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The effect of zoledronic acid on an ...

Rieff, Joel Edward.

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The effect of zoledronic acid on an animal model of osteoarthritis.

Record Type:	Electronic resources : Monograph/item
Title/Author:	The effect of zoledronic acid on an animal model of osteoarthritis./
Author:	Rieff, Joel Edward.
Description:	61 p.
Notes:	Source: Masters Abstracts International, Volume: 40-05, page: 1180.
Contained By:	Masters Abstracts International40-05.
Subject:	Biology, Anatomy. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=1408411
ISBN:	0493581677

The effect of zoledronic acid on an animal model of osteoarthritis.
Rieff, Joel Edward.

The effect of zoledronic acid on an animal model of osteoarthritis. - 61 p.

Source: Masters Abstracts International, Volume: 40-05, page: 1180.

Thesis (M.S.)--Rush University, 2002.

Objective. To determine the effect of bone remodeling inhibition by zoledronic acid (ZA) on articular cartilage in a more naturally occurring model of Osteoarthritis (OA), employing anterior cruciate ligament transection (ACLT), in the rabbit knee joint.

ISBN: 0493581677Subjects--Topical Terms:

1021727
Biology, Anatomy.

The effect of zoledronic acid on an animal model of osteoarthritis.
LDR:01892nmm 2200313 4500 001 1811304
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008 130610s2002 eng d
020 $a 0493581677
035 $a (UnM)AAI1408411
035 $a AAI1408411
040 $a UnM $c UnM
100 1 $a Rieff, Joel Edward. $3 1900893
245 1 4 $a The effect of zoledronic acid on an animal model of osteoarthritis.
300 $a 61 p.
500 $a Source: Masters Abstracts International, Volume: 40-05, page: 1180.
500 $a Director: Carol Muehleman.
502 $a Thesis (M.S.)--Rush University, 2002.
520 $a Objective. To determine the effect of bone remodeling inhibition by zoledronic acid (ZA) on articular cartilage in a more naturally occurring model of Osteoarthritis (OA), employing anterior cruciate ligament transection (ACLT), in the rabbit knee joint.
520 $a Design. New Zealand White male rabbits were divided into four groups: (1) ACLT surgery; (2) ACLT surgery with subcutaneous ZA injections; (3) sham surgery with subcutaneous ZA injections; (4) sham surgery. Animals were sacrificed after 12-weeks.
520 $a Results. Tibial plateaus were the only articular surface displaying gross degeneration (2 of 25 animals) after ACLT surgery. Macroscopically, no significant differences were determined between the four groups. However, microscopic degeneration was observed in tissue of ACLT animals previously determined as macroscopically normal. A possible trend was determined between the four groups.
520 $a Conclusion. ZA demonstrated a potential trend toward a chondroprotective effect in a rabbit ACLT model of OA.
590 $a School code: 0821.
650 4 $a Biology, Anatomy. $3 1021727
650 4 $a Health Sciences, Pharmacology. $3 1017717
690 $a 0287
690 $a 0419
710 2 0 $a Rush University. $3 1261752
773 0 $t Masters Abstracts International $g 40-05.
790 1 0 $a Muehleman, Carol, $e advisor
790 $a 0821
791 $a M.S.
792 $a 2002
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=1408411