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Mechanical characterization of silk-...

Kluge, Jonathan A.

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Mechanical characterization of silk-based biomaterials for functional tissue engineering.

Record Type:	Language materials, printed : Monograph/item
Title/Author:	Mechanical characterization of silk-based biomaterials for functional tissue engineering./
Author:	Kluge, Jonathan A.
Description:	174 p.
Notes:	Source: Dissertation Abstracts International, Volume: 71-06, Section: B, page: 3793.
Contained By:	Dissertation Abstracts International71-06B.
Subject:	Engineering, Biomedical. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3403334
ISBN:	9781109767988

Mechanical characterization of silk-based biomaterials for functional tissue engineering.
Kluge, Jonathan A.

Mechanical characterization of silk-based biomaterials for functional tissue engineering. - 174 p.

Source: Dissertation Abstracts International, Volume: 71-06, Section: B, page: 3793.

Thesis (Ph.D.)--Tufts University, 2010.

It has proven extremely difficult to bioengineer functionally-equivalent tissue implants and models, no less predict how these functional properties will change in response to the body's loads. Therefore, in order to advance their clinical relevance, especially in musculoskeletal applications, it is essential that researchers focus more directly on the functionality of tissue implants, understand more clearly the core mechanisms behind successful design, and develop systems through which we can compare our models against the designs of nature. Consistent with these needs, our aim was to significantly advance our use of specific biomaterials towards a range of applications by establishing several mechanical testing strategies for preclinical evaluation. In the first set of studies, we describe the design of a novel hydrogel system and a series of compression testing analyses to understand the capacity of the hydrogels to sustain physiological loads as a function of protein concentration. From these experiments, a deformation mechanism based on poroelasticity was applied and several compression-dependent properties were established. In the second set of studies, we describe the design of an experimental platform to enable concurrent mechanical stimulation and data collection and non-invasive imaging techniques. The bioreactor demonstrates a wide applicability for constructs of different polymer types, sizes, and geometries, as well as exploiting a breadth of noninvasive markers specific to developing tissue or the underlying tissue scaffolds. Thereafter, we apply this design for the specific case of fibers undergoing cyclic loading and enzymatic attack as a physiologically-relevant model for biomaterial remodeling. All of these topics are explored within the context of silk-based biomaterials, but the lessons learned are nevertheless conceptually application to a wide range of degradable biomaterials. In conclusion, these new evaluation strategies provide promising new avenues of research to study functional tissue engineering paradigms, with a more clear connection to their microstructural content, and to further refine clinical repair strategies.

ISBN: 9781109767988Subjects--Topical Terms:

1017684
Engineering, Biomedical.

Mechanical characterization of silk-based biomaterials for functional tissue engineering.
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035 $a (UMI)AAI3403334
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100 1 $a Kluge, Jonathan A. $3 1679893
245 1 0 $a Mechanical characterization of silk-based biomaterials for functional tissue engineering.
300 $a 174 p.
500 $a Source: Dissertation Abstracts International, Volume: 71-06, Section: B, page: 3793.
500 $a Advisers: David L. Kaplan; Luis A. Dorfmann.
502 $a Thesis (Ph.D.)--Tufts University, 2010.
520 $a It has proven extremely difficult to bioengineer functionally-equivalent tissue implants and models, no less predict how these functional properties will change in response to the body's loads. Therefore, in order to advance their clinical relevance, especially in musculoskeletal applications, it is essential that researchers focus more directly on the functionality of tissue implants, understand more clearly the core mechanisms behind successful design, and develop systems through which we can compare our models against the designs of nature. Consistent with these needs, our aim was to significantly advance our use of specific biomaterials towards a range of applications by establishing several mechanical testing strategies for preclinical evaluation. In the first set of studies, we describe the design of a novel hydrogel system and a series of compression testing analyses to understand the capacity of the hydrogels to sustain physiological loads as a function of protein concentration. From these experiments, a deformation mechanism based on poroelasticity was applied and several compression-dependent properties were established. In the second set of studies, we describe the design of an experimental platform to enable concurrent mechanical stimulation and data collection and non-invasive imaging techniques. The bioreactor demonstrates a wide applicability for constructs of different polymer types, sizes, and geometries, as well as exploiting a breadth of noninvasive markers specific to developing tissue or the underlying tissue scaffolds. Thereafter, we apply this design for the specific case of fibers undergoing cyclic loading and enzymatic attack as a physiologically-relevant model for biomaterial remodeling. All of these topics are explored within the context of silk-based biomaterials, but the lessons learned are nevertheless conceptually application to a wide range of degradable biomaterials. In conclusion, these new evaluation strategies provide promising new avenues of research to study functional tissue engineering paradigms, with a more clear connection to their microstructural content, and to further refine clinical repair strategies.
590 $a School code: 0234.
650 4 $a Engineering, Biomedical. $3 1017684
650 4 $a Engineering, Mechanical. $3 783786
650 4 $a Biophysics, Biomechanics. $3 1035342
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690 $a 0548
690 $a 0648
710 2 $a Tufts University. $b Biomedical Engineering. $3 1023780
773 0 $t Dissertation Abstracts International $g 71-06B.
790 1 0 $a Kaplan, David L., $e advisor
790 1 0 $a Dorfmann, Luis A., $e advisor
790 1 0 $a Omenetto, Fiorenzo G. $e committee member
790 1 0 $a Wong, Joyce Y. $e committee member
790 $a 0234
791 $a Ph.D.
792 $a 2010
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3403334