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Function analysis of viral glycoprot...

Jiang, Haiqing.

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Function analysis of viral glycoprotein in viral infection.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Function analysis of viral glycoprotein in viral infection./
Author:	Jiang, Haiqing.
Description:	98 p.
Notes:	Source: Dissertation Abstracts International, Volume: 65-11, Section: B, page: 5535.
Contained By:	Dissertation Abstracts International65-11B.
Subject:	Biology, Microbiology. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3154423
ISBN:	0496149199

Function analysis of viral glycoprotein in viral infection.
Jiang, Haiqing.

Function analysis of viral glycoprotein in viral infection. - 98 p.

Source: Dissertation Abstracts International, Volume: 65-11, Section: B, page: 5535.

Thesis (Ph.D.)--University of Illinois at Chicago, Health Sciences Center, 2005.

Ebola viruses are enveloped, nonsegmented, negative-stranded RNA viruses. Together with Marburg viruses, they are classified in the order of Mononegavirales and the family of Filoviridae. Ebola GP2 protein, which is a type I viral fusion protein, mediates virus-host membrane fusion. The role of the charged residues in the function of Ebola GP2 was evaluated by a HIV-based pseudotyping system. We found that several charged residues are important for GP2 function. In contrast a similar analysis of the charged residues of HIV-1 gp41 showed different effect from Ebola GP2, especially in C-helix. These results suggest that the charged residues of Ebola GP2 may participate in the formation of fusion-active GP2 conformation or play a role in GP2 intermediate status in fusion process. We also demonstrate that Ebola GP2 played an active role in virus release by characterizing a gain-of-function Ebola GP2 mutant. We showed the enhanced infectivity probably resulted from the newly acquired GP2 association with raft-like lipid microdomains during virus budding.

ISBN: 0496149199Subjects--Topical Terms:

1017734
Biology, Microbiology.

Function analysis of viral glycoprotein in viral infection.
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100 1 $a Jiang, Haiqing. $3 1905515
245 1 0 $a Function analysis of viral glycoprotein in viral infection.
300 $a 98 p.
500 $a Source: Dissertation Abstracts International, Volume: 65-11, Section: B, page: 5535.
500 $a Chair: Lijun Rong.
502 $a Thesis (Ph.D.)--University of Illinois at Chicago, Health Sciences Center, 2005.
520 $a Ebola viruses are enveloped, nonsegmented, negative-stranded RNA viruses. Together with Marburg viruses, they are classified in the order of Mononegavirales and the family of Filoviridae. Ebola GP2 protein, which is a type I viral fusion protein, mediates virus-host membrane fusion. The role of the charged residues in the function of Ebola GP2 was evaluated by a HIV-based pseudotyping system. We found that several charged residues are important for GP2 function. In contrast a similar analysis of the charged residues of HIV-1 gp41 showed different effect from Ebola GP2, especially in C-helix. These results suggest that the charged residues of Ebola GP2 may participate in the formation of fusion-active GP2 conformation or play a role in GP2 intermediate status in fusion process. We also demonstrate that Ebola GP2 played an active role in virus release by characterizing a gain-of-function Ebola GP2 mutant. We showed the enhanced infectivity probably resulted from the newly acquired GP2 association with raft-like lipid microdomains during virus budding.
590 $a School code: 0806.
650 4 $a Biology, Microbiology. $3 1017734
650 4 $a Biology, Molecular. $3 1017719
650 4 $a Health Sciences, Immunology. $3 1017716
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710 2 0 $a University of Illinois at Chicago, Health Sciences Center. $3 1021703
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790 $a 0806
791 $a Ph.D.
792 $a 2005
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3154423