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Mechanisms of respiratory rhythmogen...

Vasilakos, Konstantinon.

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Mechanisms of respiratory rhythmogenesis: Chloride-mediated and opioid-sensitive elements.

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Mechanisms of respiratory rhythmogenesis: Chloride-mediated and opioid-sensitive elements./
作者:	Vasilakos, Konstantinon.
面頁冊數:	267 p.
附註:	Source: Dissertation Abstracts International, Volume: 66-07, Section: B, page: 3498.
Contained By:	Dissertation Abstracts International66-07B.
標題:	Biology, Animal Physiology. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=NR04623
ISBN:	0494046236

Mechanisms of respiratory rhythmogenesis: Chloride-mediated and opioid-sensitive elements.
Vasilakos, Konstantinon.

Mechanisms of respiratory rhythmogenesis: Chloride-mediated and opioid-sensitive elements. - 267 p.

Source: Dissertation Abstracts International, Volume: 66-07, Section: B, page: 3498.

Thesis (Ph.D.)--University of Calgary (Canada), 2005.

The mechanisms by which the brain generates the respiratory rhythm are not understood. The architecture of the brainstem respiratory central pattern generator (CPG) is a matter of debate. Controversies persist on the roles played by "pacemaker" neurons, i.e. endogenously rhythmic neurons, and "network elements", i.e. neuronal circuitry whose rhythm emerges as a consequence of the synaptic connections within the network, in respiratory rhythmogenesis. The debate has matured to a point where hybrid proposals, incorporating both pacemaker and network properties, are now being put forth.

ISBN: 0494046236Subjects--Topical Terms:

1017835
Biology, Animal Physiology.

Mechanisms of respiratory rhythmogenesis: Chloride-mediated and opioid-sensitive elements.
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245 1 0 $a Mechanisms of respiratory rhythmogenesis: Chloride-mediated and opioid-sensitive elements.
300 $a 267 p.
500 $a Source: Dissertation Abstracts International, Volume: 66-07, Section: B, page: 3498.
502 $a Thesis (Ph.D.)--University of Calgary (Canada), 2005.
520 $a The mechanisms by which the brain generates the respiratory rhythm are not understood. The architecture of the brainstem respiratory central pattern generator (CPG) is a matter of debate. Controversies persist on the roles played by "pacemaker" neurons, i.e. endogenously rhythmic neurons, and "network elements", i.e. neuronal circuitry whose rhythm emerges as a consequence of the synaptic connections within the network, in respiratory rhythmogenesis. The debate has matured to a point where hybrid proposals, incorporating both pacemaker and network properties, are now being put forth.
520 $a Recent studies have proposed that a bilateral pair of coupled oscillators forms the basis of the CPG in both frogs and rats. This thesis investigates the hypothesis that the respiratory bursts in the frog are heterogenous, with elements of the burst being produced by different oscillators. To test the hypothesis, the putative frog oscillators, namely the lung and buccal oscillators, were probed with interventions which preferentially suppressed either the hung or buccal rhythm. Suppression of one the rhythms is taken as evidence of the suppression of the eponymous oscillator.
520 $a I used a reduced chloride superfusate to preferentially disrupt the buccal rhythm and oscillator. This disruption also suppressed the first phase of the biphasic lung burst. I then demonstrated that the mu-opioid agonist DAMGO preferentially suppresses the lung rhythm and oscillator. The opioid, in addition to slowing both oscillators, reduces the probability of lung bursts to occur. By alternately suppressing and driving the lung oscillator, I provide evidence that the buccal oscillator is setting the pace in the system.
520 $a I jointly apply both interventions to the in vitro preparation and partially uncouple the buccal and lung rhythms. Specifically; in a reduced Cl- + DAMGO superfusate, the buccal rhythm is no longer coupled to the lung rhythm but the lung rhythm remains coupled to the buccal rhythm. I repeat these results using hypocapnia in the place of DAMGO to suggest that the suppression of the lung oscillator is important in the manifestation of this phenomenon.
520 $a From these studies I conclude that two distinct oscillators exist in the frog brainstem. From the Cl- reduction effects, I argue that the biphasic lung burst in the frog is generated by both oscillators, with the buccal oscillator generating the first phase of the heterogenous lung burst and the lung oscillator generating the second phase.
590 $a School code: 0026.
650 4 $a Biology, Animal Physiology. $3 1017835
650 4 $a Biology, Neuroscience. $3 1017680
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710 2 0 $a University of Calgary (Canada). $3 1017619
773 0 $t Dissertation Abstracts International $g 66-07B.
790 $a 0026
791 $a Ph.D.
792 $a 2005
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