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The role of liver in SIV pathogenesis.

Ahsan, Muhammad Haroon.

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The role of liver in SIV pathogenesis.

Record Type:	Language materials, printed : Monograph/item
Title/Author:	The role of liver in SIV pathogenesis./
Author:	Ahsan, Muhammad Haroon.
Description:	158 p.
Notes:	Source: Dissertation Abstracts International, Volume: 72-07, Section: B, page: .
Contained By:	Dissertation Abstracts International72-07B.
Subject:	Health Sciences, Pathology. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3454171
ISBN:	9781124630168

The role of liver in SIV pathogenesis.
Ahsan, Muhammad Haroon.

The role of liver in SIV pathogenesis. - 158 p.

Source: Dissertation Abstracts International, Volume: 72-07, Section: B, page: .

Thesis (Ph.D.)--Tulane University, 2011.

The macrophage is a common target cell for lentiviral infections, including HIV/ SIV. The kupffer cells of the liver are the largest population of resident macrophages in the body and efficiently filter microbial and other harmful products originate from the gut. An emerging feature of HIV/SIV pathogenesis is the increased levels of microbial translocation that leads to chronic immune activation, occur primarily in the later stages of infection. We used Rhesus macaques for our study as it the premier non-human primate model for the study of human immunodeficiency virus (HIV). We found that there is marked turnover of monocytes/macrophages in the liver consisting of increased rates of apoptosis balanced and surpassed by increased macrophage turn over, resulting in a net increase in Kupffer cells throughout SIV infection. Interestingly, SIV RNA In-situ hybridization in liver, detected only one positive animal. Furthermore, we detected large amount of LPS in the liver in acute SIVmac251 infection. We observed that the liver contain large numbers of T cells predominantly effector CD8+ T cells, both in uninfected and SIV-infected macaques. Furthermore, these data suggests that; (i) Kupffer cells in the liver are not supportive of high levels of viral replication in vivo; (ii) the liver effectively filters elevated levels of microbial products that enter the liver via the portal circulation during early SIV infection.

ISBN: 9781124630168Subjects--Topical Terms:

1017854
Health Sciences, Pathology.

The role of liver in SIV pathogenesis.
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100 1 $a Ahsan, Muhammad Haroon. $3 1684922
245 1 4 $a The role of liver in SIV pathogenesis.
300 $a 158 p.
500 $a Source: Dissertation Abstracts International, Volume: 72-07, Section: B, page: .
500 $a Adviser: Ronald S. Veazey.
502 $a Thesis (Ph.D.)--Tulane University, 2011.
520 $a The macrophage is a common target cell for lentiviral infections, including HIV/ SIV. The kupffer cells of the liver are the largest population of resident macrophages in the body and efficiently filter microbial and other harmful products originate from the gut. An emerging feature of HIV/SIV pathogenesis is the increased levels of microbial translocation that leads to chronic immune activation, occur primarily in the later stages of infection. We used Rhesus macaques for our study as it the premier non-human primate model for the study of human immunodeficiency virus (HIV). We found that there is marked turnover of monocytes/macrophages in the liver consisting of increased rates of apoptosis balanced and surpassed by increased macrophage turn over, resulting in a net increase in Kupffer cells throughout SIV infection. Interestingly, SIV RNA In-situ hybridization in liver, detected only one positive animal. Furthermore, we detected large amount of LPS in the liver in acute SIVmac251 infection. We observed that the liver contain large numbers of T cells predominantly effector CD8+ T cells, both in uninfected and SIV-infected macaques. Furthermore, these data suggests that; (i) Kupffer cells in the liver are not supportive of high levels of viral replication in vivo; (ii) the liver effectively filters elevated levels of microbial products that enter the liver via the portal circulation during early SIV infection.
590 $a School code: 0235.
650 4 $a Health Sciences, Pathology. $3 1017854
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710 2 $a Tulane University. $b Biomedical Sciences. $3 1025358
773 0 $t Dissertation Abstracts International $g 72-07B.
790 1 0 $a Veazey, Ronald S., $e advisor
790 1 0 $a Lackner, Andrew A. $e committee member
790 1 0 $a Garry, Robert F. $e committee member
790 1 0 $a Kaushal, Deepak $e committee member
790 $a 0235
791 $a Ph.D.
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856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3454171