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New approaches to and mechanistic st...

Kimmich, Barbara F. M.

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New approaches to and mechanistic studies of homogeneous asymmetric catalysis.

Record Type:	Electronic resources : Monograph/item
Title/Author:	New approaches to and mechanistic studies of homogeneous asymmetric catalysis./
Author:	Kimmich, Barbara F. M.
Description:	323 p.
Notes:	Source: Dissertation Abstracts International, Volume: 59-04, Section: B, page: 1644.
Contained By:	Dissertation Abstracts International59-04B.
Subject:	Chemistry, Inorganic. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=9813115
ISBN:	0591825929

New approaches to and mechanistic studies of homogeneous asymmetric catalysis.
Kimmich, Barbara F. M.

New approaches to and mechanistic studies of homogeneous asymmetric catalysis. - 323 p.

Source: Dissertation Abstracts International, Volume: 59-04, Section: B, page: 1644.

Thesis (Ph.D.)--The University of Wisconsin - Madison, 1998.

Although much is known about the activity and selectivity of chiral homogeneous catalysts, the optimal catalyst system and reaction conditions for a given substrate must still be empirically determined. Rational design of chiral catalysts remains a formidable task. The research described in this thesis has been directed towards gaining a more complete understanding of how selectivity is induced during catalytic reactions.

ISBN: 0591825929Subjects--Topical Terms:

517253
Chemistry, Inorganic.

New approaches to and mechanistic studies of homogeneous asymmetric catalysis.
LDR:03031nmm 2200289 4500 001 1813755
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020 $a 0591825929
035 $a (UnM)AAI9813115
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040 $a UnM $c UnM
100 1 $a Kimmich, Barbara F. M. $3 1903248
245 1 0 $a New approaches to and mechanistic studies of homogeneous asymmetric catalysis.
300 $a 323 p.
500 $a Source: Dissertation Abstracts International, Volume: 59-04, Section: B, page: 1644.
500 $a Supervisor: Clark R. Landis.
502 $a Thesis (Ph.D.)--The University of Wisconsin - Madison, 1998.
520 $a Although much is known about the activity and selectivity of chiral homogeneous catalysts, the optimal catalyst system and reaction conditions for a given substrate must still be empirically determined. Rational design of chiral catalysts remains a formidable task. The research described in this thesis has been directed towards gaining a more complete understanding of how selectivity is induced during catalytic reactions.
520 $a Direct investigation of catalytic systems can be difficult because the species which control reaction selectivity are often unstable. This thesis describes an attempt to model the turnover limiting and enantiodetermining step in the catalytic asymmetric hydrogenation of prochiral enamides by studying the oxidative addition of dihydrogen to a series of iridium bisolefin complexes. While the selectivities of the oxidative addition reactions do not directly correlate to those observed for the rhodium catalyzed asymmetric hydrogenation of prochiral enamides, these studies offer insight into the nature of H $\ sb2 $ activation and diastereomer exchange. A detailed study of one of the oxidative addition reactions is presented. The complex and somewhat surprising chemical behavior of the iridium dihydrides is discussed and a mechanism for diastereomer exchange is proposed.
520 $a This thesis also reports on the ongoing efforts towards rational catalyst design. The design, synthesis, and characterization of a class of novel boron-containing ferrocenyl ligands is described. These ligands are designed to induce selectivity in catalytic reactions via covalent or Lewis acid-base "secondary interactions," which occur outside the primary coordination sphere of the metal. A variety of ligand architectures have been prepared, and their structural characteristics are discussed in some detail. The crystal structures of metal complexes of these ligands are presented. The chemical reactivity of the ferrocene complexes is analyzed. Preliminary catalytic studies for one of the ligands yields promising selectivity for the rhodium catalyzed hydrogenation of a tris(allyl)borate (approx. 78% ee).
590 $a School code: 0262.
650 4 $a Chemistry, Inorganic. $3 517253
690 $a 0488
710 2 0 $a The University of Wisconsin - Madison. $3 626640
773 0 $t Dissertation Abstracts International $g 59-04B.
790 1 0 $a Landis, Clark R., $e advisor
790 $a 0262
791 $a Ph.D.
792 $a 1998
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=9813115