東華大學圖書館 |

Language: English

Help

回圖書館首頁

手機版館藏查詢

Back

Switch To: Labeled | MARC Mode | ISBD

Genetic and biological differences a...

Chen, Woan-Ru Justin.

Linked to FindBook

Google Book

Amazon

博客來

Genetic and biological differences among Japanese encephalitis virus strains from various regions of Asia.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Genetic and biological differences among Japanese encephalitis virus strains from various regions of Asia./
Author:	Chen, Woan-Ru Justin.
Description:	134 p.
Notes:	Source: Dissertation Abstracts International, Volume: 54-01, Section: B, page: 0195.
Contained By:	Dissertation Abstracts International54-01B.
Subject:	Health Sciences, Public Health. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=9314796

Genetic and biological differences among Japanese encephalitis virus strains from various regions of Asia.
Chen, Woan-Ru Justin.

Genetic and biological differences among Japanese encephalitis virus strains from various regions of Asia. - 134 p.

Source: Dissertation Abstracts International, Volume: 54-01, Section: B, page: 0195.

Thesis (Ph.D.)--Yale University, 1992.

Fifty-eight strains of Japanese encephalitis (JE) virus from a variety of geographic areas in Asia were examined by primer-extension sequencing of the RNA templates. Two hundred-forty nucleotides from the C and pre-M gene regions were selected for study, since this region provided sufficient information for determining genetic relationships among the virus isolates. Using 12% divergence as a cutoff point for virus relationships, the 58 isolates fell into four distinct genotypic groups. One genotypic group consisted of JE virus isolates from northern Thailand and Cambodia. A second group was comprised of isolates from southern Thailand, Malaysia, Sarawak and Indonesia. Isolates from Japan, China, Taiwan, the Philippines, Sri Lanka, India and Nepal made up a third group. Several isolates from Indonesia formed a distinct fourth genotype. Strains belonging to the second and fourth genotypic groups were from areas where JE virus infection is common but encephalitis is rare. In contrast, strains from areas in which JE epidemics have occurred fell into the first and third genotypes. In an attempt to find biological virulence markers which might correlate with these genotypic variations, in vivo and in vitro systems were tested. Although individual differences among JE virus strains in plaque morphology and mouse virulence were found, no consistent biological patterns could be demonstrated among the various genotypes.Subjects--Topical Terms:

1017659
Health Sciences, Public Health.

Genetic and biological differences among Japanese encephalitis virus strains from various regions of Asia.
LDR:02312nmm 2200265 4500 001 1815522
005 20060710075121.5
008 130610s1992 eng d
035 $a (UnM)AAI9314796
035 $a AAI9314796
040 $a UnM $c UnM
100 1 $a Chen, Woan-Ru Justin. $3 1904942
245 1 0 $a Genetic and biological differences among Japanese encephalitis virus strains from various regions of Asia.
300 $a 134 p.
500 $a Source: Dissertation Abstracts International, Volume: 54-01, Section: B, page: 0195.
500 $a Adviser: Robert B. Tesh.
502 $a Thesis (Ph.D.)--Yale University, 1992.
520 $a Fifty-eight strains of Japanese encephalitis (JE) virus from a variety of geographic areas in Asia were examined by primer-extension sequencing of the RNA templates. Two hundred-forty nucleotides from the C and pre-M gene regions were selected for study, since this region provided sufficient information for determining genetic relationships among the virus isolates. Using 12% divergence as a cutoff point for virus relationships, the 58 isolates fell into four distinct genotypic groups. One genotypic group consisted of JE virus isolates from northern Thailand and Cambodia. A second group was comprised of isolates from southern Thailand, Malaysia, Sarawak and Indonesia. Isolates from Japan, China, Taiwan, the Philippines, Sri Lanka, India and Nepal made up a third group. Several isolates from Indonesia formed a distinct fourth genotype. Strains belonging to the second and fourth genotypic groups were from areas where JE virus infection is common but encephalitis is rare. In contrast, strains from areas in which JE epidemics have occurred fell into the first and third genotypes. In an attempt to find biological virulence markers which might correlate with these genotypic variations, in vivo and in vitro systems were tested. Although individual differences among JE virus strains in plaque morphology and mouse virulence were found, no consistent biological patterns could be demonstrated among the various genotypes.
590 $a School code: 0265.
650 4 $a Health Sciences, Public Health. $3 1017659
650 4 $a Biology, Microbiology. $3 1017734
690 $a 0573
690 $a 0410
710 2 0 $a Yale University. $3 515640
773 0 $t Dissertation Abstracts International $g 54-01B.
790 1 0 $a Tesh, Robert B., $e advisor
790 $a 0265
791 $a Ph.D.
792 $a 1992
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=9314796