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Immunomodulatory properties of Noni ...

Lohani, Madhukar.

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Immunomodulatory properties of Noni (Morinda citrifolia ).

Record Type:	Language materials, printed : Monograph/item
Title/Author:	Immunomodulatory properties of Noni (Morinda citrifolia )./
Author:	Lohani, Madhukar.
Description:	76 p.
Notes:	Source: Masters Abstracts International, Volume: 48-05, page: 2945.
Contained By:	Masters Abstracts International48-05.
Subject:	Agriculture, Animal Culture and Nutrition. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=1475534
ISBN:	9781109746976

Immunomodulatory properties of Noni (Morinda citrifolia ).
Lohani, Madhukar.

Immunomodulatory properties of Noni (Morinda citrifolia ). - 76 p.

Source: Masters Abstracts International, Volume: 48-05, page: 2945.

Thesis (M.S.)--Clemson University, 2010.

Noni (Morinda citrifolia) is a popular medicinal plant of family Rubiaceae. Its fruit is rich in various phytochemicals and polysaccharides. Anecdotal evidence indicates that it was used to stimulate the immune system and, thus, to fight various infections. Limited in vitro studies also support the immunomodulatory role of Noni, however only one study utilized an animal model. The purpose of this study was to examine the immunomodulatory properties of Noni fruit the broiler chicken.

ISBN: 9781109746976Subjects--Topical Terms:

1017857
Agriculture, Animal Culture and Nutrition.

Immunomodulatory properties of Noni (Morinda citrifolia ).
LDR:02593nam 2200337 4500 001 1393238
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020 $a 9781109746976
035 $a (UMI)AAI1475534
035 $a AAI1475534
040 $a UMI $c UMI
100 1 $a Lohani, Madhukar. $3 1671747
245 1 0 $a Immunomodulatory properties of Noni (Morinda citrifolia ).
300 $a 76 p.
500 $a Source: Masters Abstracts International, Volume: 48-05, page: 2945.
500 $a Adviser: Denzil V. Maurice.
502 $a Thesis (M.S.)--Clemson University, 2010.
520 $a Noni (Morinda citrifolia) is a popular medicinal plant of family Rubiaceae. Its fruit is rich in various phytochemicals and polysaccharides. Anecdotal evidence indicates that it was used to stimulate the immune system and, thus, to fight various infections. Limited in vitro studies also support the immunomodulatory role of Noni, however only one study utilized an animal model. The purpose of this study was to examine the immunomodulatory properties of Noni fruit the broiler chicken.
520 $a Different concentrations of dietary Noni were added to diets and fed to day-old broiler chickens for 3 to 6 weeks. Gut tissue and blood were sampled to determine the expression of selected genes, concentration of immunoglobulins and a1-acid glycoprotein. The results showed that Noni at 6% concentration increased the expression of Toll like receptor -4 (TLR-4) and TLR-5, chemokine (IL-8), interleukin-12 (IL-12), and decreased the expression of IL-6 and TLR-7. At 4% concentration, Noni stimulated the expression of TLR-3. Increased expression of TLR-3, TLR-4 and TLR-5 indicate antiviral and antibacterial properties of Noni fruits in chickens that are further strengthened by increased expression of IL-12 and IL-8. Decreased expression of IL-6 indicates anti-inflammatory properties of Noni. However, Noni did not have effects on serum and gut immunoglobulins or a1-acid glycoprotein concentration. Further investigations will be necessary to explore the active immunomodulatory ingredients of Noni and their effects on immunity during viral and bacterial infections.
590 $a School code: 0050.
650 4 $a Agriculture, Animal Culture and Nutrition. $3 1017857
650 4 $a Health Sciences, Alternative Medicine. $3 1669893
650 4 $a Health Sciences, Immunology. $3 1017716
690 $a 0475
690 $a 0496
690 $a 0982
710 2 $a Clemson University. $b Animal and Veterinary Sciences. $3 1671748
773 0 $t Masters Abstracts International $g 48-05.
790 1 0 $a Maurice, Denzil V., $e advisor
790 1 0 $a Moore, Brandon D. $e committee member
790 1 0 $a Toler, Joe E. $e committee member
790 1 0 $a Scott, Thomas R. $e committee member
790 $a 0050
791 $a M.S.
792 $a 2010
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=1475534