東華大學圖書館 |

Language: English

Help

回圖書館首頁

手機版館藏查詢

Back

Switch To: Labeled | MARC Mode | ISBD

Effects of membrane lateral organiza...

Zhu, Weiwei.

Linked to FindBook

Google Book

Amazon

博客來

Effects of membrane lateral organization on the anticancer activity of liposomal Ca4P against MCF-7 breast cancer cells.

Record Type:	Language materials, printed : Monograph/item
Title/Author:	Effects of membrane lateral organization on the anticancer activity of liposomal Ca4P against MCF-7 breast cancer cells./
Author:	Zhu, Weiwei.
Description:	88 p.
Notes:	Source: Masters Abstracts International, Volume: 48-06, page: 3680.
Contained By:	Masters Abstracts International48-06.
Subject:	Chemistry, Biochemistry. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=1479041
ISBN:	9781124105048

Effects of membrane lateral organization on the anticancer activity of liposomal Ca4P against MCF-7 breast cancer cells.
Zhu, Weiwei.

Effects of membrane lateral organization on the anticancer activity of liposomal Ca4P against MCF-7 breast cancer cells. - 88 p.

Source: Masters Abstracts International, Volume: 48-06, page: 3680.

Thesis (M.S.)--Temple University, 2010.

The goal of this research is to study how the cholesterol content in liposomal formulations affects the anticancer activity (e.g., cell growth suppression) of combretastatin A4 phosphate (CA4P). CA4P is a powerful antivascular agent currently under clinical trials for treating solid tumors. Liposomal CA4P has several advantages over free CA4P, including the reduced toxicities and the increased overall drug efficacy. In this thesis work, I have demonstrated that the proliferation of breast cancer MCF-7 cells varies with the cholesterol mole fraction in the formulation of liposomal CA4P in a biphasic manner, displaying a local minimum at the critical sterol mole fractions (Cr) for maximal superlattice formation. Cell proliferation was monitored using a fluorescence-based assay. Since cholesterol content determines membrane lateral organization, my results imply that membrane lateral organization plays an important role in regulating the anti-cancer activity of liposomal CA4P. This finding provides a new concept in the rational design of liposomal anti-cancer drugs. More than 20 anticancer drug formulations are in the market or under clinical trials. Most of them include cholesterol as a major component. My present study indicates that cholesterol is not just serving as a vesicle stabilizing agent, but also modulates the activity of liposomal drugs. The principle learned from CA4P can be extended to other liposomal anti-cancer drugs. This study is also significant from the membrane biophysics point of view. The data provide additional support for the sterol superlattice model and illustrate that the concept of sterol superlattice can be applied to biotechnology development.

ISBN: 9781124105048Subjects--Topical Terms:

1017722
Chemistry, Biochemistry.

Effects of membrane lateral organization on the anticancer activity of liposomal Ca4P against MCF-7 breast cancer cells.
LDR:02757nam 2200313 4500 001 1403365
005 20111115085222.5
008 130515s2010 ||||||||||||||||| ||eng d
020 $a 9781124105048
035 $a (UMI)AAI1479041
035 $a AAI1479041
040 $a UMI $c UMI
100 1 $a Zhu, Weiwei. $3 1682621
245 1 0 $a Effects of membrane lateral organization on the anticancer activity of liposomal Ca4P against MCF-7 breast cancer cells.
300 $a 88 p.
500 $a Source: Masters Abstracts International, Volume: 48-06, page: 3680.
500 $a Adviser: Parkson Lee-Gau Chong.
502 $a Thesis (M.S.)--Temple University, 2010.
520 $a The goal of this research is to study how the cholesterol content in liposomal formulations affects the anticancer activity (e.g., cell growth suppression) of combretastatin A4 phosphate (CA4P). CA4P is a powerful antivascular agent currently under clinical trials for treating solid tumors. Liposomal CA4P has several advantages over free CA4P, including the reduced toxicities and the increased overall drug efficacy. In this thesis work, I have demonstrated that the proliferation of breast cancer MCF-7 cells varies with the cholesterol mole fraction in the formulation of liposomal CA4P in a biphasic manner, displaying a local minimum at the critical sterol mole fractions (Cr) for maximal superlattice formation. Cell proliferation was monitored using a fluorescence-based assay. Since cholesterol content determines membrane lateral organization, my results imply that membrane lateral organization plays an important role in regulating the anti-cancer activity of liposomal CA4P. This finding provides a new concept in the rational design of liposomal anti-cancer drugs. More than 20 anticancer drug formulations are in the market or under clinical trials. Most of them include cholesterol as a major component. My present study indicates that cholesterol is not just serving as a vesicle stabilizing agent, but also modulates the activity of liposomal drugs. The principle learned from CA4P can be extended to other liposomal anti-cancer drugs. This study is also significant from the membrane biophysics point of view. The data provide additional support for the sterol superlattice model and illustrate that the concept of sterol superlattice can be applied to biotechnology development.
590 $a School code: 0225.
650 4 $a Chemistry, Biochemistry. $3 1017722
650 4 $a Health Sciences, Oncology. $3 1018566
690 $a 0487
690 $a 0992
710 2 $a Temple University. $b Biochemistry. $3 1669040
773 0 $t Masters Abstracts International $g 48-06.
790 1 0 $a Chong, Parkson Lee-Gau, $e advisor
790 1 0 $a Collins, Jimmy $e committee member
790 1 0 $a Merali, Salim $e committee member
790 1 0 $a Chan, Marrion $e committee member
790 $a 0225
791 $a M.S.
792 $a 2010
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=1479041