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Development of novel physical method...

Jenista, Elizabeth Rose.

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Development of novel physical methods to enhance contrast and sensitivity in magnetic resonance imaging.

Record Type:	Language materials, printed : Monograph/item
Title/Author:	Development of novel physical methods to enhance contrast and sensitivity in magnetic resonance imaging./
Author:	Jenista, Elizabeth Rose.
Description:	239 p.
Notes:	Source: Dissertation Abstracts International, Volume: 71-09, Section: B, page: 5488.
Contained By:	Dissertation Abstracts International71-09B.
Subject:	Chemistry, Physical. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3413857
ISBN:	9781124154404

Development of novel physical methods to enhance contrast and sensitivity in magnetic resonance imaging.
Jenista, Elizabeth Rose.

Development of novel physical methods to enhance contrast and sensitivity in magnetic resonance imaging. - 239 p.

Source: Dissertation Abstracts International, Volume: 71-09, Section: B, page: 5488.

Thesis (Ph.D.)--Duke University, 2010.

The purpose of this thesis is to report technological developments in contrast mechanisms for MRI. The search for new forms of contrast is on-going, with the hope that new contrast mechanisms and new contrast agents will provide new and unique insight into various molecular processes and disease states. In this dissertation, we will describe new contrast mechanisms developed by manipulating the inherent physics of the system, as well as the development of exogenous contrast agents. More specifically, we will describe the application of iMQCs (intermolecular multiple quantum coherences) to thermometry and structural imaging, and the unique information provided from these studies. We will also describe methods for migrating iMQC-based pulse sequences from a Bruker research console onto a clinical GE console, thus enabling the application of iMQCs to humans. We will describe the development of hyperpolarized contrast agents which have the potential to provide an unprecedented level of molecular contrast to MRI and the development of techniques to enhance the lifetime of these hyperpolarized contrast agents. Finally, we will discuss a new type of T2-weighted imaging which significantly improves the refocusing of CPMG-type sequences.

ISBN: 9781124154404Subjects--Topical Terms:

560527
Chemistry, Physical.

Development of novel physical methods to enhance contrast and sensitivity in magnetic resonance imaging.
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035 $a (UMI)AAI3413857
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100 1 $a Jenista, Elizabeth Rose. $3 1680573
245 1 0 $a Development of novel physical methods to enhance contrast and sensitivity in magnetic resonance imaging.
300 $a 239 p.
500 $a Source: Dissertation Abstracts International, Volume: 71-09, Section: B, page: 5488.
500 $a Adviser: Warren S. Warren.
502 $a Thesis (Ph.D.)--Duke University, 2010.
520 $a The purpose of this thesis is to report technological developments in contrast mechanisms for MRI. The search for new forms of contrast is on-going, with the hope that new contrast mechanisms and new contrast agents will provide new and unique insight into various molecular processes and disease states. In this dissertation, we will describe new contrast mechanisms developed by manipulating the inherent physics of the system, as well as the development of exogenous contrast agents. More specifically, we will describe the application of iMQCs (intermolecular multiple quantum coherences) to thermometry and structural imaging, and the unique information provided from these studies. We will also describe methods for migrating iMQC-based pulse sequences from a Bruker research console onto a clinical GE console, thus enabling the application of iMQCs to humans. We will describe the development of hyperpolarized contrast agents which have the potential to provide an unprecedented level of molecular contrast to MRI and the development of techniques to enhance the lifetime of these hyperpolarized contrast agents. Finally, we will discuss a new type of T2-weighted imaging which significantly improves the refocusing of CPMG-type sequences.
590 $a School code: 0066.
650 4 $a Chemistry, Physical. $3 560527
650 4 $a Health Sciences, Radiology. $3 1019076
690 $a 0494
690 $a 0574
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773 0 $t Dissertation Abstracts International $g 71-09B.
790 1 0 $a Warren, Warren S., $e advisor
790 1 0 $a Spicer, Leonard $e committee member
790 1 0 $a Toone, Eric $e committee member
790 1 0 $a Shaw, Barbra $e committee member
790 $a 0066
791 $a Ph.D.
792 $a 2010
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3413857