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Effects of low molecular weight glyc...

Walzer, Mark Alan.

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Effects of low molecular weight glycosaminoglycans in amyloid beta-induced models of Alzheimer's disease.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Effects of low molecular weight glycosaminoglycans in amyloid beta-induced models of Alzheimer's disease./
Author:	Walzer, Mark Alan.
Description:	156 p.
Notes:	Source: Dissertation Abstracts International, Volume: 64-08, Section: B, page: 3764.
Contained By:	Dissertation Abstracts International64-08B.
Subject:	Biology, Neuroscience. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3101655
ISBN:	0496492411

Effects of low molecular weight glycosaminoglycans in amyloid beta-induced models of Alzheimer's disease.
Walzer, Mark Alan.

Effects of low molecular weight glycosaminoglycans in amyloid beta-induced models of Alzheimer's disease. - 156 p.

Source: Dissertation Abstracts International, Volume: 64-08, Section: B, page: 3764.

Thesis (Ph.D.)--Loyola University Chicago, 2003.

Alzheimer's Disease (AD) is a progressive neurodegenerative disease mainly affecting the elderly population. Current treatment modalities alleviate the symptoms while not affecting the underlying causes of the disease. Future treatments are needed which prevent the underlying disease etiology. Amyloid beta (Abeta) deposited in the senile plaques is one of two neuropathological hallmarks of AD. Hyperphosphorylated and/or conformationally-altered tau protein forms neurofibrillary tangles (NFTs), which is the other neuropathological hallmark of AD. Previous research has shown a strong link between Abeta deposition and tau pathology, suggesting Abeta deposition may induce both neuropathological hallmarks. Subsequently, low molecular weight heparins have been shown to prevent Abeta deposition. However these studies did not investigate the subsequent effects of low molecular weight heparin treatment on tau pathology. Hence, this dissertation studied the treatment effects of low molecular weight heparins on Abeta-induced tau pathology using wild-type rat and transgenic tau mouse models, as well as cell culture and in vitro techniques. The results of this dissertation suggest low molecular weight heparin treatment may be beneficial in preventing the early neuropathology associated with AD.

ISBN: 0496492411Subjects--Topical Terms:

1017680
Biology, Neuroscience.

Effects of low molecular weight glycosaminoglycans in amyloid beta-induced models of Alzheimer's disease.
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100 1 $a Walzer, Mark Alan. $3 1900827
245 1 0 $a Effects of low molecular weight glycosaminoglycans in amyloid beta-induced models of Alzheimer's disease.
300 $a 156 p.
500 $a Source: Dissertation Abstracts International, Volume: 64-08, Section: B, page: 3764.
500 $a Director: John M. Lee.
502 $a Thesis (Ph.D.)--Loyola University Chicago, 2003.
520 $a Alzheimer's Disease (AD) is a progressive neurodegenerative disease mainly affecting the elderly population. Current treatment modalities alleviate the symptoms while not affecting the underlying causes of the disease. Future treatments are needed which prevent the underlying disease etiology. Amyloid beta (Abeta) deposited in the senile plaques is one of two neuropathological hallmarks of AD. Hyperphosphorylated and/or conformationally-altered tau protein forms neurofibrillary tangles (NFTs), which is the other neuropathological hallmark of AD. Previous research has shown a strong link between Abeta deposition and tau pathology, suggesting Abeta deposition may induce both neuropathological hallmarks. Subsequently, low molecular weight heparins have been shown to prevent Abeta deposition. However these studies did not investigate the subsequent effects of low molecular weight heparin treatment on tau pathology. Hence, this dissertation studied the treatment effects of low molecular weight heparins on Abeta-induced tau pathology using wild-type rat and transgenic tau mouse models, as well as cell culture and in vitro techniques. The results of this dissertation suggest low molecular weight heparin treatment may be beneficial in preventing the early neuropathology associated with AD.
590 $a School code: 0112.
650 4 $a Biology, Neuroscience. $3 1017680
650 4 $a Health Sciences, Pharmacology. $3 1017717
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710 2 0 $a Loyola University Chicago. $3 1020295
773 0 $t Dissertation Abstracts International $g 64-08B.
790 1 0 $a Lee, John M., $e advisor
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791 $a Ph.D.
792 $a 2003
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3101655