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Surface desensitization of polarimet...

Worth, Colin.

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Surface desensitization of polarimetric waveguide interferometers.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Surface desensitization of polarimetric waveguide interferometers./
Author:	Worth, Colin.
Description:	164 p.
Notes:	Source: Dissertation Abstracts International, Volume: 65-12, Section: B, page: 6458.
Contained By:	Dissertation Abstracts International65-12B.
Subject:	Physics, Optics. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3157420
ISBN:	0496904329

Surface desensitization of polarimetric waveguide interferometers.
Worth, Colin.

Surface desensitization of polarimetric waveguide interferometers. - 164 p.

Source: Dissertation Abstracts International, Volume: 65-12, Section: B, page: 6458.

Thesis (Ph.D.)--Boston University, 2005.

Non-specific binding of small molecules to the surface of waveguide biosensors presents a major obstacle to surface-sensing techniques that attempt to detect very low concentrations (<1 g/mm2) of large (500 nm to 3 mum) biological objects. Interferometric waveguide biosensors use the interaction of an evanescent light field outside of the guiding layer with a biological sample to detect a particular type of cell or bacteria at some distance from the sensor surface. In such experiments, binding of small proteins close to the surface can be a significant source of noise. It is possible to significantly improve the signal-to-noise ratio by varying the properties of the biosensor, in order to reduce or eliminate the biosensor's response to a thin protein layer at the waveguide surface, without significantly reducing the response to larger target particles.

ISBN: 0496904329Subjects--Topical Terms:

1018756
Physics, Optics.

Surface desensitization of polarimetric waveguide interferometers.
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020 $a 0496904329
035 $a (UnM)AAI3157420
035 $a AAI3157420
040 $a UnM $c UnM
100 1 $a Worth, Colin. $3 1905364
245 1 0 $a Surface desensitization of polarimetric waveguide interferometers.
300 $a 164 p.
500 $a Source: Dissertation Abstracts International, Volume: 65-12, Section: B, page: 6458.
500 $a Major Adviser: Bennett B. Goldberg.
502 $a Thesis (Ph.D.)--Boston University, 2005.
520 $a Non-specific binding of small molecules to the surface of waveguide biosensors presents a major obstacle to surface-sensing techniques that attempt to detect very low concentrations (<1 g/mm2) of large (500 nm to 3 mum) biological objects. Interferometric waveguide biosensors use the interaction of an evanescent light field outside of the guiding layer with a biological sample to detect a particular type of cell or bacteria at some distance from the sensor surface. In such experiments, binding of small proteins close to the surface can be a significant source of noise. It is possible to significantly improve the signal-to-noise ratio by varying the properties of the biosensor, in order to reduce or eliminate the biosensor's response to a thin protein layer at the waveguide surface, without significantly reducing the response to larger target particles.
520 $a In many biosensing applications, specifically bound particles, such as bacteria, are much larger than non-specifically bound particles such as proteins. In addition, due to laminar flow conditions at the sensor surface, the latter smaller particles tend to accumulate on the sensor surface. By varying the waveguide parameters, it is possible to vary the sensitivity of the detector response as a function of sample distance from the detector, by changing the properties of the TE0 and TM0 guided modes. This results in a signal reduction of more than 85%, for thin (30 nm or less) layers adjacent to the waveguide surface.
590 $a School code: 0017.
650 4 $a Physics, Optics. $3 1018756
650 4 $a Biophysics, General. $3 1019105
650 4 $a Biophysics, Medical. $3 1017681
690 $a 0752
690 $a 0786
690 $a 0760
710 2 0 $a Boston University. $3 1017454
773 0 $t Dissertation Abstracts International $g 65-12B.
790 1 0 $a Goldberg, Bennett B., $e advisor
790 $a 0017
791 $a Ph.D.
792 $a 2005
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3157420