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Trichostatin A and dihydrotestostero...

Yoo, Young-Eun.

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Trichostatin A and dihydrotestosterone as potential multi-systemic drugs for amyotrophic lateral sclerosis.

Record Type:	Language materials, printed : Monograph/item
Title/Author:	Trichostatin A and dihydrotestosterone as potential multi-systemic drugs for amyotrophic lateral sclerosis./
Author:	Yoo, Young-Eun.
Description:	129 p.
Notes:	Source: Dissertation Abstracts International, Volume: 71-06, Section: B, page: 3496.
Contained By:	Dissertation Abstracts International71-06B.
Subject:	Biology, Neurobiology. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3403667
ISBN:	9781109773323

Trichostatin A and dihydrotestosterone as potential multi-systemic drugs for amyotrophic lateral sclerosis.
Yoo, Young-Eun.

Trichostatin A and dihydrotestosterone as potential multi-systemic drugs for amyotrophic lateral sclerosis. - 129 p.

Source: Dissertation Abstracts International, Volume: 71-06, Section: B, page: 3496.

Thesis (Ph.D.)--University of Southern California, 2010.

Amyotrophic lateral sclerosis (ALS, also known as Lou Gehrig's disease) is a lethal neurodegenerative disease characterized by motor neuron loss, progressive muscle weakness, atrophy and paralysis. ALS is the most common motoneuron disease in human adults, and currently, there is no cure for ALS. Although ALS is a motoneuron disease, non-neuronal cells have been implicated in modulating motoneuron degeneration and disease progression. Because trichostatin A (TSA) and dihydrotestosterone (DHT) have shown beneficial effects on multiple cell types implicated in ALS, we examined their effects as a potential drug in a mouse model of ALS, SOD1 G93A mice.

ISBN: 9781109773323Subjects--Topical Terms:

1681328
Biology, Neurobiology.

Trichostatin A and dihydrotestosterone as potential multi-systemic drugs for amyotrophic lateral sclerosis.
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100 1 $a Yoo, Young-Eun. $3 1683872
245 1 0 $a Trichostatin A and dihydrotestosterone as potential multi-systemic drugs for amyotrophic lateral sclerosis.
300 $a 129 p.
500 $a Source: Dissertation Abstracts International, Volume: 71-06, Section: B, page: 3496.
500 $a Adviser: Chien-Ping Ko.
502 $a Thesis (Ph.D.)--University of Southern California, 2010.
520 $a Amyotrophic lateral sclerosis (ALS, also known as Lou Gehrig's disease) is a lethal neurodegenerative disease characterized by motor neuron loss, progressive muscle weakness, atrophy and paralysis. ALS is the most common motoneuron disease in human adults, and currently, there is no cure for ALS. Although ALS is a motoneuron disease, non-neuronal cells have been implicated in modulating motoneuron degeneration and disease progression. Because trichostatin A (TSA) and dihydrotestosterone (DHT) have shown beneficial effects on multiple cell types implicated in ALS, we examined their effects as a potential drug in a mouse model of ALS, SOD1 G93A mice.
520 $a The treatment of TSA or DHT to early symptomatic SOD1 G93A mice ameliorated muscle atrophy, NMJ denervation, axonal degeneration, and motoneuron death, which are the pathological characteristics found in SOD1 G93A mice. The improved morphology in TSA- or DHT-treated SOD1 G93A mice was accompanied by improved motor functions as well as prolonged lifespan. The beneficial effect exerted by TSA or DHT might be mediated by their potential effects on multiple cell types implicated in ALS. Since ALS is a disease that involves neuronal and non-neuronal cell types, TSA or DHT treatment, which can target multiple cell types, might be an effective strategy to slow motoneuron loss, as well as to improve motor performance that may lead to the improved quality of life for ALS patients.
590 $a School code: 0208.
650 4 $a Biology, Neurobiology. $3 1681328
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710 2 $a University of Southern California. $b Neuroscience. $3 1273735
773 0 $t Dissertation Abstracts International $g 71-06B.
790 1 0 $a Ko, Chien-Ping, $e advisor
790 1 0 $a Butler, Samantha J. $e committee member
790 1 0 $a Pike, Christian J. $e committee member
790 1 0 $a Youn, Jang H. $e committee member
790 $a 0208
791 $a Ph.D.
792 $a 2010
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