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Separation of Alzheimer's disease bi...

Barry, Jeremy Alan.

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Separation of Alzheimer's disease biomarkers using a nanoparticle pseudostationary phase in capillary electrophoresis.

Record Type:	Language materials, printed : Monograph/item
Title/Author:	Separation of Alzheimer's disease biomarkers using a nanoparticle pseudostationary phase in capillary electrophoresis./
Author:	Barry, Jeremy Alan.
Description:	91 p.
Notes:	Source: Masters Abstracts International, Volume: 49-01, page: 0443.
Contained By:	Masters Abstracts International49-01.
Subject:	Chemistry, Analytical. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=1480170
ISBN:	9781124174983

Separation of Alzheimer's disease biomarkers using a nanoparticle pseudostationary phase in capillary electrophoresis.
Barry, Jeremy Alan.

Separation of Alzheimer's disease biomarkers using a nanoparticle pseudostationary phase in capillary electrophoresis. - 91 p.

Source: Masters Abstracts International, Volume: 49-01, page: 0443.

Thesis (M.S.)--The University of North Carolina at Greensboro, 2010.

Alzheimer's Disease (AD) is the most common form of senile dementia and affects millions of people worldwide. Patients with AD suffer from progressive memory loss that is caused by the loss of neurons and synapses in the portions of the brain responsible for memory and cognitive ability. AD is characterized by the formation of senile plaques made mostly of the Amyloid Beta peptide and neurofibrillary tangles consisting of the Tau protein. The onset of AD seems to be correlated with changes in the concentrations of the Amyloid Beta peptides and the Tau protein. The relative concentrations of Abeta 42 to Abeta40 and the total amount of Tau can be used as biomarkers for the early detection of AD. A fast, multianalyte analysis of these biomarkers could provide useful information in the diagnosis of the disease as well as a means of tracking disease progression. Capillary electrophoresis is a fast separations technique that allows for the separation of analyte based on the size to charge ratio. This technique coupled with laser-induced fluorescence is capable of picomolar limits of detection. This study focuses on a novel functionalized gold nanoparticle enhanced capillary electrophoresis technique for the separation and quantitation these Alzheimer's Disease biomarkers.

ISBN: 9781124174983Subjects--Topical Terms:

586156
Chemistry, Analytical.

Separation of Alzheimer's disease biomarkers using a nanoparticle pseudostationary phase in capillary electrophoresis.
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008 130515s2010 ||||||||||||||||| ||eng d
020 $a 9781124174983
035 $a (UMI)AAI1480170
035 $a AAI1480170
040 $a UMI $c UMI
100 1 $a Barry, Jeremy Alan. $3 1684132
245 1 0 $a Separation of Alzheimer's disease biomarkers using a nanoparticle pseudostationary phase in capillary electrophoresis.
300 $a 91 p.
500 $a Source: Masters Abstracts International, Volume: 49-01, page: 0443.
500 $a Adviser: Garry B. Dawson.
502 $a Thesis (M.S.)--The University of North Carolina at Greensboro, 2010.
520 $a Alzheimer's Disease (AD) is the most common form of senile dementia and affects millions of people worldwide. Patients with AD suffer from progressive memory loss that is caused by the loss of neurons and synapses in the portions of the brain responsible for memory and cognitive ability. AD is characterized by the formation of senile plaques made mostly of the Amyloid Beta peptide and neurofibrillary tangles consisting of the Tau protein. The onset of AD seems to be correlated with changes in the concentrations of the Amyloid Beta peptides and the Tau protein. The relative concentrations of Abeta 42 to Abeta40 and the total amount of Tau can be used as biomarkers for the early detection of AD. A fast, multianalyte analysis of these biomarkers could provide useful information in the diagnosis of the disease as well as a means of tracking disease progression. Capillary electrophoresis is a fast separations technique that allows for the separation of analyte based on the size to charge ratio. This technique coupled with laser-induced fluorescence is capable of picomolar limits of detection. This study focuses on a novel functionalized gold nanoparticle enhanced capillary electrophoresis technique for the separation and quantitation these Alzheimer's Disease biomarkers.
590 $a School code: 0154.
650 4 $a Chemistry, Analytical. $3 586156
690 $a 0486
710 2 $a The University of North Carolina at Greensboro. $b College of Arts & Sciences: Chemistry and Biochemistry. $3 1684133
773 0 $t Masters Abstracts International $g 49-01.
790 1 0 $a Dawson, Garry B., $e advisor
790 1 0 $a Chiu, Norman $e committee member
790 1 0 $a Reddick, Jason $e committee member
790 $a 0154
791 $a M.S.
792 $a 2010
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=1480170