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Analyses and comparison of a novel, ...

DiCicco, Michael.

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Analyses and comparison of a novel, hybrid, multifunctional orthopedic composite and implant.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Analyses and comparison of a novel, hybrid, multifunctional orthopedic composite and implant./
Author:	DiCicco, Michael.
Description:	267 p.
Notes:	Source: Dissertation Abstracts International, Volume: 66-05, Section: B, page: 2557.
Contained By:	Dissertation Abstracts International66-05B.
Subject:	Chemistry, Analytical. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3176822
ISBN:	0542160684

Analyses and comparison of a novel, hybrid, multifunctional orthopedic composite and implant.
DiCicco, Michael.

Analyses and comparison of a novel, hybrid, multifunctional orthopedic composite and implant. - 267 p.

Source: Dissertation Abstracts International, Volume: 66-05, Section: B, page: 2557.

Thesis (Ph.D.)--Temple University, 2005.

In the orthopedic/medical device industry, 2, 2' -bis-(4-(2-hydroxy-3-methacryloxypropoxy)phenyl]propane (Bis-GMA)- and diurethanedimethacrylate (DUDMA)-based polymeric biomaterials have become well-known substitutes for polymethylmethacrylate (PMMA)- and ultra-high molecular weight polyethylene (UHMWPE)-based biomaterials, respectively. The development of these polymeric biomaterials cannot continue without direct comparison studies against currently marketed materials. The initiative for this research stems wholly from developing analytical methodologies that assist in qualifying novel biomaterials under development, by evaluating their chemical properties, performance, and safety.

ISBN: 0542160684Subjects--Topical Terms:

586156
Chemistry, Analytical.

Analyses and comparison of a novel, hybrid, multifunctional orthopedic composite and implant.
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100 1 $a DiCicco, Michael. $3 1906406
245 1 0 $a Analyses and comparison of a novel, hybrid, multifunctional orthopedic composite and implant.
300 $a 267 p.
500 $a Source: Dissertation Abstracts International, Volume: 66-05, Section: B, page: 2557.
500 $a Chair: Stephanie L. Wunder.
502 $a Thesis (Ph.D.)--Temple University, 2005.
520 $a In the orthopedic/medical device industry, 2, 2' -bis-(4-(2-hydroxy-3-methacryloxypropoxy)phenyl]propane (Bis-GMA)- and diurethanedimethacrylate (DUDMA)-based polymeric biomaterials have become well-known substitutes for polymethylmethacrylate (PMMA)- and ultra-high molecular weight polyethylene (UHMWPE)-based biomaterials, respectively. The development of these polymeric biomaterials cannot continue without direct comparison studies against currently marketed materials. The initiative for this research stems wholly from developing analytical methodologies that assist in qualifying novel biomaterials under development, by evaluating their chemical properties, performance, and safety.
520 $a The goals of this research were: (i) Characterize the assay/quality of every resin component and quantify elution of extractable monomers from novel, DUDMA-based RHAKOSS(TM) implant, (ii) Determine degree of conversion (alpha) and rate of polymerization (Rp) for novel, Bis-GMA-based CORTOSS(TM) composite, (iii) Assess risk for radical-induced post-surgical cytotoxicity for CORTOSS, (iv) Determine if surface radical chemistries occur for sterilized RHAKOSS and assess its oxidative stability, and (v) Quantify antibiotic elution from antibiotic-impregnated CORTOSS and identify factors that control elution. The phenomena studied necessitated the utilization of several analytical spectroscopic techniques; fluorometry, differential scanning calorimetry (DSC), electron paramagnetic resonance (EPR), ultraviolet-visible (UV-VIS), attenuated total reflectance---Fourier-transform infrared (ATR-FTIR), and high performance liquid chromatography (HPLC). A battery of lateral chemical techniques were employed as well; including molecular derivatization/tagging, phase partitioning, spin-trapping, and thermal annealing.
520 $a Results demonstrated that RHAKOSS monomer percent compositions were prepared according to formulations and monomer elution was virtually undetectable, serving as an empirical gauge to portend degree of polymerization (DOP). A high alpha was reported for CORTOSS and essentially all bifunctional monomers had at least one functional group polymerized, stressing low monomer elution potential. Regarding cytotoxicity, CORTOSS impeded further production of hydroxyl radicals (•OH), whereas RHAKOSS did not facilitate the Fenton reaction but displayed some chelating abilities. Residual radicals in RHAKOSS were easily terminated, thus not projected to form oxidative degradants. Additionally, significant antibiotic concentrations, over extended durations, eluted from CORTOSS in linear-type fashion, advocating a sustained therapeutic effect, and phase partitioning correlated antibiotic release to hydrophilicity. The incurred data comprehensively argues in favor of the excellent biocompatibility that CORTOSS and RHAKOSS inherently possess, and was definitive in rendering them as advanced biomaterials, possessing favorable chemical properties.
590 $a School code: 0225.
650 4 $a Chemistry, Analytical. $3 586156
650 4 $a Engineering, Biomedical. $3 1017684
650 4 $a Engineering, Materials Science. $3 1017759
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710 2 0 $a Temple University. $3 959342
773 0 $t Dissertation Abstracts International $g 66-05B.
790 1 0 $a Wunder, Stephanie L., $e advisor
790 $a 0225
791 $a Ph.D.
792 $a 2005
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3176822