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Multiple cell signaling pathways and...

Yan, Shian-Jang.

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Multiple cell signaling pathways and a selector protein in Drosophila melanogaster wing development.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Multiple cell signaling pathways and a selector protein in Drosophila melanogaster wing development./
Author:	Yan, Shian-Jang.
Description:	156 p.
Notes:	Source: Dissertation Abstracts International, Volume: 65-12, Section: B, page: 6171.
Contained By:	Dissertation Abstracts International65-12B.
Subject:	Biology, Genetics. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3156840
ISBN:	0496176617

Multiple cell signaling pathways and a selector protein in Drosophila melanogaster wing development.
Yan, Shian-Jang.

Multiple cell signaling pathways and a selector protein in Drosophila melanogaster wing development. - 156 p.

Source: Dissertation Abstracts International, Volume: 65-12, Section: B, page: 6171.

Thesis (Ph.D.)--University of Rochester, 2005.

Drosophila wing development is a useful model for studying organogenesis, which requires input from cell signaling molecules and from selector genes that confer identity on various groups of cells. The focus of this thesis is on understanding how multiple signaling pathways, including Notch (N), Wingless (Wg), the EGF receptor (EGFR), Decapentaplegic (Dpp), and Apterous (Ap, a selector protein) control wing development.

ISBN: 0496176617Subjects--Topical Terms:

1017730
Biology, Genetics.

Multiple cell signaling pathways and a selector protein in Drosophila melanogaster wing development.
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100 1 $a Yan, Shian-Jang. $3 1902222
245 1 0 $a Multiple cell signaling pathways and a selector protein in Drosophila melanogaster wing development.
300 $a 156 p.
500 $a Source: Dissertation Abstracts International, Volume: 65-12, Section: B, page: 6171.
500 $a Co-Supervisors: Robert J. Fleming; Willis X. Li.
502 $a Thesis (Ph.D.)--University of Rochester, 2005.
520 $a Drosophila wing development is a useful model for studying organogenesis, which requires input from cell signaling molecules and from selector genes that confer identity on various groups of cells. The focus of this thesis is on understanding how multiple signaling pathways, including Notch (N), Wingless (Wg), the EGF receptor (EGFR), Decapentaplegic (Dpp), and Apterous (Ap, a selector protein) control wing development.
520 $a Our studies of a 794 bp cis-regulatory element of Serrate (Ser), an essential gene for wing development, demonstrate that Ap and the Notch and Wg pathways can sequentially control wing development through direct regulation of Ser expression in early, mid, and late third instar stages of larval development, respectively. In addition, Ser expression in the presumptive vein cells during pupal development is regulated by EGFR signaling. These results suggest that multiple signaling pathways and the activity of a selector protein are integrated by a cis-regulatory element, in a sequential manner, during Drosophila wing development.
520 $a We have also studied the molecular mechanisms by which signaling pathways control the progression and precision of vein cell differentiation during Drosophila pupal wing development. Using genetic mosaics, we have demonstrated that the Dpp and EGFR pathways upregulate each other's ligands, forming a positive-feedback signaling loop to promote the differentiation of provein cells. This Dpp-EGFR signaling loop activates the Notch pathway in neighboring intervein cells, where Notch signaling antagonizes the Dpp-EGFR loop via negative-feedback, thus confining the vein differentiation program to provein cells. We have also shown that the Dpp-EGFR signaling loop regulates Ser and Delta (Dl), which are required for vein differentiation, and activates the Notch pathway in provein cells as well. Moreover, our studies of the 794 bp Ser enhancer demonstrate that MAD and CREB, which are transcription factors downstream of Dpp and EGFR respectively, regulate Ser during vein cell differentiation, suggesting that the Dpp and EGFR pathways may converge on the enhancers of genes required for vein differentiation. These results suggest that a signaling network involving multiple pathways and operating through positive and negative feedback loops, progressively promotes cell differentiation and precisely controls the spatial separation of distinct cell types.
590 $a School code: 0188.
650 4 $a Biology, Genetics. $3 1017730
650 4 $a Biology, Cell. $3 1017686
650 4 $a Biology, Molecular. $3 1017719
690 $a 0369
690 $a 0379
690 $a 0307
710 2 0 $a University of Rochester. $3 515736
773 0 $t Dissertation Abstracts International $g 65-12B.
790 1 0 $a Fleming, Robert J., $e advisor
790 1 0 $a Li, Willis X., $e advisor
790 $a 0188
791 $a Ph.D.
792 $a 2005
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3156840