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A pathway analysis candidate gene ap...

Thomson, Lindsay Annette.

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A pathway analysis candidate gene approach to seasonal reproductive timing in mammals with a focus on Period and casein kinase 1 in Peromyscus.

Record Type:	Language materials, printed : Monograph/item
Title/Author:	A pathway analysis candidate gene approach to seasonal reproductive timing in mammals with a focus on Period and casein kinase 1 in Peromyscus./
Author:	Thomson, Lindsay Annette.
Description:	87 p.
Notes:	Source: Masters Abstracts International, Volume: 49-02, page: .
Contained By:	Masters Abstracts International49-02.
Subject:	Biology, Molecular. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=MR68222
ISBN:	9780494682227

A pathway analysis candidate gene approach to seasonal reproductive timing in mammals with a focus on Period and casein kinase 1 in Peromyscus.
Thomson, Lindsay Annette.

A pathway analysis candidate gene approach to seasonal reproductive timing in mammals with a focus on Period and casein kinase 1 in Peromyscus. - 87 p.

Source: Masters Abstracts International, Volume: 49-02, page: .

Thesis (M.Sc.)--Trent University (Canada), 2010.

This thesis chronicles three methods to apply molecular and gene function knowledge derived from model species to non-model species of ecological interest for the complex trait of seasonal reproductive timing. 1) Selective amplification of specific gene regions with reported polymorphisms and/or genotype-phenotype relationships from model organisms in polar bear (Ursus maritimus ), flying squirrel (Glaucomys sabrinus and volans) and caribou (Rangifer tarandus) yielded 1 synonymous polymorphism in 40 fragments. 2) Amplification of Per1 Ex2 in various species was performed to compare distance estimates between seasonally constrained and unconstrained breeding mammals with the result supporting no significant difference between the groups. 3) mRNA sequencing of Peromyscus leucopus and maniculatus from varying latitudes at Per1, Per2, CK1epsilon and CK1delta was performed with regions of interest being analyzed at a larger scale. 112 polymorphic sites were found with three sites suggesting a latitudinal cline in both species. Additionally, a polymorphic polyglyciene repeat motif was discovered near the C-terminal end of Per1.

ISBN: 9780494682227Subjects--Topical Terms:

1017719
Biology, Molecular.

A pathway analysis candidate gene approach to seasonal reproductive timing in mammals with a focus on Period and casein kinase 1 in Peromyscus.
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020 $a 9780494682227
035 $a (UMI)AAIMR68222
035 $a AAIMR68222
040 $a UMI $c UMI
100 1 $a Thomson, Lindsay Annette. $3 1673337
245 1 2 $a A pathway analysis candidate gene approach to seasonal reproductive timing in mammals with a focus on Period and casein kinase 1 in Peromyscus.
300 $a 87 p.
500 $a Source: Masters Abstracts International, Volume: 49-02, page: .
502 $a Thesis (M.Sc.)--Trent University (Canada), 2010.
520 $a This thesis chronicles three methods to apply molecular and gene function knowledge derived from model species to non-model species of ecological interest for the complex trait of seasonal reproductive timing. 1) Selective amplification of specific gene regions with reported polymorphisms and/or genotype-phenotype relationships from model organisms in polar bear (Ursus maritimus ), flying squirrel (Glaucomys sabrinus and volans) and caribou (Rangifer tarandus) yielded 1 synonymous polymorphism in 40 fragments. 2) Amplification of Per1 Ex2 in various species was performed to compare distance estimates between seasonally constrained and unconstrained breeding mammals with the result supporting no significant difference between the groups. 3) mRNA sequencing of Peromyscus leucopus and maniculatus from varying latitudes at Per1, Per2, CK1epsilon and CK1delta was performed with regions of interest being analyzed at a larger scale. 112 polymorphic sites were found with three sites suggesting a latitudinal cline in both species. Additionally, a polymorphic polyglyciene repeat motif was discovered near the C-terminal end of Per1.
520 $a Keywords: Candidate genes, seasonal reproductive timing, photoperiod, clock genes, Period, casein kinase 1
590 $a School code: 0513.
650 4 $a Biology, Molecular. $3 1017719
650 4 $a Biology, Genetics. $3 1017730
650 4 $a Biology, Cell. $3 1017686
690 $a 0307
690 $a 0369
690 $a 0379
710 2 $a Trent University (Canada). $3 1028970
773 0 $t Masters Abstracts International $g 49-02.
790 $a 0513
791 $a M.Sc.
792 $a 2010
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=MR68222