東華大學圖書館 |

Language: English

Help

回圖書館首頁

手機版館藏查詢

Back

Switch To: Labeled | MARC Mode | ISBD

Selective genotyping using Genome Wi...

Goher, Mohamed.

Linked to FindBook

Google Book

Amazon

博客來

Selective genotyping using Genome Wide Association Studies for mapping loci associated to fiber diameter in Merino sheep.

Record Type:	Language materials, printed : Monograph/item
Title/Author:	Selective genotyping using Genome Wide Association Studies for mapping loci associated to fiber diameter in Merino sheep./
Author:	Goher, Mohamed.
Description:	65 p.
Notes:	Source: Masters Abstracts International, Volume: 48-06, page: 3464.
Contained By:	Masters Abstracts International48-06.
Subject:	Biology, Molecular. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=1476792
ISBN:	9781124019673

Selective genotyping using Genome Wide Association Studies for mapping loci associated to fiber diameter in Merino sheep.
Goher, Mohamed.

Selective genotyping using Genome Wide Association Studies for mapping loci associated to fiber diameter in Merino sheep. - 65 p.

Source: Masters Abstracts International, Volume: 48-06, page: 3464.

Thesis (M.S.)--University of Nevada, Reno, 2010.

The objective of this study was to investigate methods and statistical power for mapping quantitative trait loci (QTL) using selective genotyping and Illumina's 50K BeadChip. A large unrelated population is recorded for a phenotypic trait. Animals with extreme phenotypes are used for genotyping with Illumina's arrays and QTL are mapped by linkage disequilibrium (LD). We carried out computer simulations to compute statistical power using this approach after varying QTL allele frequency, proportion selected in the extremes, and population size. For example, power for a population of 1,000 animals after genotyping the top and bottom 5% (QTL effect of 0.5 phenotypic standard deviations, alpha of 0.01 and allele frequency of 0.1) and assuming maximum LD, was 0.95. The method was tested in a Merino flock with 979 ewes in which fiber diameter (FD) was recorded. Illumina's 50K Bead Chip was used for simultaneous genotyping of 54,241 SNPs in selected animals (24 in each extreme) but only within a year class and breed. A total of 208 tests were significant out of 18,214 SNPs tested at significance level of 0.01. There were more significant tests than expected by chance. The highest significant results were obtained in Chromosomes 1, 14, 15, 21 and 26. Validation of the results must be confirmed in the unselected population.

ISBN: 9781124019673Subjects--Topical Terms:

1017719
Biology, Molecular.

Selective genotyping using Genome Wide Association Studies for mapping loci associated to fiber diameter in Merino sheep.
LDR:02365nam 2200313 4500 001 1393262
005 20110311132646.5
008 130515s2010 ||||||||||||||||| ||eng d
020 $a 9781124019673
035 $a (UMI)AAI1476792
035 $a AAI1476792
040 $a UMI $c UMI
100 1 $a Goher, Mohamed. $3 1671780
245 1 0 $a Selective genotyping using Genome Wide Association Studies for mapping loci associated to fiber diameter in Merino sheep.
300 $a 65 p.
500 $a Source: Masters Abstracts International, Volume: 48-06, page: 3464.
500 $a Adviser: Luis Gomez-Raya.
502 $a Thesis (M.S.)--University of Nevada, Reno, 2010.
520 $a The objective of this study was to investigate methods and statistical power for mapping quantitative trait loci (QTL) using selective genotyping and Illumina's 50K BeadChip. A large unrelated population is recorded for a phenotypic trait. Animals with extreme phenotypes are used for genotyping with Illumina's arrays and QTL are mapped by linkage disequilibrium (LD). We carried out computer simulations to compute statistical power using this approach after varying QTL allele frequency, proportion selected in the extremes, and population size. For example, power for a population of 1,000 animals after genotyping the top and bottom 5% (QTL effect of 0.5 phenotypic standard deviations, alpha of 0.01 and allele frequency of 0.1) and assuming maximum LD, was 0.95. The method was tested in a Merino flock with 979 ewes in which fiber diameter (FD) was recorded. Illumina's 50K Bead Chip was used for simultaneous genotyping of 54,241 SNPs in selected animals (24 in each extreme) but only within a year class and breed. A total of 208 tests were significant out of 18,214 SNPs tested at significance level of 0.01. There were more significant tests than expected by chance. The highest significant results were obtained in Chromosomes 1, 14, 15, 21 and 26. Validation of the results must be confirmed in the unselected population.
590 $a School code: 0139.
650 4 $a Biology, Molecular. $3 1017719
650 4 $a Agriculture, Animal Culture and Nutrition. $3 1017857
650 4 $a Biology, Bioinformatics. $3 1018415
690 $a 0307
690 $a 0475
690 $a 0715
710 2 $a University of Nevada, Reno. $b Animal Science. $3 1671781
773 0 $t Masters Abstracts International $g 48-06.
790 1 0 $a Gomez-Raya, Luis, $e advisor
790 1 0 $a Rauw, Wendy M. $e committee member
790 1 0 $a Forister, Matt $e committee member
790 $a 0139
791 $a M.S.
792 $a 2010
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=1476792