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The serotonin 5-HT(7) receptor: Cir...

Mullins, Ursula Lena.

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The serotonin 5-HT(7) receptor: Circadian rhythm regulation and mechanism of antidepressant action.

Record Type:	Electronic resources : Monograph/item
Title/Author:	The serotonin 5-HT(7) receptor: Circadian rhythm regulation and mechanism of antidepressant action./
Author:	Mullins, Ursula Lena.
Description:	120 p.
Notes:	Source: Dissertation Abstracts International, Volume: 59-01, Section: B, page: 0173.
Contained By:	Dissertation Abstracts International59-01B.
Subject:	Health Sciences, Pharmacology. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=9821921
ISBN:	0591736233

The serotonin 5-HT(7) receptor: Circadian rhythm regulation and mechanism of antidepressant action.
Mullins, Ursula Lena.

The serotonin 5-HT(7) receptor: Circadian rhythm regulation and mechanism of antidepressant action. - 120 p.

Source: Dissertation Abstracts International, Volume: 59-01, Section: B, page: 0173.

Thesis (Ph.D.)--University of Connecticut, 1997.

Circadian rhythm disturbances are often associated with affective disorders and it has been suggested that rhythm dysregulation may play a role in the pathophysiology of depression. Furthermore, it has been demonstrated that serotonergics, including antidepressants, shift rhythmic circadian functions in-vitro and in-vivo. The specific serotonergic receptor mechanisms invoked in the modulation of circadian rhythms, however, are not clear.

ISBN: 0591736233Subjects--Topical Terms:

1017717
Health Sciences, Pharmacology.

The serotonin 5-HT(7) receptor: Circadian rhythm regulation and mechanism of antidepressant action.
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020 $a 0591736233
035 $a (UnM)AAI9821921
035 $a AAI9821921
040 $a UnM $c UnM
100 1 $a Mullins, Ursula Lena. $3 1907155
245 1 4 $a The serotonin 5-HT(7) receptor: Circadian rhythm regulation and mechanism of antidepressant action.
300 $a 120 p.
500 $a Source: Dissertation Abstracts International, Volume: 59-01, Section: B, page: 0173.
500 $a Adviser: G. Gianutsos.
502 $a Thesis (Ph.D.)--University of Connecticut, 1997.
520 $a Circadian rhythm disturbances are often associated with affective disorders and it has been suggested that rhythm dysregulation may play a role in the pathophysiology of depression. Furthermore, it has been demonstrated that serotonergics, including antidepressants, shift rhythmic circadian functions in-vitro and in-vivo. The specific serotonergic receptor mechanisms invoked in the modulation of circadian rhythms, however, are not clear.
520 $a A novel serotonin receptor, 5-HT $\ sb7, $ has recently been cloned and localized to the hypothalamus, site of the biological pacemaker--the suprachiasmatic nucleus. This receptor also has a high distribution within other areas of the limbic system, particularly the hippocampus, possibly implicating the 5-HT $\ sb7 $ receptor in the pathology of depression. In the absence of subtype selective ligands, action at the 5-HT $\ sb7 $ receptor is currently defined as activation by the endogenous ligand serotonin in the presence of the 5-HT $\ rm\sb{1A} $ antagonist ( $- $) pindolol and the 5-HT $\ rm\sb{1D} $ agonist sumatriptan.
520 $a This work hypothesizes that the 5-HT $\ sb7 $ receptor is involved in serotonergic regulation of circadian rhythmicity and is mechanistically implicated in post-synaptic actions of antidepressant treatment. Circadian hypothalamic and limbic hippocampal in-vitro responses to agents or antidepressants consistent with 5-HT $\ sb7 $ receptor pharmacology were investigated using: Fos immunohistochemistry as a marker of neuronal activation and 5-HT $\ sb7 $ receptor binding as a measure of receptor regulation changes. In addition, the excretion response curve of 6-sulfatoxymelatonin, a measure reflective of in-vivo circadian rhythmicity, was also used to monitor drug effects.
520 $a The results obtained in these investigations suggest that Fos expression in the hypothalamus and hippocampus is acutely induced in response to serotonergic agents, including antidepressants, in a profile consistent with the 5-HT $\ sb7 $ receptor and that these responses are desensitized after chronic administration. These functional results correlated with a neuroadaptive reduction in the number of 5-HT $\ sb7 $ receptors in the hypothalamus and hippocampus of chronically treated animals. Furthermore, chronic treatments pharmacologically consistent with 5-HT $\ sb7 $ receptor activation produced alterations in aMT6s excretion profiles suggestive of a delayed shift in circadian phase.
520 $a Taken together, the results from the present studies accordingly support the hypotheses that the 5-HT $\ sb7 $ receptor is involved in the modulation of circadian rhythms and is implicated in the mechanism of action of antidepressants.
590 $a School code: 0056.
650 4 $a Health Sciences, Pharmacology. $3 1017717
650 4 $a Biology, Neuroscience. $3 1017680
650 4 $a Psychology, Psychobiology. $3 1017821
690 $a 0419
690 $a 0317
690 $a 0349
710 2 0 $a University of Connecticut. $3 1017435
773 0 $t Dissertation Abstracts International $g 59-01B.
790 1 0 $a Gianutsos, G., $e advisor
790 $a 0056
791 $a Ph.D.
792 $a 1997
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=9821921