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The Deformability of Hypothermically...

Stadnick, Hart Peter Argyle.

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The Deformability of Hypothermically Stored Red Blood Cells.

Record Type:	Language materials, printed : Monograph/item
Title/Author:	The Deformability of Hypothermically Stored Red Blood Cells./
Author:	Stadnick, Hart Peter Argyle.
Description:	160 p.
Notes:	Source: Masters Abstracts International, Volume: 49-05, page: 3136.
Contained By:	Masters Abstracts International49-05.
Subject:	Health Sciences, Medicine and Surgery. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=MR73250
ISBN:	9780494732502

The Deformability of Hypothermically Stored Red Blood Cells.
Stadnick, Hart Peter Argyle.

The Deformability of Hypothermically Stored Red Blood Cells. - 160 p.

Source: Masters Abstracts International, Volume: 49-05, page: 3136.

Thesis (M.Sc.)--University of Alberta (Canada), 2011.

Transfusion medicine is dependent upon the ability to hypothermically preserve red blood cell (RBC) function ex vivo. Recent evidence suggests that the deformability of hypothermically stored RBCs may be compromised, potentially leading to microvasculature occlusion and tissue hypoxia in transfused patients. The main objectives of this thesis were to develop an ektacytometric technique suitable for detecting RBC deformability changes, establish whether deficits in RBC deformability due to hypothermic storage are occurring, and investigate liposomes as a biopreservation tool to modify the function of RBC membranes. This thesis demonstrates that hypothermic storage leads to RBC deformability impairments which can be detected by ektacytometry. In addition, this thesis has shown that the membrane characteristics and deformability of hypothermically stored RBCs can be differentially modified by treatment with liposomes of varying chemical composition. Through these investigations, this thesis has contributed to the advancement of the fields of transfusion medicine and biopreservation science.

ISBN: 9780494732502Subjects--Topical Terms:

1017756
Health Sciences, Medicine and Surgery.

The Deformability of Hypothermically Stored Red Blood Cells.
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020 $a 9780494732502
035 $a (UMI)AAIMR73250
035 $a AAIMR73250
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100 1 $a Stadnick, Hart Peter Argyle. $3 1685014
245 1 4 $a The Deformability of Hypothermically Stored Red Blood Cells.
300 $a 160 p.
500 $a Source: Masters Abstracts International, Volume: 49-05, page: 3136.
500 $a Advisers: Jelena Holovati; Jason Acker.
502 $a Thesis (M.Sc.)--University of Alberta (Canada), 2011.
520 $a Transfusion medicine is dependent upon the ability to hypothermically preserve red blood cell (RBC) function ex vivo. Recent evidence suggests that the deformability of hypothermically stored RBCs may be compromised, potentially leading to microvasculature occlusion and tissue hypoxia in transfused patients. The main objectives of this thesis were to develop an ektacytometric technique suitable for detecting RBC deformability changes, establish whether deficits in RBC deformability due to hypothermic storage are occurring, and investigate liposomes as a biopreservation tool to modify the function of RBC membranes. This thesis demonstrates that hypothermic storage leads to RBC deformability impairments which can be detected by ektacytometry. In addition, this thesis has shown that the membrane characteristics and deformability of hypothermically stored RBCs can be differentially modified by treatment with liposomes of varying chemical composition. Through these investigations, this thesis has contributed to the advancement of the fields of transfusion medicine and biopreservation science.
590 $a School code: 0351.
650 4 $a Health Sciences, Medicine and Surgery. $3 1017756
650 4 $a Health Sciences, Pathology. $3 1017854
690 $a 0564
690 $a 0571
710 2 $a University of Alberta (Canada). $3 626651
773 0 $t Masters Abstracts International $g 49-05.
790 1 0 $a Holovati, Jelena, $e advisor
790 1 0 $a Acker, Jason, $e advisor
790 $a 0351
791 $a M.Sc.
792 $a 2011
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=MR73250