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Illuminating biomolecular interactio...

Mayer, Kathryn M.

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Illuminating biomolecular interactions with localized surface plasmon resonance.

Record Type:	Language materials, printed : Monograph/item
Title/Author:	Illuminating biomolecular interactions with localized surface plasmon resonance./
Author:	Mayer, Kathryn M.
Description:	97 p.
Notes:	Source: Dissertation Abstracts International, Volume: 71-09, Section: B, page: 5546.
Contained By:	Dissertation Abstracts International71-09B.
Subject:	Chemistry, Physical. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3421409
ISBN:	9781124203874

Illuminating biomolecular interactions with localized surface plasmon resonance.
Mayer, Kathryn M.

Illuminating biomolecular interactions with localized surface plasmon resonance. - 97 p.

Source: Dissertation Abstracts International, Volume: 71-09, Section: B, page: 5546.

Thesis (Ph.D.)--Rice University, 2010.

Noble metal nanoparticles exhibit localized surface plasmon resonance (LSPR), in which incident light causes a collective oscillation of a nanoparticle's free electrons. This phenomenon results in unique optical properties, including enhanced electric fields near the particle surface and an extinction peak at the resonant wavelength. The LSPR extinction peak's location is sensitive to the refractive index of the surrounding medium, especially in the volume closest to the particle surface. This makes plasmonic nanoparticles ideal for biosensing: their refractive index sensitivity can be used to transduce molecular binding signals. A method has been developed to use the optical extinction of films of gold nanorods to track antibody-antigen interactions in real time, resulting in a label-free kinetic immunoassay based on LSPR. Also, this method has been adapted to scattering spectra of single gold bipyramids. The single-particle approach has allowed the label-free detection of single biomolecules with kinetics information. These methods have future applications to both molecular biology and clinical assays.

ISBN: 9781124203874Subjects--Topical Terms:

560527
Chemistry, Physical.

Illuminating biomolecular interactions with localized surface plasmon resonance.
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035 $a (UMI)AAI3421409
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100 1 $a Mayer, Kathryn M. $3 1678232
245 1 0 $a Illuminating biomolecular interactions with localized surface plasmon resonance.
300 $a 97 p.
500 $a Source: Dissertation Abstracts International, Volume: 71-09, Section: B, page: 5546.
500 $a Adviser: Jason Hafher.
502 $a Thesis (Ph.D.)--Rice University, 2010.
520 $a Noble metal nanoparticles exhibit localized surface plasmon resonance (LSPR), in which incident light causes a collective oscillation of a nanoparticle's free electrons. This phenomenon results in unique optical properties, including enhanced electric fields near the particle surface and an extinction peak at the resonant wavelength. The LSPR extinction peak's location is sensitive to the refractive index of the surrounding medium, especially in the volume closest to the particle surface. This makes plasmonic nanoparticles ideal for biosensing: their refractive index sensitivity can be used to transduce molecular binding signals. A method has been developed to use the optical extinction of films of gold nanorods to track antibody-antigen interactions in real time, resulting in a label-free kinetic immunoassay based on LSPR. Also, this method has been adapted to scattering spectra of single gold bipyramids. The single-particle approach has allowed the label-free detection of single biomolecules with kinetics information. These methods have future applications to both molecular biology and clinical assays.
590 $a School code: 0187.
650 4 $a Chemistry, Physical. $3 560527
650 4 $a Nanoscience. $3 587832
650 4 $a Physics, Optics. $3 1018756
650 4 $a Biophysics, General. $3 1019105
690 $a 0494
690 $a 0565
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710 2 $a Rice University. $3 960124
773 0 $t Dissertation Abstracts International $g 71-09B.
790 1 0 $a Hafher, Jason, $e advisor
790 $a 0187
791 $a Ph.D.
792 $a 2010
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3421409