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Molecular variation and the evolutio...

Yi, Soojin.

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Molecular variation and the evolution of newly developing sex chromosomes of Drosophila miranda.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Molecular variation and the evolution of newly developing sex chromosomes of Drosophila miranda./
Author:	Yi, Soojin.
Description:	157 p.
Notes:	Source: Dissertation Abstracts International, Volume: 61-07, Section: B, page: 3401.
Contained By:	Dissertation Abstracts International61-07B.
Subject:	Biology, Genetics. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=9978091
ISBN:	0599843977

Molecular variation and the evolution of newly developing sex chromosomes of Drosophila miranda.
Yi, Soojin.

Molecular variation and the evolution of newly developing sex chromosomes of Drosophila miranda. - 157 p.

Source: Dissertation Abstracts International, Volume: 61-07, Section: B, page: 3401.

Thesis (Ph.D.)--The University of Chicago, 2000.

The species Drosophila miranda possesses a new set of sex chromsomes, called the neo-sex chromosomes. This has resulted from a unique chromosomal fusion between the Y chromosome and one of Muller's C element autosomal pair. Several pieces of evidence from previous cytogenetic and molecular investigations suggested that the neo-sex chromosomes of D. miranda are in their early stage of becoming fully differentiated sex chromosomes. I extended molecular analyses of these newly evolving sex chromosomes, focusing especially on the molecular variation of marker genes on the neo-sex chromosomes, in order to evaluate different theoretical explanations accounting for the differentiation of the sex chromosomes. It is shown in this dissertation that the genes on the neo-Y chromosome show a reduced level of DNA sequence variation compared to X-linked and autosomal genes. The genes on the neo-X chromosome investigated in this dissertation showed similarly reduced levels of variation. I discuss these findings in the context of different models of Y chromosome degeneration as well as the evolution of dosage compensation on the counterpart X chromosome. In addition I characterize several population genetic parameters of D. miranda to provide a framework to understand molecular variation of this species. One interesting phenomenon that emerged from this molecular dissection of D. miranda is that some genes appear to have transposed to different chromosomes from their ancestral locations. A selective hypothesis to account for this phenomenon in the context of the evolution of the neo-sex chromosomes is proposed and a detailed analysis of one case is carried out. Both genomic and population genetics approaches support the hypothesis that directional selection is responsible for the observed transposition of genes originally linked to the neo-sex chromosomes of D. miranda.

ISBN: 0599843977Subjects--Topical Terms:

1017730
Biology, Genetics.

Molecular variation and the evolution of newly developing sex chromosomes of Drosophila miranda.
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245 1 0 $a Molecular variation and the evolution of newly developing sex chromosomes of Drosophila miranda.
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500 $a Source: Dissertation Abstracts International, Volume: 61-07, Section: B, page: 3401.
500 $a Adviser: Manyuan Long.
502 $a Thesis (Ph.D.)--The University of Chicago, 2000.
520 $a The species Drosophila miranda possesses a new set of sex chromsomes, called the neo-sex chromosomes. This has resulted from a unique chromosomal fusion between the Y chromosome and one of Muller's C element autosomal pair. Several pieces of evidence from previous cytogenetic and molecular investigations suggested that the neo-sex chromosomes of D. miranda are in their early stage of becoming fully differentiated sex chromosomes. I extended molecular analyses of these newly evolving sex chromosomes, focusing especially on the molecular variation of marker genes on the neo-sex chromosomes, in order to evaluate different theoretical explanations accounting for the differentiation of the sex chromosomes. It is shown in this dissertation that the genes on the neo-Y chromosome show a reduced level of DNA sequence variation compared to X-linked and autosomal genes. The genes on the neo-X chromosome investigated in this dissertation showed similarly reduced levels of variation. I discuss these findings in the context of different models of Y chromosome degeneration as well as the evolution of dosage compensation on the counterpart X chromosome. In addition I characterize several population genetic parameters of D. miranda to provide a framework to understand molecular variation of this species. One interesting phenomenon that emerged from this molecular dissection of D. miranda is that some genes appear to have transposed to different chromosomes from their ancestral locations. A selective hypothesis to account for this phenomenon in the context of the evolution of the neo-sex chromosomes is proposed and a detailed analysis of one case is carried out. Both genomic and population genetics approaches support the hypothesis that directional selection is responsible for the observed transposition of genes originally linked to the neo-sex chromosomes of D. miranda.
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