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Rheology and structure of thermoreve...

Jiang, Jun.

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Rheology and structure of thermoreversible hydrogels.

Record Type:	Language materials, printed : Monograph/item
Title/Author:	Rheology and structure of thermoreversible hydrogels./
Author:	Jiang, Jun.
Description:	112 p.
Notes:	Source: Dissertation Abstracts International, Volume: 69-10, Section: B, page: 6351.
Contained By:	Dissertation Abstracts International69-10B.
Subject:	Engineering, Materials Science. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3334909
ISBN:	9780549882046

Rheology and structure of thermoreversible hydrogels.
Jiang, Jun.

Rheology and structure of thermoreversible hydrogels. - 112 p.

Source: Dissertation Abstracts International, Volume: 69-10, Section: B, page: 6351.

Thesis (Ph.D.)--State University of New York at Stony Brook, 2007.

Highly concentrated solutions of non-ionic amphiphilic triblock copolymer poly(ethylene oxide)99-poly(propylene oxide)67-poly(ethylene oxide)99 (Pluronic F127) are widely used in numerous biomedical applications, such as drug delivery vehicles, and surfactants for emulsification of food and personal care products. The Pluronic copolymers are popular for these applications, since their gelation properties are thermoreversible and easily controlled by varying the concentration. They are liquid below room temperature and gel at body temperature. Hence they are great injectable biomaterials for tissue engineering and implantation.

ISBN: 9780549882046Subjects--Topical Terms:

1017759
Engineering, Materials Science.

Rheology and structure of thermoreversible hydrogels.
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020 $a 9780549882046
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100 1 $a Jiang, Jun. $3 1678184
245 1 0 $a Rheology and structure of thermoreversible hydrogels.
300 $a 112 p.
500 $a Source: Dissertation Abstracts International, Volume: 69-10, Section: B, page: 6351.
502 $a Thesis (Ph.D.)--State University of New York at Stony Brook, 2007.
520 $a Highly concentrated solutions of non-ionic amphiphilic triblock copolymer poly(ethylene oxide)99-poly(propylene oxide)67-poly(ethylene oxide)99 (Pluronic F127) are widely used in numerous biomedical applications, such as drug delivery vehicles, and surfactants for emulsification of food and personal care products. The Pluronic copolymers are popular for these applications, since their gelation properties are thermoreversible and easily controlled by varying the concentration. They are liquid below room temperature and gel at body temperature. Hence they are great injectable biomaterials for tissue engineering and implantation.
520 $a In this dissertation, thermal gelation and structure of high concentration triblock copolymer Pluronic F127-clay (Cloisite Na+ and Lucentite SWN) aqueous solutions were characterized by rheological measurements, differential scanning calorimetry (DSC) and small angle X-ray/neutron scattering. Small angle neutron scattering (SANS), under shear using a Couette cell in radial and tangential scattering geometry, was performed to examine the structural evolution of the polymeric micellar macro-lattice formed by concentrated aqueous solutions of triblock copolymer-Pluronic F127, as a function of the shear rate. The micellar gel showed a shear thinning, i.e., a reduction of the resistance to shear, by forming a layered stacking of two-dimensional hexagonally close packed (HCP) polymer micelles. A theoretical model was developed to calculate 2D SANS scattering patterns that can be compared with the experimental data.
520 $a In order to improve the mechanical properties of the gel, while still maintaining the thermo-reversibility, we synthesized multiblock structures, where the F127 construct would be repeated several times. In this manner, physical interconnections between the micelles could occur as the multiblock copolymers formed interlocking loops and tails, thereby greatly increasing the mechanical strength of the gels. The rheological and structural properties of the gels were characterized as a function of temperature, composition and degree of polymerization. For F127 solutions just below their gel point, substitution of F127 with as little as 1% multiblock succeeded in forming a physical gel. Percolation theory was used to understand the modulus growth when multiblock was added to F127 solutions just below their gel point, assuming the multiblocks form bridges between adjacent micelles.
590 $a School code: 0771.
650 4 $a Engineering, Materials Science. $3 1017759
690 $a 0794
710 2 $a State University of New York at Stony Brook. $3 1019194
773 0 $t Dissertation Abstracts International $g 69-10B.
790 $a 0771
791 $a Ph.D.
792 $a 2007
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3334909