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Novel therapies for NAFLD.

Nivala, Angela Marie.

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Novel therapies for NAFLD.

Record Type:	Language materials, printed : Monograph/item
Title/Author:	Novel therapies for NAFLD./
Author:	Nivala, Angela Marie.
Description:	148 p.
Notes:	Source: Dissertation Abstracts International, Volume: 72-08, Section: B, page: .
Contained By:	Dissertation Abstracts International72-08B.
Subject:	Chemistry, Biochemistry. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3454623
ISBN:	9781124644523

Novel therapies for NAFLD.
Nivala, Angela Marie.

Novel therapies for NAFLD. - 148 p.

Source: Dissertation Abstracts International, Volume: 72-08, Section: B, page: .

Thesis (Ph.D.)--Colorado State University, 2011.

Background/Aims. Non Alcoholic Fatty Liver Disease (NAFLD) is a chronic liver disease often associated with metabolic disorders like type 2 diabetes, cardiovascular disease, obesity, and metabolic syndrome. It is characterized by hepatic fat accumulation (steatosis) that is at or above 5% of liver weight in the absence of excessive alcohol consumption (< 20 g/day). Current treatment for NAFLD focuses on reducing body weight and improving insulin action. The intent of this thesis was to identify therapies that targeted the liver. In the first aim, we examined whether secretions from plant roots contained compounds that restricted lipid accumulation or improved insulin action. The second aim examined whether taurine could prevent characteristic features of disease progression. Specifically, we hypothesized that (1) onion root exudates will prevent or reduce lipid accumulation and improve insulin signaling and (2) taurine will prevent or reduce endoplasmic reticulum (ER) stress, oxidative stress and liver injury.

ISBN: 9781124644523Subjects--Topical Terms:

1017722
Chemistry, Biochemistry.

Novel therapies for NAFLD.
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020 $a 9781124644523
035 $a (UMI)AAI3454623
035 $a AAI3454623
040 $a UMI $c UMI
100 1 $a Nivala, Angela Marie. $3 1684935
245 1 0 $a Novel therapies for NAFLD.
300 $a 148 p.
500 $a Source: Dissertation Abstracts International, Volume: 72-08, Section: B, page: .
500 $a Adviser: Michael Pagliassotti.
502 $a Thesis (Ph.D.)--Colorado State University, 2011.
520 $a Background/Aims. Non Alcoholic Fatty Liver Disease (NAFLD) is a chronic liver disease often associated with metabolic disorders like type 2 diabetes, cardiovascular disease, obesity, and metabolic syndrome. It is characterized by hepatic fat accumulation (steatosis) that is at or above 5% of liver weight in the absence of excessive alcohol consumption (< 20 g/day). Current treatment for NAFLD focuses on reducing body weight and improving insulin action. The intent of this thesis was to identify therapies that targeted the liver. In the first aim, we examined whether secretions from plant roots contained compounds that restricted lipid accumulation or improved insulin action. The second aim examined whether taurine could prevent characteristic features of disease progression. Specifically, we hypothesized that (1) onion root exudates will prevent or reduce lipid accumulation and improve insulin signaling and (2) taurine will prevent or reduce endoplasmic reticulum (ER) stress, oxidative stress and liver injury.
520 $a Methods. To examine these hypotheses, liver cells and dietary models of NAFLD were employed. Analyses focused on hepatic triglycerides, insulin signaling, ER stress, oxidative stress and inflammation using basic biochemical methods such as western blotting, Real Time PCR, immunohistochemistry and enzyme-linked assays.
520 $a Results Onion root exudates prevented fatty acid-mediated lipid accumulation and enhanced insulin signaling in H4IIE liver cells. Onion root exudates reduced plasma glucose, free fatty acids (FFA), and improved insulin action in rats fed a high fat diet.
520 $a Taurine mitigated palmitate-mediated caspase-3 activity, cell death, ER stress, and oxidative stress in H4IIE liver cells and primary hepatocytes. In rats fed a high sucrose diet, taurine supplementation significantly reduced hepatic lipid accumulation, liver injury, inflammation, plasma triglycerides and insulin levels. The high sucrose diet resulted in an induction of multiple components of the unfolded protein response (UPR) in the liver consistent with ER stress which was ameliorated by taurine supplementation. Treatment of mice with the ER stress inducing agent tunicamycin resulted in liver injury, UPR induction and hepatic lipid accumulation, and this was significantly ameliorated by supplementation with taurine.
520 $a Conclusion. Both onion root exudates and taurine reduced metabolic abnormalities associated with NAFLD. Onion root exudates appear to exert this effect through reduced lipid accumulation and enhanced insulin sensitivity in the liver, while taurine reduced hepatic steatosis, ER stress, oxidative stress and liver injury. Overall, onion root exudates and taurine show promise as novel therapies for the treatment of NAFLD.
590 $a School code: 0053.
650 4 $a Chemistry, Biochemistry. $3 1017722
650 4 $a Health Sciences, Nutrition. $3 1017801
650 4 $a Biology, Physiology. $3 1017816
690 $a 0487
690 $a 0570
690 $a 0719
710 2 $a Colorado State University. $b Food Science & Human Nutrition. $3 1676397
773 0 $t Dissertation Abstracts International $g 72-08B.
790 1 0 $a Pagliassotti, Michael, $e advisor
790 1 0 $a Vivanco, Jorge $e committee member
790 1 0 $a Frye, Melinda $e committee member
790 1 0 $a Vanamala, Jairam $e committee member
790 $a 0053
791 $a Ph.D.
792 $a 2011
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3454623