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The Drosophila and Manduca hearts as...

Dulcis, Davide.

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The Drosophila and Manduca hearts as models for studying the role of innervation in cardiac function.

Record Type:	Electronic resources : Monograph/item
Title/Author:	The Drosophila and Manduca hearts as models for studying the role of innervation in cardiac function./
Author:	Dulcis, Davide.
Description:	202 p.
Notes:	Source: Dissertation Abstracts International, Volume: 65-09, Section: B, page: 4436.
Contained By:	Dissertation Abstracts International65-09B.
Subject:	Biology, Neuroscience. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3145063
ISBN:	049603622X

The Drosophila and Manduca hearts as models for studying the role of innervation in cardiac function.
Dulcis, Davide.

The Drosophila and Manduca hearts as models for studying the role of innervation in cardiac function. - 202 p.

Source: Dissertation Abstracts International, Volume: 65-09, Section: B, page: 4436.

Thesis (Ph.D.)--The University of Arizona, 2004.

Cardiac activity of Drosophila melanogaster and Manduca sexta changes during metamorphosis. The larval heart has only anterograde contractions. Adult heart activity becomes a cyclic alternation of anterograde and retrograde contractions originated by putative anterograde and retrograde pacemakers.

ISBN: 049603622XSubjects--Topical Terms:

1017680
Biology, Neuroscience.

The Drosophila and Manduca hearts as models for studying the role of innervation in cardiac function.
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100 1 $a Dulcis, Davide. $3 1907240
245 1 4 $a The Drosophila and Manduca hearts as models for studying the role of innervation in cardiac function.
300 $a 202 p.
500 $a Source: Dissertation Abstracts International, Volume: 65-09, Section: B, page: 4436.
500 $a Director: Richard B. Levine.
502 $a Thesis (Ph.D.)--The University of Arizona, 2004.
520 $a Cardiac activity of Drosophila melanogaster and Manduca sexta changes during metamorphosis. The larval heart has only anterograde contractions. Adult heart activity becomes a cyclic alternation of anterograde and retrograde contractions originated by putative anterograde and retrograde pacemakers.
520 $a During development, the larval skeletal muscle motoneuron-1 in abdominal segments 7 and 8 becomes respecified to innervate the terminal cardiac chamber of adult Manduca and undergoes morphological and physiological reorganization. MNs-1 activate and sustain the anterograde pacemaker activity of the terminal chamber.
520 $a The innervation of the adult abdominal heart of Drosophila melanogaster was studied to determine whether the adult heart receives neuronal input or whether its complex activity must be considered independent from the nervous system. The larval heart lacks innervation suggesting a myogenic cardiac impulse. At metamorphosis, neural processes grow onto the myocardium. A pair of glutamatergic transverse nerves innervates bilaterally each cardiac chamber. In addition, CCAP-immunoreactive fibers originating from peripheral, bipolar neurons (BpNs) fasciculate with the transverse nerve projections and terminate segmentally throughout the abdominal heart.
520 $a To determine the role of this innervation in cardiac function, a novel optical technique based on the movement of GFP-labeled nerve terminals was developed to monitor heartbeat in intact preparations. Simultaneous monitoring of adjacent cardiac chambers revealed the direction of contractions and allowed correlation with volume changes. Intracellular recordings from the first abdominal cardiac chamber, the conical chamber, revealed pacemaker action potentials and the excitatory effect of local glutamate application. Bath-applied glutamate initiated retrograde contractions in semi-intact preparations. Similarly, electrical stimulation of the transverse nerve that serves the conical chamber caused a chronotropic effect and initiation of retrograde contractions. This effect is distinct from that of peripheral CCAP-immunoreactive neurons, which potentiate the anterograde beat. Cardiac reversal was evoked pharmacologically by sequentially applying CCAP and glutamate to the heart.
520 $a The role of the neuropeptide, Crustacean Cardioactive Peptide (CCAP) in adult Drosophila melanogaster cardiac function was studied by RNA interference (RNAi) and targeted cell ablation. CCAP has a cardioacceleratory effect when it is applied in vitro. Lack of CCAP-innervation in CCAP knock-out flies altered one cardiac phase, the anterograde beat, without preventing the cyclic cardiac reversal.
590 $a School code: 0009.
650 4 $a Biology, Neuroscience. $3 1017680
650 4 $a Biology, Anatomy. $3 1021727
690 $a 0317
690 $a 0287
710 2 0 $a The University of Arizona. $3 1017508
773 0 $t Dissertation Abstracts International $g 65-09B.
790 1 0 $a Levine, Richard B., $e advisor
790 $a 0009
791 $a Ph.D.
792 $a 2004
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3145063