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Regulation of uterine contractility.

Baguma-Nibasheka, Mark.

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Regulation of uterine contractility.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Regulation of uterine contractility./
Author:	Baguma-Nibasheka, Mark.
Description:	152 p.
Notes:	Source: Dissertation Abstracts International, Volume: 59-07, Section: B, page: 3156.
Contained By:	Dissertation Abstracts International59-07B.
Subject:	Biology, Animal Physiology. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=9838793
ISBN:	0591923963

Regulation of uterine contractility.
Baguma-Nibasheka, Mark.

Regulation of uterine contractility. - 152 p.

Source: Dissertation Abstracts International, Volume: 59-07, Section: B, page: 3156.

Thesis (Ph.D.)--Cornell University, 1998.

This research was a combined in vivo and in vitro study of the integration of factors regulating uterine contractility. We tested the effect of administration of betamethasone, a synthetic glucocorticoid, and nimesulide, a prostaglandin (PG) synthesis inhibitor, into nonpregnant sheep on in vitro myometrial responsiveness. Betamethasone increased spontaneous contactility and the response to PGE

ISBN: 0591923963Subjects--Topical Terms:

1017835
Biology, Animal Physiology.

Regulation of uterine contractility.
LDR:03276nmm 2200337 4500 001 1817817
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008 130610s1998 eng d
020 $a 0591923963
035 $a (UnM)AAI9838793
035 $a AAI9838793
040 $a UnM $c UnM
100 1 $a Baguma-Nibasheka, Mark. $3 1907162
245 1 0 $a Regulation of uterine contractility.
300 $a 152 p.
500 $a Source: Dissertation Abstracts International, Volume: 59-07, Section: B, page: 3156.
500 $a Adviser: Peter W. Nathanielsz.
502 $a Thesis (Ph.D.)--Cornell University, 1998.
520 $a This research was a combined in vivo and in vitro study of the integration of factors regulating uterine contractility. We tested the effect of administration of betamethasone, a synthetic glucocorticoid, and nimesulide, a prostaglandin (PG) synthesis inhibitor, into nonpregnant sheep on in vitro myometrial responsiveness. Betamethasone increased spontaneous contactility and the response to PGE $\ sb2 $ but not to PGF $\ sb{2\alpha} $ or oxytocin, indicating selective up-regulation of excitatory EP receptors. Nimesulide attenuated spontaneous contractility and sensitivity to oxytocin while increasing sensitivity to PGs, indicating down-regulation of oxytocin receptor and up-regulation of PG receptors.
520 $a Comparison of responses of myometrium and mesometrium from ovariectomized, pregnant or parturient ewes revealed an increase in myometrial activity preceding labor, suggesting that ovine myometrial activation occurs by 135 days of gestation; and a greater sensitivity of myometrium than mesometrium to PGs, supporting a major role for intrauterine paracrine factors.
520 $a To determine if acute infusions of omega-3 long chain polyunsaturates (n-3 LCPs) would inhibit preterm labor, emulsions of either Intralipid or n-3 LCPs were infused to pregnant ewes and betamethasone to the fetuses. The n-3 LCPs delayed premature delivery, indicating a possible tocolytic value.
520 $a Responses of myometrium from the fundus, anterior and posterior corpus and lower segment of the uterus in pregnant baboons showed that only fundus spontaneous contractility correlates with gestational age, implying a pacemaker role. PGE $\ sb2 $, PGF $\ sb{2\alpha} $ and oxytocin contracted myometrium from the fundus and corpus but only PGF $\ sb{2\alpha} $ contracted lower uterine segment. Sodium nitroprusside, forskolin and isoproterenol inhibited contractility in all regions. The response to sulprostone was equal in the four regions. The lower segment might therefore have more inhibitory EP receptors and fewer oxytocin receptors than other regions.
520 $a Iloprost, a prostacyclin analog, was shown to inhibit the contractility of lower segment myometrium taken from rhesus monkeys in normal-term or androstenedione-induced preterm labor but not that from monkeys not in labor, suggesting up-regulation of IP receptors and/or down-regulation of EP $\ sb1 $ receptors during labor.
590 $a School code: 0058.
650 4 $a Biology, Animal Physiology. $3 1017835
650 4 $a Biology, Veterinary Science. $3 1021733
650 4 $a Health Sciences, Obstetrics and Gynecology. $3 1020690
690 $a 0433
690 $a 0778
690 $a 0380
710 2 0 $a Cornell University. $3 530586
773 0 $t Dissertation Abstracts International $g 59-07B.
790 1 0 $a Nathanielsz, Peter W., $e advisor
790 $a 0058
791 $a Ph.D.
792 $a 1998
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=9838793