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Regulation of CYP17A1 activity and i...

Billen, Machteld Joanna.

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Regulation of CYP17A1 activity and its potential implications on the development of boar taint.

Record Type:	Language materials, printed : Monograph/item
Title/Author:	Regulation of CYP17A1 activity and its potential implications on the development of boar taint./
Author:	Billen, Machteld Joanna.
Description:	86 p.
Notes:	Source: Masters Abstracts International, Volume: 47-05, page: 2703.
Contained By:	Masters Abstracts International47-05.
Subject:	Biology, Animal Physiology. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=MR47751
ISBN:	9780494477519

Regulation of CYP17A1 activity and its potential implications on the development of boar taint.
Billen, Machteld Joanna.

Regulation of CYP17A1 activity and its potential implications on the development of boar taint. - 86 p.

Source: Masters Abstracts International, Volume: 47-05, page: 2703.

Thesis (M.Sc.)--University of Guelph (Canada), 2009.

Testicular 16-androstene steroids, in particular 5alpha-androstenone, contribute to an off-odour and off-flavour known as boar taint. Cytochrome P450 C17 (CYP17A1) catalyses the key regulatory step in the formation of the 16-androstene steroids from pregnenolone via the andien-beta synthase reaction, or the synthesis of the glucocorticoid and sex steroids via 17alpha-hydroxylase and C17,20 lyase pathways respectively. The goals of this research were to investigate the effect of both isoforms of CYB5 and the phosphorylation status of CYP17A1 on these different activities of CYP17A1, by overexpressing these proteins in HEK-293 cells. CYB5A increased andien-beta synthase and C17,20 lyase activities while CYB5B increased C17,20 lyase but had no effect on andien-beta synthase activity. Phosphorylation of CYP17A1 at Ser 106 in the presence of CYB5A increased C17,20 lyase and andien-beta synthase activity. This suggests that decreased expression of CYB5A and increased expression of CYB5B would maintain sex steroid production and decrease boar taint.

ISBN: 9780494477519Subjects--Topical Terms:

1017835
Biology, Animal Physiology.

Regulation of CYP17A1 activity and its potential implications on the development of boar taint.
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020 $a 9780494477519
035 $a (UMI)AAIMR47751
035 $a AAIMR47751
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100 1 $a Billen, Machteld Joanna. $3 1676921
245 1 0 $a Regulation of CYP17A1 activity and its potential implications on the development of boar taint.
300 $a 86 p.
500 $a Source: Masters Abstracts International, Volume: 47-05, page: 2703.
502 $a Thesis (M.Sc.)--University of Guelph (Canada), 2009.
520 $a Testicular 16-androstene steroids, in particular 5alpha-androstenone, contribute to an off-odour and off-flavour known as boar taint. Cytochrome P450 C17 (CYP17A1) catalyses the key regulatory step in the formation of the 16-androstene steroids from pregnenolone via the andien-beta synthase reaction, or the synthesis of the glucocorticoid and sex steroids via 17alpha-hydroxylase and C17,20 lyase pathways respectively. The goals of this research were to investigate the effect of both isoforms of CYB5 and the phosphorylation status of CYP17A1 on these different activities of CYP17A1, by overexpressing these proteins in HEK-293 cells. CYB5A increased andien-beta synthase and C17,20 lyase activities while CYB5B increased C17,20 lyase but had no effect on andien-beta synthase activity. Phosphorylation of CYP17A1 at Ser 106 in the presence of CYB5A increased C17,20 lyase and andien-beta synthase activity. This suggests that decreased expression of CYB5A and increased expression of CYB5B would maintain sex steroid production and decrease boar taint.
520 $a Key Words: CYP17A1, CYB5, Androstenone, C17, 20 lyase, 17alpha-hydroxylase
590 $a School code: 0081.
650 4 $a Biology, Animal Physiology. $3 1017835
650 4 $a Biology, Zoology. $3 1018632
650 4 $a Agriculture, Animal Culture and Nutrition. $3 1017857
690 $a 0433
690 $a 0472
690 $a 0475
710 2 $a University of Guelph (Canada). $3 1018650
773 0 $t Masters Abstracts International $g 47-05.
790 $a 0081
791 $a M.Sc.
792 $a 2009
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=MR47751