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Skeletal muscle impairments in peopl...

Tuttle, Lori Jeanne.

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Skeletal muscle impairments in people with diabetes and peripheral neuropathy.

Record Type:	Language materials, printed : Monograph/item
Title/Author:	Skeletal muscle impairments in people with diabetes and peripheral neuropathy./
Author:	Tuttle, Lori Jeanne.
Description:	146 p.
Notes:	Source: Dissertation Abstracts International, Volume: 72-06, Section: B, page: .
Contained By:	Dissertation Abstracts International72-06B.
Subject:	Health Sciences, Rehabilitation and Therapy. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3449855
ISBN:	9781124575704

Skeletal muscle impairments in people with diabetes and peripheral neuropathy.
Tuttle, Lori Jeanne.

Skeletal muscle impairments in people with diabetes and peripheral neuropathy. - 146 p.

Source: Dissertation Abstracts International, Volume: 72-06, Section: B, page: .

Thesis (Ph.D.)--Washington University in St. Louis, 2011.

Diabetes mellitus (DM) is a chronic disease that affects almost 24 million people and has large socioeconomic costs. Of these 24 million people, 60-70% will develop some form of nervous system impairment, including peripheral neuropathy (PN). It is important to understand muscle structure and impairments in people with DM+PN in order to determine appropriate interventions to limit the disability that is associated with DM+PN. The objectives of this research are to describe skeletal muscle structure in people with DM+PN, to determine whether neuropathic muscle structure and composition are associated with movement impairments and functional limitations, and whether neuropathic muscle can be modulated by activity level and/or an exercise intervention.

ISBN: 9781124575704Subjects--Topical Terms:

1017926
Health Sciences, Rehabilitation and Therapy.

Skeletal muscle impairments in people with diabetes and peripheral neuropathy.
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020 $a 9781124575704
035 $a (UMI)AAI3449855
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100 1 $a Tuttle, Lori Jeanne. $3 1675679
245 1 0 $a Skeletal muscle impairments in people with diabetes and peripheral neuropathy.
300 $a 146 p.
500 $a Source: Dissertation Abstracts International, Volume: 72-06, Section: B, page: .
500 $a Adviser: Michael Mueller.
502 $a Thesis (Ph.D.)--Washington University in St. Louis, 2011.
520 $a Diabetes mellitus (DM) is a chronic disease that affects almost 24 million people and has large socioeconomic costs. Of these 24 million people, 60-70% will develop some form of nervous system impairment, including peripheral neuropathy (PN). It is important to understand muscle structure and impairments in people with DM+PN in order to determine appropriate interventions to limit the disability that is associated with DM+PN. The objectives of this research are to describe skeletal muscle structure in people with DM+PN, to determine whether neuropathic muscle structure and composition are associated with movement impairments and functional limitations, and whether neuropathic muscle can be modulated by activity level and/or an exercise intervention.
520 $a In Chapter 2, we examine whether intermuscular adipose tissue (IMAT) volumes are different between groups with DM, DM+PN, and a group without DM or PN (NoDMPN). We report that there is no difference in IMAT volumes in these groups, but that increased IMAT is associated with poorer physical performance and the DM+PN group had the lowest measures of physical performance. In Chapter 3, we examine whether activity level in people with DM+PN is associated with IMAT. We report that activity level is inversely associated with IMAT volumes. In Chapter 4, we examine whether an exercise intervention for people with DM+PN is able to improve function and change IMAT and muscle volumes. We report that our duration-based exercise program was successful in increasing 6 minute walk distance, but there was no change in IMAT or muscle volumes. In Chapter 5, we provide a case report detailing an exercise intervention for a specific individual with DM+PN who was able to increase his average activity level and shows improvement in muscle performance and physical function.
520 $a Overall, our results suggest that people with DM+PN have lower levels of physical performance than their peers and increased IMAT is associated with poor physical performance. Increased activity levels are associated with decreased IMAT volume. People with DM+PN are able to safely increase their walking distance following an exercise intervention, but we did not see a change in muscle composition. Additional research is needed to determine the specific roles of IMAT in skeletal muscle and function.
590 $a School code: 0252.
650 4 $a Health Sciences, Rehabilitation and Therapy. $3 1017926
650 4 $a Health Sciences, Medicine and Surgery. $3 1017756
650 4 $a Health Sciences, Public Health. $3 1017659
690 $a 0382
690 $a 0564
690 $a 0573
710 2 $a Washington University in St. Louis. $b Movement Science. $3 1675680
773 0 $t Dissertation Abstracts International $g 72-06B.
790 1 0 $a Mueller, Michael, $e advisor
790 1 0 $a Cade, W. Todd $e committee member
790 1 0 $a Earhart, Gammon $e committee member
790 1 0 $a Sinacore, David $e committee member
790 1 0 $a Stark, Susan $e committee member
790 1 0 $a Strube, Michael $e committee member
790 $a 0252
791 $a Ph.D.
792 $a 2011
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3449855