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Statics and dynamics of DNA in nanof...

Reisner, Walter W.

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Statics and dynamics of DNA in nanofabricated devices.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Statics and dynamics of DNA in nanofabricated devices./
Author:	Reisner, Walter W.
Description:	124 p.
Notes:	Source: Dissertation Abstracts International, Volume: 67-01, Section: B, page: 0139.
Contained By:	Dissertation Abstracts International67-01B.
Subject:	Biophysics, General. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3206547
ISBN:	054252984X

Statics and dynamics of DNA in nanofabricated devices.
Reisner, Walter W.

Statics and dynamics of DNA in nanofabricated devices. - 124 p.

Source: Dissertation Abstracts International, Volume: 67-01, Section: B, page: 0139.

Thesis (Ph.D.)--Princeton University, 2006.

The successful design of nanofluidic devices for the manipulation of biopolymers requires an understanding of how the predictions of soft condensed matter physics scale with device dimensions. For dsDNA confined in nanochannels below a critical width roughly twice the persistence length, there is a cross-over in the fundamental physics: a transition occurs between a regime dominated by self-exclusion interactions and a regime dominated by bending rigidity. Using a combination of electron beam lithography (EBL) and nano imprint lithography (NIL) channels have been fabricated that vary in width from 400nm down to 30 nm. The cross-over scale is identified by measuring the extension of DNA as a function of width: above the critical width, the stretch versus width curve has a power-law behavior which we identify with the self-exclusion regime. Below the crossover length, we observe a deviation from the self-exclusion power-law consistent with a theory developed by T. Odijk. The Brownian fluctuations of the confined DNA, which are critical for single molecule sequencing techniques, were also measured as a function of channel width. The relaxation time of the fluctuations exhibits a novel non-monotonic width-dependence: the relaxation time is maximized at the cross-over width.

ISBN: 054252984XSubjects--Topical Terms:

1019105
Biophysics, General.

Statics and dynamics of DNA in nanofabricated devices.
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008 130610s2006 eng d
020 $a 054252984X
035 $a (UnM)AAI3206547
035 $a AAI3206547
040 $a UnM $c UnM
100 1 $a Reisner, Walter W. $3 1906963
245 1 0 $a Statics and dynamics of DNA in nanofabricated devices.
300 $a 124 p.
500 $a Source: Dissertation Abstracts International, Volume: 67-01, Section: B, page: 0139.
500 $a Adviser: Robert H. Austin.
502 $a Thesis (Ph.D.)--Princeton University, 2006.
520 $a The successful design of nanofluidic devices for the manipulation of biopolymers requires an understanding of how the predictions of soft condensed matter physics scale with device dimensions. For dsDNA confined in nanochannels below a critical width roughly twice the persistence length, there is a cross-over in the fundamental physics: a transition occurs between a regime dominated by self-exclusion interactions and a regime dominated by bending rigidity. Using a combination of electron beam lithography (EBL) and nano imprint lithography (NIL) channels have been fabricated that vary in width from 400nm down to 30 nm. The cross-over scale is identified by measuring the extension of DNA as a function of width: above the critical width, the stretch versus width curve has a power-law behavior which we identify with the self-exclusion regime. Below the crossover length, we observe a deviation from the self-exclusion power-law consistent with a theory developed by T. Odijk. The Brownian fluctuations of the confined DNA, which are critical for single molecule sequencing techniques, were also measured as a function of channel width. The relaxation time of the fluctuations exhibits a novel non-monotonic width-dependence: the relaxation time is maximized at the cross-over width.
590 $a School code: 0181.
650 4 $a Biophysics, General. $3 1019105
650 4 $a Physics, Condensed Matter. $3 1018743
690 $a 0786
690 $a 0611
710 2 0 $a Princeton University. $3 645579
773 0 $t Dissertation Abstracts International $g 67-01B.
790 1 0 $a Austin, Robert H., $e advisor
790 $a 0181
791 $a Ph.D.
792 $a 2006
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3206547