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Infrequent androgen receptor mutatio...

Wantroba, Marcus Allan.

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Infrequent androgen receptor mutations in primary prostate tumors from men residing in Singapore and Los Angeles (California, China).

Record Type:	Electronic resources : Monograph/item
Title/Author:	Infrequent androgen receptor mutations in primary prostate tumors from men residing in Singapore and Los Angeles (California, China)./
Author:	Wantroba, Marcus Allan.
Description:	107 p.
Notes:	Source: Masters Abstracts International, Volume: 44-03, page: 1273.
Contained By:	Masters Abstracts International44-03.
Subject:	Biology, Biostatistics. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=1430408
ISBN:	0542433265

Infrequent androgen receptor mutations in primary prostate tumors from men residing in Singapore and Los Angeles (California, China).
Wantroba, Marcus Allan.

Infrequent androgen receptor mutations in primary prostate tumors from men residing in Singapore and Los Angeles (California, China). - 107 p.

Source: Masters Abstracts International, Volume: 44-03, page: 1273.

Thesis (M.S.)--University of Southern California, 2005.

We performed case-only studies of African-American, Latino, and Chinese men in order to: (i) Assess the frequency of androgen receptor (AR) somatic mutations in prostate tumors from who have not received androgen ablation therapy and: (ii) Investigate the associations between AR-CAG repeat length and tumor characteristics. Additionally, we performed a case-control analysis to estimate PCa risk associated with PCa and AR-CAG repeat length in Chinese men. AR mutations occurred extremely infrequently in primary tumors from men who have not undergone androgen ablation therapy, which indicates limited etiological role. However, significant associations were obtained between AR-CAG repeat lengths and Gleason Grade, as well as age at diagnosis, in African-American and Latino men. No significant association between AR-CAG repeat length and disease risk in Chinese men was observed. We conclude that although germline AR-CAG variation is involved in PCa progression, somatic mutations in the AR play virtually no role in untreated PCa.

ISBN: 0542433265Subjects--Topical Terms:

1018416
Biology, Biostatistics.

Infrequent androgen receptor mutations in primary prostate tumors from men residing in Singapore and Los Angeles (California, China).
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100 1 $a Wantroba, Marcus Allan. $3 1906327
245 1 0 $a Infrequent androgen receptor mutations in primary prostate tumors from men residing in Singapore and Los Angeles (California, China).
300 $a 107 p.
500 $a Source: Masters Abstracts International, Volume: 44-03, page: 1273.
500 $a Adviser: Gerhard Coetzee.
502 $a Thesis (M.S.)--University of Southern California, 2005.
520 $a We performed case-only studies of African-American, Latino, and Chinese men in order to: (i) Assess the frequency of androgen receptor (AR) somatic mutations in prostate tumors from who have not received androgen ablation therapy and: (ii) Investigate the associations between AR-CAG repeat length and tumor characteristics. Additionally, we performed a case-control analysis to estimate PCa risk associated with PCa and AR-CAG repeat length in Chinese men. AR mutations occurred extremely infrequently in primary tumors from men who have not undergone androgen ablation therapy, which indicates limited etiological role. However, significant associations were obtained between AR-CAG repeat lengths and Gleason Grade, as well as age at diagnosis, in African-American and Latino men. No significant association between AR-CAG repeat length and disease risk in Chinese men was observed. We conclude that although germline AR-CAG variation is involved in PCa progression, somatic mutations in the AR play virtually no role in untreated PCa.
590 $a School code: 0208.
650 4 $a Biology, Biostatistics. $3 1018416
650 4 $a Health Sciences, Public Health. $3 1017659
690 $a 0308
690 $a 0573
710 2 0 $a University of Southern California. $3 700129
773 0 $t Masters Abstracts International $g 44-03.
790 1 0 $a Coetzee, Gerhard, $e advisor
790 $a 0208
791 $a M.S.
792 $a 2005
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=1430408