東華大學圖書館 |

Language: English

Help

回圖書館首頁

手機版館藏查詢

Back

Switch To: Labeled | MARC Mode | ISBD

Interleukin-17 signaling: Target ge...

Ruddy, Matthew J.

Linked to FindBook

Google Book

Amazon

博客來

Interleukin-17 signaling: Target genes and role in periodontal disease.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Interleukin-17 signaling: Target genes and role in periodontal disease./
Author:	Ruddy, Matthew J.
Description:	142 p.
Notes:	Source: Dissertation Abstracts International, Volume: 65-08, Section: B, page: 3939.
Contained By:	Dissertation Abstracts International65-08B.
Subject:	Health Sciences, Immunology. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3141311
ISBN:	0496884433

Interleukin-17 signaling: Target genes and role in periodontal disease.
Ruddy, Matthew J.

Interleukin-17 signaling: Target genes and role in periodontal disease. - 142 p.

Source: Dissertation Abstracts International, Volume: 65-08, Section: B, page: 3939.

Thesis (Ph.D.)--State University of New York at Buffalo, 2004.

IL-17 is the founding member of an emerging family of inflammatory cytokines whose functions remain poorly defined. This work describes two lines of investigation to determine the function of IL-17 in bone: in vitro using a cell culture system in a preosteoblast cell line, and in vivo using IL-17 receptor knockout mice.

ISBN: 0496884433Subjects--Topical Terms:

1017716
Health Sciences, Immunology.

Interleukin-17 signaling: Target genes and role in periodontal disease.
LDR:02990nmm 2200325 4500 001 1812346
005 20060424072429.5
008 130610s2004 eng d
020 $a 0496884433
035 $a (UnM)AAI3141311
035 $a AAI3141311
040 $a UnM $c UnM
100 1 $a Ruddy, Matthew J. $3 1901895
245 1 0 $a Interleukin-17 signaling: Target genes and role in periodontal disease.
300 $a 142 p.
500 $a Source: Dissertation Abstracts International, Volume: 65-08, Section: B, page: 3939.
500 $a Major Professor: Sarah L. Gaffen.
502 $a Thesis (Ph.D.)--State University of New York at Buffalo, 2004.
520 $a IL-17 is the founding member of an emerging family of inflammatory cytokines whose functions remain poorly defined. This work describes two lines of investigation to determine the function of IL-17 in bone: in vitro using a cell culture system in a preosteoblast cell line, and in vivo using IL-17 receptor knockout mice.
520 $a IL-17 amplifies inflammatory responses by triggering production of pro-inflammatory mediators including IL-6, IL-8, and TNFalpha. In the pre-osteoblast line MC3T3-E1, IL-17 synergizes potently with suboptimal doses of TNFalpha to produce IL-6. In investigating the molecular mechanism underlying synergy between TNFalpha and IL-17 signaling, we found that Affymetrix microarray experiments comparing genes induced by TNFalpha versus IL-17+TNFalpha revealed differential expression of the transcription factor C/EBPdelta. We then showed C/EBPdelta expression is at least partially responsible for mediating the synergistic production of IL-6. Another novel target gene identified in our microarray analysis was the LPS-inducible CXC chemokine LIX. We demonstrated that IL-17+TNFalpha resulted in a LIX specific induction of neutrophil migration, suggesting another molecular mechanism by which IL-17 modulates neutrophil trafficking and inflammation.
520 $a To examine the function of IL-17R signaling on bone metabolism in vivo, we used a model of infection-induced bone loss in IL-17R-/- mice. Specifically, mice infected with the periodontal pathogen P. gingivalis (Pg) experience bone loss in the alveolar bone crest of the jaw. As previously reported, our results indicate that both male and female wild type C57BL/6J mice were fairly resistant to P. gingivalis-induced alveolar bone loss. However, female mice deficient in the IL-17R are more susceptible to alveolar bone loss than their wild type counterparts following P. gingivalis infection. This suggests that the IL-17R acts predominantly in vivo to defend the host against periodontal infection and subsequent alveolar bone loss.
590 $a School code: 0656.
650 4 $a Health Sciences, Immunology. $3 1017716
650 4 $a Biology, Microbiology. $3 1017734
650 4 $a Health Sciences, Public Health. $3 1017659
650 4 $a Health Sciences, Dentistry. $3 1019378
690 $a 0982
690 $a 0410
690 $a 0573
690 $a 0567
710 2 0 $a State University of New York at Buffalo. $3 1017814
773 0 $t Dissertation Abstracts International $g 65-08B.
790 1 0 $a Gaffen, Sarah L., $e advisor
790 $a 0656
791 $a Ph.D.
792 $a 2004
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3141311