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Characterization and prevention of F...

Channarayapatna Krishnegowda, Girish.

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Characterization and prevention of Fusarium mycotoxicoses in turkeys.

Record Type:	Language materials, printed : Monograph/item
Title/Author:	Characterization and prevention of Fusarium mycotoxicoses in turkeys./
Author:	Channarayapatna Krishnegowda, Girish.
Description:	183 p.
Notes:	Source: Dissertation Abstracts International, Volume: 71-01, Section: B, page: 0003.
Contained By:	Dissertation Abstracts International71-01B.
Subject:	Health Sciences, Toxicology. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=NR55943
ISBN:	9780494559437

Characterization and prevention of Fusarium mycotoxicoses in turkeys.
Channarayapatna Krishnegowda, Girish.

Characterization and prevention of Fusarium mycotoxicoses in turkeys. - 183 p.

Source: Dissertation Abstracts International, Volume: 71-01, Section: B, page: 0003.

Thesis (Ph.D.)--University of Guelph (Canada), 2009.

Mycotoxins are secondary fungal metabolites with varying chemical structures and biological effects. Contamination of foods and feeds with mycotoxins is a significant problem worldwide. The major mycotoxin producing fungi are Aspergillus, Penicillium and Fusarium. Occurrence of Fusarium mycotoxins is common in temperate regions of the world including Canada. There is a lack of information on the effects of feeding low concentrations of feed-borne Fusarium mycotoxins on turkeys. Experiments were conducted to study the effects of feeding grains naturally contaminated with low concentrations of Fusarium mycotoxins to turkeys. The efficacy of a polymeric glucomannan mycotoxin adsorbent (GMA) in preventing any adverse effects was also evaluated. The contaminated diets were formulated by replacing control corn and wheat with contaminated corn and wheat, respectively. The feeding of contaminated grains adversely affected performance, metabolism and health of turkeys. Supplementation of contaminated diets with GMA prevented many of the adverse effects. The reduced performance was thought be due to decreased absorption of nutrients from the gut and due to behavioral changes caused by alterations in brain neurotransmission. This hypothesis was tested by measuring the effect of diet on intestinal morphology and brain neurochemistry. The feeding of contaminated grains adversely affected intestinal morphology and brain serotonergic neurotransmission. Supplementation of GMA prevented many of these adverse effects. The effects of feeding contaminated diets on intestinal immunity and cell proliferation, and histology of immune organs revealed adverse effects on intestinal lymphocyte subsets, cell proliferation in crypts and cellularity of lymphoid organs. GMA prevented the adverse effects on intestinal lymphocyte subsets. In summary, performance, metabolism, intestinal morphology and brain neurochemistry in turkeys was adversely affected by feed-borne Fusarium mycotoxins. The immune system of turkeys was sensitive to the effects of feed-borne Fusarium mycotoxins as reflected in adverse effects at both the systemic and at the intestinal levels. It was concluded that the feeding of grains naturally contaminated with Fusarium mycotoxins to turkeys should be minimised.

ISBN: 9780494559437Subjects--Topical Terms:

1017752
Health Sciences, Toxicology.

Characterization and prevention of Fusarium mycotoxicoses in turkeys.
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100 1 $a Channarayapatna Krishnegowda, Girish. $3 1676815
245 1 0 $a Characterization and prevention of Fusarium mycotoxicoses in turkeys.
300 $a 183 p.
500 $a Source: Dissertation Abstracts International, Volume: 71-01, Section: B, page: 0003.
502 $a Thesis (Ph.D.)--University of Guelph (Canada), 2009.
520 $a Mycotoxins are secondary fungal metabolites with varying chemical structures and biological effects. Contamination of foods and feeds with mycotoxins is a significant problem worldwide. The major mycotoxin producing fungi are Aspergillus, Penicillium and Fusarium. Occurrence of Fusarium mycotoxins is common in temperate regions of the world including Canada. There is a lack of information on the effects of feeding low concentrations of feed-borne Fusarium mycotoxins on turkeys. Experiments were conducted to study the effects of feeding grains naturally contaminated with low concentrations of Fusarium mycotoxins to turkeys. The efficacy of a polymeric glucomannan mycotoxin adsorbent (GMA) in preventing any adverse effects was also evaluated. The contaminated diets were formulated by replacing control corn and wheat with contaminated corn and wheat, respectively. The feeding of contaminated grains adversely affected performance, metabolism and health of turkeys. Supplementation of contaminated diets with GMA prevented many of the adverse effects. The reduced performance was thought be due to decreased absorption of nutrients from the gut and due to behavioral changes caused by alterations in brain neurotransmission. This hypothesis was tested by measuring the effect of diet on intestinal morphology and brain neurochemistry. The feeding of contaminated grains adversely affected intestinal morphology and brain serotonergic neurotransmission. Supplementation of GMA prevented many of these adverse effects. The effects of feeding contaminated diets on intestinal immunity and cell proliferation, and histology of immune organs revealed adverse effects on intestinal lymphocyte subsets, cell proliferation in crypts and cellularity of lymphoid organs. GMA prevented the adverse effects on intestinal lymphocyte subsets. In summary, performance, metabolism, intestinal morphology and brain neurochemistry in turkeys was adversely affected by feed-borne Fusarium mycotoxins. The immune system of turkeys was sensitive to the effects of feed-borne Fusarium mycotoxins as reflected in adverse effects at both the systemic and at the intestinal levels. It was concluded that the feeding of grains naturally contaminated with Fusarium mycotoxins to turkeys should be minimised.
590 $a School code: 0081.
650 4 $a Health Sciences, Toxicology. $3 1017752
650 4 $a Agriculture, Animal Culture and Nutrition. $3 1017857
650 4 $a Health Sciences, Alternative Medicine. $3 1669893
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792 $a 2009
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