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Involvement of the Polyamine System ...

Fiori, Laura Marie.

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Involvement of the Polyamine System in Suicide.

Record Type:	Language materials, printed : Monograph/item
Title/Author:	Involvement of the Polyamine System in Suicide./
Author:	Fiori, Laura Marie.
Description:	305 p.
Notes:	Source: Dissertation Abstracts International, Volume: 72-07, Section: B, page: .
Contained By:	Dissertation Abstracts International72-07B.
Subject:	Biology, Neuroscience. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=NR72628
ISBN:	9780494726280

Involvement of the Polyamine System in Suicide.
Fiori, Laura Marie.

Involvement of the Polyamine System in Suicide. - 305 p.

Source: Dissertation Abstracts International, Volume: 72-07, Section: B, page: .

Thesis (Ph.D.)--McGill University (Canada), 2010.

The polyamine system plays an essential role in a myriad of cellular functions, and dysregulated polyamine metabolism and functioning has been implicated in a number of pathological conditions, including neurological and psychiatric disorders. In recent years, gene expression and genetic association studies have provided strong evidence implicating the polyamine system in suicide, yet it was unclear how extensively polyamine metabolism is affected across the brains of suicide completers, if similar mechanisms are involved in other psychiatric conditions, nor the molecular events by which these alterations in gene expression arise. The studies comprising this thesis were thus designed to address these issues, as they represent essential considerations both for interpreting previous findings regarding the polyamine system, as well as for evaluating the potential for this system to be used as a therapeutic target for the treatment of suicidal behaviors. To address these issues, a combination of gene expression and genetic association studies were first performed in order to better characterize the extent by which polyamine metabolism is affected across the brains of suicide completers, to determine if similar mechanisms are implicated in other psychiatric conditions, and to assess how the altered expression of these genes is related to the local genetic environment. Following these studies, a series of experiments were performed to investigate the involvement of genetic and epigenetic mechanisms in determining the expression of polyamine genes in the brain, as well as to evaluate the association of these factors with suicide. Collectively, the studies contained herein have not only replicated previous findings implicating the polyamine system in suicide, but have also greatly expanded our knowledge regarding the extent by which this system is affected in suicide, and have extended these findings towards other psychiatric conditions. In addition, several genetic and epigenetic mechanisms were identified which account, in part, for alterations in polyamine gene expression that occur in suicide. Ultimately, these findings have established that the polyamine system represents an important facet of the neurobiological alterations that occur in suicide, and have provided insight into the means by which this system is involved in the etiology and pathology of suicidal behaviors.

ISBN: 9780494726280Subjects--Topical Terms:

1017680
Biology, Neuroscience.

Involvement of the Polyamine System in Suicide.
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245 1 0 $a Involvement of the Polyamine System in Suicide.
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500 $a Source: Dissertation Abstracts International, Volume: 72-07, Section: B, page: .
502 $a Thesis (Ph.D.)--McGill University (Canada), 2010.
520 $a The polyamine system plays an essential role in a myriad of cellular functions, and dysregulated polyamine metabolism and functioning has been implicated in a number of pathological conditions, including neurological and psychiatric disorders. In recent years, gene expression and genetic association studies have provided strong evidence implicating the polyamine system in suicide, yet it was unclear how extensively polyamine metabolism is affected across the brains of suicide completers, if similar mechanisms are involved in other psychiatric conditions, nor the molecular events by which these alterations in gene expression arise. The studies comprising this thesis were thus designed to address these issues, as they represent essential considerations both for interpreting previous findings regarding the polyamine system, as well as for evaluating the potential for this system to be used as a therapeutic target for the treatment of suicidal behaviors. To address these issues, a combination of gene expression and genetic association studies were first performed in order to better characterize the extent by which polyamine metabolism is affected across the brains of suicide completers, to determine if similar mechanisms are implicated in other psychiatric conditions, and to assess how the altered expression of these genes is related to the local genetic environment. Following these studies, a series of experiments were performed to investigate the involvement of genetic and epigenetic mechanisms in determining the expression of polyamine genes in the brain, as well as to evaluate the association of these factors with suicide. Collectively, the studies contained herein have not only replicated previous findings implicating the polyamine system in suicide, but have also greatly expanded our knowledge regarding the extent by which this system is affected in suicide, and have extended these findings towards other psychiatric conditions. In addition, several genetic and epigenetic mechanisms were identified which account, in part, for alterations in polyamine gene expression that occur in suicide. Ultimately, these findings have established that the polyamine system represents an important facet of the neurobiological alterations that occur in suicide, and have provided insight into the means by which this system is involved in the etiology and pathology of suicidal behaviors.
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