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Stromal changes and transforming gro...

De Vries, Lindsey.

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Stromal changes and transforming growth factor-beta1 in the mammary gland during the dry period of dairy cows.

Record Type:	Language materials, printed : Monograph/item
Title/Author:	Stromal changes and transforming growth factor-beta1 in the mammary gland during the dry period of dairy cows./
Author:	De Vries, Lindsey.
Description:	85 p.
Notes:	Source: Masters Abstracts International, Volume: 47-06, page: 3337.
Contained By:	Masters Abstracts International47-06.
Subject:	Agriculture, Animal Culture and Nutrition. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=1468323
ISBN:	9781109242836

Stromal changes and transforming growth factor-beta1 in the mammary gland during the dry period of dairy cows.
De Vries, Lindsey.

Stromal changes and transforming growth factor-beta1 in the mammary gland during the dry period of dairy cows. - 85 p.

Source: Masters Abstracts International, Volume: 47-06, page: 3337.

Thesis (M.S.)--Michigan State University, 2009.

Our first objective was to determine if mammary remodeling during the dry period of dairy cows is characterized by a transient increase in stromal fibronectin, myofibroblasts, stromelysin (MMP-3), transforming growth factor-beta1 (TGF-beta1) and its receptor, TGF-betaR2. The second objective was to determine if TGF-beta1 increases mammary stromal remodeling during the dry period. Mammary biopsies were obtained from nine cows at: late lactation, 1 week after dry-off, 3 weeks before expected calving, and 1 week before expected calving. For objective 2, tissue was incubated for 2 h with 0 or 5 ng TGF-beta1/ml. Intralobular stromal area was greater at 1 week dry and 3 weeks before calving than at 1 week before calving (P=0.02). The number of fibroblasts was greater at one week dry than 1 week before calving (P=0.02). Stromal TGF-beta1 was 15% lower during the dry period than in late lactation (P=0.02). The number of myofibroblasts and the expression of fibronectin, MMP-3, or TGF-betaR2 did not differ. Incubation with TGF-beta1 had no effect on the percent intralobular stroma area expression of fibronectin or MMP-3. The number of myofibroblasts increased by 19% in the intralobular stroma (P=0.03) and the percent of myofibroblasts tended to increase by 4% (P=0.06) in tissue incubated with TGF-beta1. Based on these findings, TGF-beta1 may be important in the activation of stromal cells during involution and mammogenesis of the bovine mammary gland.

ISBN: 9781109242836Subjects--Topical Terms:

1017857
Agriculture, Animal Culture and Nutrition.

Stromal changes and transforming growth factor-beta1 in the mammary gland during the dry period of dairy cows.
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020 $a 9781109242836
035 $a (UMI)AAI1468323
035 $a AAI1468323
040 $a UMI $c UMI
100 1 $a De Vries, Lindsey. $3 1676957
245 1 0 $a Stromal changes and transforming growth factor-beta1 in the mammary gland during the dry period of dairy cows.
300 $a 85 p.
500 $a Source: Masters Abstracts International, Volume: 47-06, page: 3337.
500 $a Adviser: Michael J. VandeHaar.
502 $a Thesis (M.S.)--Michigan State University, 2009.
520 $a Our first objective was to determine if mammary remodeling during the dry period of dairy cows is characterized by a transient increase in stromal fibronectin, myofibroblasts, stromelysin (MMP-3), transforming growth factor-beta1 (TGF-beta1) and its receptor, TGF-betaR2. The second objective was to determine if TGF-beta1 increases mammary stromal remodeling during the dry period. Mammary biopsies were obtained from nine cows at: late lactation, 1 week after dry-off, 3 weeks before expected calving, and 1 week before expected calving. For objective 2, tissue was incubated for 2 h with 0 or 5 ng TGF-beta1/ml. Intralobular stromal area was greater at 1 week dry and 3 weeks before calving than at 1 week before calving (P=0.02). The number of fibroblasts was greater at one week dry than 1 week before calving (P=0.02). Stromal TGF-beta1 was 15% lower during the dry period than in late lactation (P=0.02). The number of myofibroblasts and the expression of fibronectin, MMP-3, or TGF-betaR2 did not differ. Incubation with TGF-beta1 had no effect on the percent intralobular stroma area expression of fibronectin or MMP-3. The number of myofibroblasts increased by 19% in the intralobular stroma (P=0.03) and the percent of myofibroblasts tended to increase by 4% (P=0.06) in tissue incubated with TGF-beta1. Based on these findings, TGF-beta1 may be important in the activation of stromal cells during involution and mammogenesis of the bovine mammary gland.
590 $a School code: 0128.
650 4 $a Agriculture, Animal Culture and Nutrition. $3 1017857
690 $a 0475
710 2 $a Michigan State University. $3 676168
773 0 $t Masters Abstracts International $g 47-06.
790 1 0 $a VandeHaar, Michael J., $e advisor
790 $a 0128
791 $a M.S.
792 $a 2009
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=1468323