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Models of circadian and homeostatic ...

Jewett, Megan Elizabeth.

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Models of circadian and homeostatic regulation of human performance and alertness.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Models of circadian and homeostatic regulation of human performance and alertness./
Author:	Jewett, Megan Elizabeth.
Description:	266 p.
Notes:	Source: Dissertation Abstracts International, Volume: 58-05, Section: B, page: 2532.
Contained By:	Dissertation Abstracts International58-05B.
Subject:	Engineering, Biomedical. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=9733327
ISBN:	0591427869

Models of circadian and homeostatic regulation of human performance and alertness.
Jewett, Megan Elizabeth.

Models of circadian and homeostatic regulation of human performance and alertness. - 266 p.

Source: Dissertation Abstracts International, Volume: 58-05, Section: B, page: 2532.

Thesis (Ph.D.)--Harvard University, 1997.

In this dissertation, mathematical models of subjective alertness and cognitive performance which incorporate the effects of light on the circadian system as well as the non-linear interaction observed between the homeostatic component and the amplitude of the circadian component were constructed, refined, and validated.

ISBN: 0591427869Subjects--Topical Terms:

1017684
Engineering, Biomedical.

Models of circadian and homeostatic regulation of human performance and alertness.
LDR:03317nmm 2200325 4500 001 1817803
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020 $a 0591427869
035 $a (UnM)AAI9733327
035 $a AAI9733327
040 $a UnM $c UnM
100 1 $a Jewett, Megan Elizabeth. $3 1907148
245 1 0 $a Models of circadian and homeostatic regulation of human performance and alertness.
300 $a 266 p.
500 $a Source: Dissertation Abstracts International, Volume: 58-05, Section: B, page: 2532.
500 $a Chair: Richard E. Kronauer.
502 $a Thesis (Ph.D.)--Harvard University, 1997.
520 $a In this dissertation, mathematical models of subjective alertness and cognitive performance which incorporate the effects of light on the circadian system as well as the non-linear interaction observed between the homeostatic component and the amplitude of the circadian component were constructed, refined, and validated.
520 $a In studies conducted to investigate the effects of bright light on the human circadian pacemaker, we found that a 1-cycle stimulus induced type 1 resetting, a 2-cycle stimulus induced critical resetting, and a 3-cycle stimulus induced type 0 resetting. These experiments were used to refine Kronauer's mathematical model of the effects of light on the human circadian system. In the revised model, a direct effect of light onto the period of the pacemaker was added, and the amplitude recovery function of the van der Pol oscillator was replaced by a higher order function so that recovery was slower near the singularity and faster near the limit cycle.
520 $a Experiments were conducted to investigate each of the three major components originally proposed by Folkard and Akerstedt to regulate alertness and performance: sleep inertia; circadian rhythms; and a sleep/wake homeostat. We found that sleep inertia dissipated in an asymptotic manner and alertness and performance were impaired for more than an hour after awakening. The homeostatic and circadian components and their interactions were characterized using data from $\ sim $2 00 constant routines initiated across all circadian phases. The homeostatic component declined during wakefulness in a Gaussian manner, with slower rates of decline during the first $\ sim $1 0 h and after $\ sim $3 0 h of wakefulness. The circadian component was sinusoidal, with a minimum $\ sim $1 .4 h after the fitted temperature minimum. The amplitude of the circadian component rose in a saturating exponential manner as the homeostatic component declined. Finally, dose response curves to sleep characterizing the recovery of alertness and performance rose in an asymptotic manner.
520 $a These data were used to construct mathematical models of alertness and performance. The models were refined using data from $\ sim $1 50 constant routines that began at the subjects' habitual waketimes. The models were validated using data from a circadian amplitude suppression study and a 42.85 h forced desynchrony study.
590 $a School code: 0084.
650 4 $a Engineering, Biomedical. $3 1017684
650 4 $a Biology, Animal Physiology. $3 1017835
650 4 $a Psychology, Physiological. $3 1017869
690 $a 0541
690 $a 0433
690 $a 0989
710 2 0 $a Harvard University. $3 528741
773 0 $t Dissertation Abstracts International $g 58-05B.
790 1 0 $a Kronauer, Richard E., $e advisor
790 $a 0084
791 $a Ph.D.
792 $a 1997
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=9733327