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Postnatal development of nigral dopa...

Lewis, Mark William.

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Postnatal development of nigral dopamine containing neurons: Electrophysiological studies in vitro.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Postnatal development of nigral dopamine containing neurons: Electrophysiological studies in vitro./
Author:	Lewis, Mark William.
Description:	158 p.
Notes:	Source: Dissertation Abstracts International, Volume: 61-01, Section: B, page: 0210.
Contained By:	Dissertation Abstracts International61-01B.
Subject:	Health Sciences, Pharmacology. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=9954208
ISBN:	0599583223

Postnatal development of nigral dopamine containing neurons: Electrophysiological studies in vitro.
Lewis, Mark William.

Postnatal development of nigral dopamine containing neurons: Electrophysiological studies in vitro. - 158 p.

Source: Dissertation Abstracts International, Volume: 61-01, Section: B, page: 0210.

Thesis (Ph.D.)--Wayne State University, 1999.

Midbrain dopamine (DA) neurons discharge in a single-spike and burst discharge mode in vivo. The discharge rate and the prevalence of the burst-discharge pattern increases in an age-dependent fashion. DA neurons are also spontaneously active in vitro. However, the in vitro discharge rate and pattern is very different from the pattern that is observed in vivo. In vitro, the discharge pattern is almost exclusively limited to a regular single-spike or pacemaker mode. Only rarely have DA neurons been observed to display burst-discharges in the midbrain slice preparation. The action potential discharge rate increases, and the discharge pattern becomes more regular in an age-dependent fashion during postnatal development. Increases in intracellular cAMP concentration elicited responses characterized as excited, inhibited, or biphasic (excited and inhibited). An increase in intracellular cAMP elicited by forskolin or 8-Br-cAMP was shown to change the discharge pattern of immature DA neurons discharging in an irregular discharge pattern to a pacemaker-like discharge pattern similar to that observed in more mature DA neurons. Increases in intracellular cAMP caused depolarization and in some cases the DA neurons switched to a burst-discharge mode. The effects mediated by 8-Br-cAMP and forskolin on DA neurons were found to have an age-dependent component. The age-dependent aspect of the responses suggests that the adenylate cyclase system may still be undergoing developmental changes during the postnatal period.

ISBN: 0599583223Subjects--Topical Terms:

1017717
Health Sciences, Pharmacology.

Postnatal development of nigral dopamine containing neurons: Electrophysiological studies in vitro.
LDR:03170nmm 2200301 4500 001 1817839
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008 130610s1999 eng d
020 $a 0599583223
035 $a (UnM)AAI9954208
035 $a AAI9954208
040 $a UnM $c UnM
100 1 $a Lewis, Mark William. $3 1907184
245 1 0 $a Postnatal development of nigral dopamine containing neurons: Electrophysiological studies in vitro.
300 $a 158 p.
500 $a Source: Dissertation Abstracts International, Volume: 61-01, Section: B, page: 0210.
500 $a Adviser: David K. Pitts.
502 $a Thesis (Ph.D.)--Wayne State University, 1999.
520 $a Midbrain dopamine (DA) neurons discharge in a single-spike and burst discharge mode in vivo. The discharge rate and the prevalence of the burst-discharge pattern increases in an age-dependent fashion. DA neurons are also spontaneously active in vitro. However, the in vitro discharge rate and pattern is very different from the pattern that is observed in vivo. In vitro, the discharge pattern is almost exclusively limited to a regular single-spike or pacemaker mode. Only rarely have DA neurons been observed to display burst-discharges in the midbrain slice preparation. The action potential discharge rate increases, and the discharge pattern becomes more regular in an age-dependent fashion during postnatal development. Increases in intracellular cAMP concentration elicited responses characterized as excited, inhibited, or biphasic (excited and inhibited). An increase in intracellular cAMP elicited by forskolin or 8-Br-cAMP was shown to change the discharge pattern of immature DA neurons discharging in an irregular discharge pattern to a pacemaker-like discharge pattern similar to that observed in more mature DA neurons. Increases in intracellular cAMP caused depolarization and in some cases the DA neurons switched to a burst-discharge mode. The effects mediated by 8-Br-cAMP and forskolin on DA neurons were found to have an age-dependent component. The age-dependent aspect of the responses suggests that the adenylate cyclase system may still be undergoing developmental changes during the postnatal period.
520 $a This is the first report of an endogenous second messenger causing a DA neuron to switch from the single-spike mode to the burst-discharge pattern. In SNC DA neurons, the c-AMP-mediated effects were observed as follows: (1) membrane depolarization, (2) increased conductance, and (3) decreased AHP amplitude. Evidence strongly suggests that excitation and most inhibitory responses are both mediated by depolarization. There is evidence to indicate that inhibition was, in some instances, mediated by hyperpolarization. The exact channels that are modulated by cAMP remain to be elucidated, however, preliminary evidence suggest the SK-type calcium-mediated potassium channel (IK(Ca)) is involved.
590 $a School code: 0254.
650 4 $a Health Sciences, Pharmacology. $3 1017717
650 4 $a Biology, Neuroscience. $3 1017680
650 4 $a Biology, Molecular. $3 1017719
690 $a 0419
690 $a 0317
690 $a 0307
710 2 0 $a Wayne State University. $3 975058
773 0 $t Dissertation Abstracts International $g 61-01B.
790 1 0 $a Pitts, David K., $e advisor
790 $a 0254
791 $a Ph.D.
792 $a 1999
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=9954208