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The use of liquid chromatography cou...

Moore, Kimberly Dawn.

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The use of liquid chromatography coupled to tandem mass spectrometry for the quantitation of pharmaceuticals and biological analytes in complex samples.

Record Type:	Electronic resources : Monograph/item
Title/Author:	The use of liquid chromatography coupled to tandem mass spectrometry for the quantitation of pharmaceuticals and biological analytes in complex samples./
Author:	Moore, Kimberly Dawn.
Description:	203 p.
Notes:	Source: Dissertation Abstracts International, Volume: 65-10, Section: B, page: 5121.
Contained By:	Dissertation Abstracts International65-10B.
Subject:	Chemistry, Analytical. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3150393
ISBN:	0496099884

The use of liquid chromatography coupled to tandem mass spectrometry for the quantitation of pharmaceuticals and biological analytes in complex samples.
Moore, Kimberly Dawn.

The use of liquid chromatography coupled to tandem mass spectrometry for the quantitation of pharmaceuticals and biological analytes in complex samples. - 203 p.

Source: Dissertation Abstracts International, Volume: 65-10, Section: B, page: 5121.

Thesis (Ph.D.)--The University of Kansas, 2004.

Efforts toward the development of methods to separate, detect, and quantitate pharmaceutical compounds and biological analytes in complex matrices using liquid chromatography-tandem mass spectrometry (LC/MS/MS) are described. The research discussed herein covers environmental, bioanalytical, and metabonomic applications.

ISBN: 0496099884Subjects--Topical Terms:

586156
Chemistry, Analytical.

The use of liquid chromatography coupled to tandem mass spectrometry for the quantitation of pharmaceuticals and biological analytes in complex samples.
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040 $a UnM $c UnM
100 1 $a Moore, Kimberly Dawn. $3 1905045
245 1 4 $a The use of liquid chromatography coupled to tandem mass spectrometry for the quantitation of pharmaceuticals and biological analytes in complex samples.
300 $a 203 p.
500 $a Source: Dissertation Abstracts International, Volume: 65-10, Section: B, page: 5121.
500 $a Chair: Craig E. Lunte.
502 $a Thesis (Ph.D.)--The University of Kansas, 2004.
520 $a Efforts toward the development of methods to separate, detect, and quantitate pharmaceutical compounds and biological analytes in complex matrices using liquid chromatography-tandem mass spectrometry (LC/MS/MS) are described. The research discussed herein covers environmental, bioanalytical, and metabonomic applications.
520 $a The goal of the environmental application was to determine pharmaceutical compound concentrations in sewage, river, and tap water following concentration and cleanup using solid phase extraction (SPE) and LC/MS/MS. Five basic pharmaceuticals and two neutral pharmaceuticals were confirmed to be present in the environmental samples using a LC/MS/MS product ion scan. The concentrations of the pharmaceuticals were determined using a multiple reaction monitoring (MRM) analysis and a deuterated internal standard.
520 $a The bioanalytical application objectives were two fold: (i) to monitor the skin penetration of EsteromRTM components using dermal microdialysis and LC/MS/MS MRM analysis, (ii) to detect metabolites collected by intravenous microdialysis in a rat using an LC/MS/MS MRM analysis, after a subcutaneous dose of one EsteromRTM component (an esterified metabolite of cocaine) thought to possess anesthetic properties. The topically applied components of EsteromRTM were found to penetrate at low concentrations and a large variation in penetrating concentrations was observed. After a subcutaneous dose of the target analyte, systemic exposure to the dosed compound and further metabolites was observed.
520 $a The purpose of the metabonomic-based investigation was to develop a screening method for determining nucleosides and modified nucleosides in urine SPE extracts using an LC/MS/MS neutral loss scan. Urine from a male smoker and a male non-smoker were subjected to SPE and the extracts were analyzed to demonstrate the utility of this screening method.
590 $a School code: 0099.
650 4 $a Chemistry, Analytical. $3 586156
650 4 $a Chemistry, Pharmaceutical. $3 550957
650 4 $a Chemistry, Biochemistry. $3 1017722
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710 2 0 $a The University of Kansas. $3 1288487
773 0 $t Dissertation Abstracts International $g 65-10B.
790 1 0 $a Lunte, Craig E., $e advisor
790 $a 0099
791 $a Ph.D.
792 $a 2004
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3150393