東華大學圖書館 |

Language: English

Help

回圖書館首頁

手機版館藏查詢

Back

Switch To: Labeled | MARC Mode | ISBD

Systems modeling of the oral metabiome.

Brown, Robert E.

Linked to FindBook

Google Book

Amazon

博客來

Systems modeling of the oral metabiome.

Record Type:	Language materials, printed : Monograph/item
Title/Author:	Systems modeling of the oral metabiome./
Author:	Brown, Robert E.
Description:	134 p.
Notes:	Source: Dissertation Abstracts International, Volume: 72-07, Section: B, page: .
Contained By:	Dissertation Abstracts International72-07B.
Subject:	Biology, Systematic. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3455043
ISBN:	9781124617282

Systems modeling of the oral metabiome.
Brown, Robert E.

Systems modeling of the oral metabiome. - 134 p.

Source: Dissertation Abstracts International, Volume: 72-07, Section: B, page: .

Thesis (Ph.D.)--George Mason University, 2011.

Deciphering the underlying biological processes comprising the Human Oral Metabiome is important to the understanding of Human Immunodeficiency Virus (HIV) disease. The National Institute of Health has launched the Human Microbiome Project (HMP) to accelerate research and discovery techniques for five microbiome sites on the human body. Knowledge discovery techniques are needed to point researchers to follow-on hypotheses to quickly pinpoint areas of great promise. We developed the Differential Correlation Network (DCN) as a technique for researcher's to perform knowledge discovery in the oral mycobiome field. Using data from the Oral Microbiome, Differential Correlation Networks were applied to metabolites, bacteria, and fungi sampled from 12 Controls and 12 HIV Patients. By analyzing 100's of features across disease vs. control classes, statistically significant feature pair differences are captured and presented in Cytoscape. Several interesting differences are discovered and their possible biological significance is presented. The Systems model in conjunction with known biological metadata can identify promising difference networks and direct follow-on research based on DCN generated hypothesis.

ISBN: 9781124617282Subjects--Topical Terms:

1676856
Biology, Systematic.

Systems modeling of the oral metabiome.
LDR:02074nam 2200277 4500 001 1403069
005 20111108080409.5
008 130515s2011 ||||||||||||||||| ||eng d
020 $a 9781124617282
035 $a (UMI)AAI3455043
035 $a AAI3455043
040 $a UMI $c UMI
100 1 $a Brown, Robert E. $3 675660
245 1 0 $a Systems modeling of the oral metabiome.
300 $a 134 p.
500 $a Source: Dissertation Abstracts International, Volume: 72-07, Section: B, page: .
500 $a Adviser: Patrick M. Gillevet.
502 $a Thesis (Ph.D.)--George Mason University, 2011.
520 $a Deciphering the underlying biological processes comprising the Human Oral Metabiome is important to the understanding of Human Immunodeficiency Virus (HIV) disease. The National Institute of Health has launched the Human Microbiome Project (HMP) to accelerate research and discovery techniques for five microbiome sites on the human body. Knowledge discovery techniques are needed to point researchers to follow-on hypotheses to quickly pinpoint areas of great promise. We developed the Differential Correlation Network (DCN) as a technique for researcher's to perform knowledge discovery in the oral mycobiome field. Using data from the Oral Microbiome, Differential Correlation Networks were applied to metabolites, bacteria, and fungi sampled from 12 Controls and 12 HIV Patients. By analyzing 100's of features across disease vs. control classes, statistically significant feature pair differences are captured and presented in Cytoscape. Several interesting differences are discovered and their possible biological significance is presented. The Systems model in conjunction with known biological metadata can identify promising difference networks and direct follow-on research based on DCN generated hypothesis.
590 $a School code: 0883.
650 4 $a Biology, Systematic. $3 1676856
650 4 $a Biology, Bioinformatics. $3 1018415
690 $a 0423
690 $a 0715
710 2 $a George Mason University. $3 1019450
773 0 $t Dissertation Abstracts International $g 72-07B.
790 1 0 $a Gillevet, Patrick M., $e advisor
790 $a 0883
791 $a Ph.D.
792 $a 2011
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3455043