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Quantitative measurement of cell mem...

Kasson, Peter M.

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Quantitative measurement of cell membrane protein redistribution.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Quantitative measurement of cell membrane protein redistribution./
Author:	Kasson, Peter M.
Description:	152 p.
Notes:	Source: Dissertation Abstracts International, Volume: 66-01, Section: B, page: 0155.
Contained By:	Dissertation Abstracts International66-01B.
Subject:	Biophysics, General. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3162385
ISBN:	0496964496

Quantitative measurement of cell membrane protein redistribution.
Kasson, Peter M.

Quantitative measurement of cell membrane protein redistribution. - 152 p.

Source: Dissertation Abstracts International, Volume: 66-01, Section: B, page: 0155.

Thesis (Ph.D.)--Stanford University, 2005.

Polarized cell membrane reorganization is a fundamental cellular process that plays a critical role in directional responses for cell signaling and effector function in a number of contexts. Quantitative measurement methods are needed in order to systematically assess membrane protein redistribution in these polarized cellular responses. Quantitative methods are also necessary for statistical analyses, the testing of physical hypotheses regarding rearrangement mechanisms, and ultimately the development of predictive models. I have developed integrated surface-based methods for the quantitative analysis of membrane protein redistribution using fluorescence microscopy data as a source of protein localization information. These methods enable quantitative analysis in a more robust, accurate, and automated fashion than previously possible. I also report the application of these methods to the study of protein redistribution in T lymphocyte activation.

ISBN: 0496964496Subjects--Topical Terms:

1019105
Biophysics, General.

Quantitative measurement of cell membrane protein redistribution.
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100 1 $a Kasson, Peter M. $3 1905369
245 1 0 $a Quantitative measurement of cell membrane protein redistribution.
300 $a 152 p.
500 $a Source: Dissertation Abstracts International, Volume: 66-01, Section: B, page: 0155.
500 $a Adviser: Axel Brunger.
502 $a Thesis (Ph.D.)--Stanford University, 2005.
520 $a Polarized cell membrane reorganization is a fundamental cellular process that plays a critical role in directional responses for cell signaling and effector function in a number of contexts. Quantitative measurement methods are needed in order to systematically assess membrane protein redistribution in these polarized cellular responses. Quantitative methods are also necessary for statistical analyses, the testing of physical hypotheses regarding rearrangement mechanisms, and ultimately the development of predictive models. I have developed integrated surface-based methods for the quantitative analysis of membrane protein redistribution using fluorescence microscopy data as a source of protein localization information. These methods enable quantitative analysis in a more robust, accurate, and automated fashion than previously possible. I also report the application of these methods to the study of protein redistribution in T lymphocyte activation.
590 $a School code: 0212.
650 4 $a Biophysics, General. $3 1019105
690 $a 0786
710 2 0 $a Stanford University. $3 754827
773 0 $t Dissertation Abstracts International $g 66-01B.
790 1 0 $a Brunger, Axel, $e advisor
790 $a 0212
791 $a Ph.D.
792 $a 2005
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3162385