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Kisspeptin, a novel hypothalamic reg...

Whitlock, Brian Keith.

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Kisspeptin, a novel hypothalamic regulator of the somatotropic and gonadotropic axes in ruminants.

Record Type:	Language materials, printed : Monograph/item
Title/Author:	Kisspeptin, a novel hypothalamic regulator of the somatotropic and gonadotropic axes in ruminants./
Author:	Whitlock, Brian Keith.
Description:	240 p.
Notes:	Source: Dissertation Abstracts International, Volume: 70-12, Section: B, page: 7295.
Contained By:	Dissertation Abstracts International70-12B.
Subject:	Biology, Neuroscience. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3386173
ISBN:	9781109521726

Kisspeptin, a novel hypothalamic regulator of the somatotropic and gonadotropic axes in ruminants.
Whitlock, Brian Keith.

Kisspeptin, a novel hypothalamic regulator of the somatotropic and gonadotropic axes in ruminants. - 240 p.

Source: Dissertation Abstracts International, Volume: 70-12, Section: B, page: 7295.

Thesis (Ph.D.)--Auburn University, 2009.

Reproductive inefficiency in dairy cows is a worldwide problem. Factors that improve reproductive performance even slightly could have large impacts on the efficiency of food animal production. The neuropeptide kisspeptin is vital to the regulation of the hypothalamic-pituitary gonadal axis and required for normal reproduction. Evidence suggests that kisspeptin may be an integrator of metabolism and reproduction.

ISBN: 9781109521726Subjects--Topical Terms:

1017680
Biology, Neuroscience.

Kisspeptin, a novel hypothalamic regulator of the somatotropic and gonadotropic axes in ruminants.
LDR:02982nam 2200325 4500 001 1397942
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008 130515s2009 ||||||||||||||||| ||eng d
020 $a 9781109521726
035 $a (UMI)AAI3386173
035 $a AAI3386173
040 $a UMI $c UMI
100 1 $a Whitlock, Brian Keith. $3 1676803
245 1 0 $a Kisspeptin, a novel hypothalamic regulator of the somatotropic and gonadotropic axes in ruminants.
300 $a 240 p.
500 $a Source: Dissertation Abstracts International, Volume: 70-12, Section: B, page: 7295.
500 $a Adviser: James L. Sartin.
502 $a Thesis (Ph.D.)--Auburn University, 2009.
520 $a Reproductive inefficiency in dairy cows is a worldwide problem. Factors that improve reproductive performance even slightly could have large impacts on the efficiency of food animal production. The neuropeptide kisspeptin is vital to the regulation of the hypothalamic-pituitary gonadal axis and required for normal reproduction. Evidence suggests that kisspeptin may be an integrator of metabolism and reproduction.
520 $a Growth hormone is an important regulator of metabolism and it is necessary for optimal reproduction. Kisspeptin has been shown to stimulate growth hormone release both in vitro and in vivo. However, the mechanism(s) underlying kisspeptin-stimulated growth hormone release have not been elucidated in large domestic species, specifically ruminants.
520 $a The effects of kisspeptin on luteinizing hormone release and growth hormone release in ruminants (cattle and sheep) during different physiologic conditions and following different routes are described here. A study also describes the effects of kisspeptin on ovulation in cattle. Peripheral administration of kisspeptin increases circulating luteinizing hormone in cattle and sheep. Kisspeptin stimulates circulating growth hormone concentrations in ovariectomized cows only after cows are pre-treated with exogenous gonadal steroids. The stage of lactation and possibly degree of negative energy balance enhances sensitivity of the gonadotropic axis but not the somatotropic axis to kisspeptin. Central but not peripheral treatment of ovariectomized sheep with kisspeptin increases growth hormone release suggesting a central effect. Lastly, data presented here support the notion that kisspeptin may be a useful ovulation-inducing agent in cattle.
520 $a These results provide the first evidence that kisspeptin may be an integrator of the somatotropic and gonadotropic axes in ruminants. As a result, the potential to improve reproductive function in domestic species through manipulation of the somatotropic and gonadotropic axes may be realized.
590 $a School code: 0012.
650 4 $a Biology, Neuroscience. $3 1017680
650 4 $a Biology, Animal Physiology. $3 1017835
650 4 $a Agriculture, Animal Culture and Nutrition. $3 1017857
690 $a 0317
690 $a 0433
690 $a 0475
710 2 $a Auburn University. $3 1020457
773 0 $t Dissertation Abstracts International $g 70-12B.
790 1 0 $a Sartin, James L., $e advisor
790 $a 0012
791 $a Ph.D.
792 $a 2009
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3386173