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Implications of cotransmission and n...

Thirumalai, Vatsala.

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Implications of cotransmission and neuromodulation for neural network function.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Implications of cotransmission and neuromodulation for neural network function./
Author:	Thirumalai, Vatsala.
Description:	156 p.
Notes:	Source: Dissertation Abstracts International, Volume: 63-03, Section: B, page: 1203.
Contained By:	Dissertation Abstracts International63-03B.
Subject:	Biology, Neuroscience. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3045912
ISBN:	049359907X

Implications of cotransmission and neuromodulation for neural network function.
Thirumalai, Vatsala.

Implications of cotransmission and neuromodulation for neural network function. - 156 p.

Source: Dissertation Abstracts International, Volume: 63-03, Section: B, page: 1203.

Thesis (Ph.D.)--Brandeis University, 2002.

Neuromodulators act on neural circuits to alter the properties of constituent neurons. This study is an attempt to understand how such individual changes at the cellular level translate into change at the network level.

ISBN: 049359907XSubjects--Topical Terms:

1017680
Biology, Neuroscience.

Implications of cotransmission and neuromodulation for neural network function.
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020 $a 049359907X
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100 1 $a Thirumalai, Vatsala. $3 1907211
245 1 0 $a Implications of cotransmission and neuromodulation for neural network function.
300 $a 156 p.
500 $a Source: Dissertation Abstracts International, Volume: 63-03, Section: B, page: 1203.
500 $a Adviser: Eve Marder.
502 $a Thesis (Ph.D.)--Brandeis University, 2002.
520 $a Neuromodulators act on neural circuits to alter the properties of constituent neurons. This study is an attempt to understand how such individual changes at the cellular level translate into change at the network level.
520 $a When the stomatogastric ganglion (STG) was isolated from inputs from anterior ganglia, the pyloric rhythm consisting of the repeated firings of the Pyloric Dilator (PD), Lateral Pyloric (LP), and the Pyloric (PY) neurons stopped. The PD and the Anterior Burster (AB) neurons continued to burst at a lower frequency. Phase response curves (PRCs) were used to establish that the pyloric oscillators in the STG do not receive obligatory timing cues from anterior ganglia.
520 $a Red pigment concentrating hormone (RPCH) and Cancer borealis tachykinin related peptide (CabTRP) are colocalized within the neurophil of the STG. RPCH activated the LP and PD neurons while CabTRP activated the PD and PY neurons. When RPCH and CabTRP were bath applied together, the PD, LP and PY neurons were activated and a full triphasic, pyloric rhythm resulted.
520 $a The LP to PD synapse is the only feedback synapse from within the pyloric circuit to the pacemaker group. RPCH increased the strength of the LP to PD synapse by several fold. Yet, in RPCH, there was only a modest decrease in pyloric cycle frequency. The LP neuron was removed from the circuit and artificial synaptic conductances were injected into the PD neuron to study its response to inputs of different strengths. The PRC of the PD neuron was not altered even if the input strength was varied by 10 fold. However, changing the duration of the perturbing stimulus shifted the PRC considerably. This implies that pacemaker neuron period is sensitive to input duration but not to input synaptic strength. RPCH may slow down the pyloric rhythm by acting on the pacemaker group directly.
520 $a The actions of some of the other modulators found in the neuropil of the STG (dopamine, histamine, Ala13-orcokinin, proctolin and TNRNFLRFamide) on the pyloric network were also studied.
590 $a School code: 0021.
650 4 $a Biology, Neuroscience. $3 1017680
650 4 $a Biology, Animal Physiology. $3 1017835
690 $a 0317
690 $a 0433
710 2 0 $a Brandeis University. $3 1017415
773 0 $t Dissertation Abstracts International $g 63-03B.
790 1 0 $a Marder, Eve, $e advisor
790 $a 0021
791 $a Ph.D.
792 $a 2002
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3045912