東華大學圖書館 |

Language: English

Help

回圖書館首頁

手機版館藏查詢

Back

Switch To: Labeled | MARC Mode | ISBD

Molecular mechanisms for angiotensin...

Meier, Renate K.

Linked to FindBook

Google Book

Amazon

博客來

Molecular mechanisms for angiotensin II-dependent transcriptional activation of the human steroidogenic acute regulatory (StAR) protein gene.

Record Type:	Language materials, printed : Monograph/item
Title/Author:	Molecular mechanisms for angiotensin II-dependent transcriptional activation of the human steroidogenic acute regulatory (StAR) protein gene./
Author:	Meier, Renate K.
Description:	78 p.
Notes:	Source: Masters Abstracts International, Volume: 47-06, page: 3422.
Contained By:	Masters Abstracts International47-06.
Subject:	Biology, Molecular. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=1468584
ISBN:	9781109300451

Molecular mechanisms for angiotensin II-dependent transcriptional activation of the human steroidogenic acute regulatory (StAR) protein gene.
Meier, Renate K.

Molecular mechanisms for angiotensin II-dependent transcriptional activation of the human steroidogenic acute regulatory (StAR) protein gene. - 78 p.

Source: Masters Abstracts International, Volume: 47-06, page: 3422.

Thesis (M.S.)--University of Louisville, 2009.

Steroid hormone biosynthesis is dependent upon the synthesis of steroidogenic acute regulatory protein (StAR). Regulation of the adrenal hormone, aldosterone, is critical for regulating blood pressure, and the main regulator of aldosterone is angiotensin II (Ang II). Therefore, Ang II regulation of StAR is key to aldosterone production. I have identified the DNA elements and transcription factors important for Ang II activation of the human StAR gene. I provide the first molecular characterization for hStAR activation by showing that SF-1, YY1, and CREMalpha/gamma are recruited to the proximal StAR promoter after Ang II treatment. Further, I show that COUP-TF I increases the basal activity of the StAR promoter and binds simultaneously with GST-SF-1 to the functional SF-1 site in the StAR proximal promoter. I propose that COUP-TF I regulates basal StAR transcription and that YY1, SF-1 and CREM alpha/gamma regulate the Ang II response.

ISBN: 9781109300451Subjects--Topical Terms:

1017719
Biology, Molecular.

Molecular mechanisms for angiotensin II-dependent transcriptional activation of the human steroidogenic acute regulatory (StAR) protein gene.
LDR:01791nam 2200253 4500 001 1398093
005 20110907152330.5
008 130515s2009 ||||||||||||||||| ||eng d
020 $a 9781109300451
035 $a (UMI)AAI1468584
035 $a AAI1468584
040 $a UMI $c UMI
100 1 $a Meier, Renate K. $3 1676965
245 1 0 $a Molecular mechanisms for angiotensin II-dependent transcriptional activation of the human steroidogenic acute regulatory (StAR) protein gene.
300 $a 78 p.
500 $a Source: Masters Abstracts International, Volume: 47-06, page: 3422.
502 $a Thesis (M.S.)--University of Louisville, 2009.
520 $a Steroid hormone biosynthesis is dependent upon the synthesis of steroidogenic acute regulatory protein (StAR). Regulation of the adrenal hormone, aldosterone, is critical for regulating blood pressure, and the main regulator of aldosterone is angiotensin II (Ang II). Therefore, Ang II regulation of StAR is key to aldosterone production. I have identified the DNA elements and transcription factors important for Ang II activation of the human StAR gene. I provide the first molecular characterization for hStAR activation by showing that SF-1, YY1, and CREMalpha/gamma are recruited to the proximal StAR promoter after Ang II treatment. Further, I show that COUP-TF I increases the basal activity of the StAR promoter and binds simultaneously with GST-SF-1 to the functional SF-1 site in the StAR proximal promoter. I propose that COUP-TF I regulates basal StAR transcription and that YY1, SF-1 and CREM alpha/gamma regulate the Ang II response.
590 $a School code: 0110.
650 4 $a Biology, Molecular. $3 1017719
650 4 $a Agriculture, Forestry and Wildlife. $3 783690
690 $a 0307
690 $a 0478
710 2 $a University of Louisville. $3 1017614
773 0 $t Masters Abstracts International $g 47-06.
790 $a 0110
791 $a M.S.
792 $a 2009
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=1468584