
710 2 0 $a Seton Hall University, College of Education and Human Services. $3 576299
773 0 $t Dissertation Abstracts International $g 61-04B.
790 1 0 $a Pinto-Zipp, Genevieve, $e advisor
790 $a 1241
791 $a Ph.D.
792 $a 1999
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=9969970