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Expression of neuronal proteins in a...

Chen, Ya.

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Expression of neuronal proteins in a differentiating human neuroblastoma cell line (IMR32): Insights into neuronal development and disease.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Expression of neuronal proteins in a differentiating human neuroblastoma cell line (IMR32): Insights into neuronal development and disease./
Author:	Chen, Ya.
Description:	199 p.
Notes:	Source: Dissertation Abstracts International, Volume: 66-10, Section: B, page: 5251.
Contained By:	Dissertation Abstracts International66-10B.
Subject:	Biology, Neuroscience. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3193556
ISBN:	0542369877

Expression of neuronal proteins in a differentiating human neuroblastoma cell line (IMR32): Insights into neuronal development and disease.
Chen, Ya.

Expression of neuronal proteins in a differentiating human neuroblastoma cell line (IMR32): Insights into neuronal development and disease. - 199 p.

Source: Dissertation Abstracts International, Volume: 66-10, Section: B, page: 5251.

Thesis (Ph.D.)--Case Western Reserve University, 2006.

The acquisition of a neuronal phenotype by exposure to specific intrinsic and extrinsic signals is a property of neuroblasts, adult neural stem cells, and the IMR32 human neuroblastoma cell line. As several complex psychiatric, cognitive, and neurological human disorders such as schizophrenia, autism, and some epilepsies are now being approached as neurodevelopmental disorders, it is critical to understand the normal course of neuronal differentiation with the long term goal of strategic intervention and management of the chronic and debilitating diseases. In my thesis, we explore the use of IMR32 cells as a simplified and accessible model system for studying neuronal differentiation and exploring the expression of proteins with synaptic functions; specifically, secretory proteins, voltage-dependent calcium channels, and proteins implicated in growth cone formation and neurite formation. We also explore the expression of MeCP2 and use a novel antibody to neural cell adhesion molecule (NCAM) 180 kDa isoform to monitor the acquisition of a neuronal phenotype in parallel to other markers of synaptic function. The biochemical analyses of VDCC assembly in IMR32 cells and expression of VDCC subunits have identified how alpha 1 and beta subunits are assembled in a single cell type. Thus, the use of differentiated IMR32 cells as a cell model offers a unique cell population for future study on neuronal differentiation and neuronal proteins involved with neurodevelopmental disorders in vitro.

ISBN: 0542369877Subjects--Topical Terms:

1017680
Biology, Neuroscience.

Expression of neuronal proteins in a differentiating human neuroblastoma cell line (IMR32): Insights into neuronal development and disease.
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100 1 $a Chen, Ya. $3 1907261
245 1 0 $a Expression of neuronal proteins in a differentiating human neuroblastoma cell line (IMR32): Insights into neuronal development and disease.
300 $a 199 p.
500 $a Source: Dissertation Abstracts International, Volume: 66-10, Section: B, page: 5251.
500 $a Advisers: Maureen W. McEnery; Rolfe G. Petschek.
502 $a Thesis (Ph.D.)--Case Western Reserve University, 2006.
520 $a The acquisition of a neuronal phenotype by exposure to specific intrinsic and extrinsic signals is a property of neuroblasts, adult neural stem cells, and the IMR32 human neuroblastoma cell line. As several complex psychiatric, cognitive, and neurological human disorders such as schizophrenia, autism, and some epilepsies are now being approached as neurodevelopmental disorders, it is critical to understand the normal course of neuronal differentiation with the long term goal of strategic intervention and management of the chronic and debilitating diseases. In my thesis, we explore the use of IMR32 cells as a simplified and accessible model system for studying neuronal differentiation and exploring the expression of proteins with synaptic functions; specifically, secretory proteins, voltage-dependent calcium channels, and proteins implicated in growth cone formation and neurite formation. We also explore the expression of MeCP2 and use a novel antibody to neural cell adhesion molecule (NCAM) 180 kDa isoform to monitor the acquisition of a neuronal phenotype in parallel to other markers of synaptic function. The biochemical analyses of VDCC assembly in IMR32 cells and expression of VDCC subunits have identified how alpha 1 and beta subunits are assembled in a single cell type. Thus, the use of differentiated IMR32 cells as a cell model offers a unique cell population for future study on neuronal differentiation and neuronal proteins involved with neurodevelopmental disorders in vitro.
590 $a School code: 0042.
650 4 $a Biology, Neuroscience. $3 1017680
650 4 $a Health Sciences, Pathology. $3 1017854
690 $a 0317
690 $a 0571
710 2 0 $a Case Western Reserve University. $3 1017714
773 0 $t Dissertation Abstracts International $g 66-10B.
790 1 0 $a McEnery, Maureen W., $e advisor
790 1 0 $a Petschek, Rolfe G., $e advisor
790 $a 0042
791 $a Ph.D.
792 $a 2006
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3193556